Navigation Links
Trio of biomarkers may help identify kidney cancer in early stages
Date:3/10/2013

PHILADELPHIA A new immunoassay that tests for the presence of three biomarkers appears to be a valid screening method for the early detection of malignant kidney cancer, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Renal cell carcinoma, a malignant tumor arising from the kidney, is one of the most difficult forms of cancer to detect and treat properly because it remains silent until disseminating to other organs," said Nam Hoon Cho, M.D., of the Department of Pathology at Yonsei University Health System in Seoul, Korea. "Furthermore, because imaging, which is high-cost, is seldom performed without any specific reasons, developing a blood-tumor biomarker is a great chance to detect the silent killer."

The new immunoassay developed by Cho and colleagues from Genomine Inc. measured the levels of three potential biomarkers for kidney cancer: nicotinamide N-methyltransferase (NNMT), L-plastin (LCP1) and nonmetastatic cells 1 protein (NM23A).

Using this assay, the researchers measured concentrations of NNMT, LCP1 and NM23A in 189 plasma samples from 102 healthy controls and patients with benign tumors and 87 patients with kidney cancer. Plasma levels indicated that all three biomarkers were highly elevated in patients with kidney cancer. For example, the median level of NNMT concentration in healthy controls was 68 pg/mL compared with 420 pg/mL for patients with kidney cancer.

Next, the researchers tested the ability of the immunoassay to distinguish plasma samples from healthy controls and patients with kidney cancer using the same 189 plasma samples already tested. The results indicated that the three-marker assay was highly accurate. When it correctly identified 90 percent of the samples from healthy controls, it also correctly identified 94.4 percent of the samples from patients with kidney cancer.

To validate the accuracy of the test, the researchers blind tested an additional 100 plasma samples from 73 healthy controls and 27 patients with kidney cancer. In this analysis, 67 of the samples from the 73 healthy controls and all of the samples from patients with kidney cancer were classified correctly.

"If this biomarker is truly valid and accurate to detect renal cell carcinoma, a number of patients with renal cell carcinoma could potentially be saved through early diagnosis," Cho said.

Cho and colleagues hope that this biomarker will soon be commercially available. They are currently working toward approval by the U.S. Food and Drug Administration.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Biomarkers can reveal IBS
2. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
3. Novel biomarkers reveal evidence of radiation exposure
4. Using biomarkers to identify and treat schizophrenia
5. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
6. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
7. Tracking down smallest biomarkers
8. Metabolic biomarkers for preventive molecular medicine
9. Kentucky team inhibits Alzheimers biomarkers in animal model by targeting astrocytes
10. NIH launches collaborative effort to find biomarkers for Parkinsons
11. Mayo Clinic-led study identifies biomarkers for early risk assessment of acute kidney injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2017)... ... January 15, 2017 , ... Going above and beyond ... strives to better communities around the world by offering the Gensuite team and ... opportunity for team members to become involved in a cause that is bigger ...
(Date:1/15/2017)... ... 14, 2017 , ... Wondering where to go this Valentine's Day? Well, there ... for a romantic, lobster feast in the comfort of your own home. Lobster Gram ... dinners will be featured until February 15th, 2017. , Romantic Dinner one is ...
(Date:1/14/2017)... ... 2017 , ... AgileMinder develops innovative products and services that bring "Care, Joy ... on Apple as a fun, free emoji sticker pack for iMessage. Use the stickers ... color coded values on The Emoji Scale. , On Apple: "The Emoji Scale ...
(Date:1/13/2017)... , ... January 13, 2017 , ... KOAMTAC ®, ... will be showcasing the next generation companion scanner and data collector at the National ... KDC270 has been created as an answer to the market’s need for more compact ...
(Date:1/13/2017)... (PRWEB) , ... January 13, 2017 , ... "We wanted ... attractive to wear," said one of two inventors from Virginia Beach, Va. , They ... normally mundane braces. , The accessories allow braces to be customized to suit ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... DALLAS, Pa. , Jan. 13, 2017  Secretary ... crowd of students, professors, and community members at Misericordia ... the opioid epidemic in Pennsylvania . ... health crisis I,ve seen so far in my professional ... Pennsylvania has been hit hard by heroin ...
(Date:1/13/2017)... BOISE, Idaho , Jan. 12, 2017 /PRNewswire/ ... status by Accreditation Commission for Health Care (ACHC) ... the largest national food and drug chain with ... service for pharmacy patients. Accreditation by ... meeting national standards to facilitate a higher level ...
(Date:1/12/2017)... According to a new market research report ... (Nebulizer), Injectable (Device), Ocular (Liquid), Topical (Solid), Implantable (Active), Transmucosal (Oral)), ... by MarketsandMarkets, market is projected to reach USD 1,669.40 Billion by ... 7.2% during the forecast period. Continue ... ...
Breaking Medicine Technology: