Navigation Links
Trio of Gene Variants Discovered That May Raise Alzheimer's Risk
Date:9/6/2009

Study suggests they're implicated in clearance of amyloid plaque from brain

SUNDAY, Sept. 6 (HealthDay News) -- Two international teams of scientists have uncovered three gene variants that up the risk for Alzheimer's disease, the most common form of dementia among the elderly and the seventh-leading cause of death in the United States.

Teams led by Dr. Philippe Amouyel of the Institut Pasteur de Lille in France, and Julie Williams, a professor of psychological medicine at Cardiff University School of Medicine in Wales, zeroed in on defects in the CLU, CR1 and PICALM genes, and also found another 13 gene variants that are solid candidates for further investigation, according to findings that appear in the Sept. 6 online issue of Nature Genetics. Until now, only four gene variants had previously been definitively associated with Alzheimer's -- APP, PS1, PS2 and APOE.

"Although the role of these two new genes [CLU and CR1] . . . is not yet known in detail, previous studies suggest that they may be involved in the elimination of the major component of amyloid plaques," explained Amouyel, the leader of the team that studied the CLU and CR1 genes. "Genetic variants at CLU, CR1 and APOE may influence susceptibility to late-onset forms of the disease."

According to Amouyel, one group of researchers carried out a two-stage analysis of genetic samples from more than 20,000 subjects. In parallel, Williams ran a similar study, discovering the PICALM gene mutations and independently discovering the CLU gene variants.

Most of the DNA samples came from France and other European countries, but U.S. labs contributed to Williams' study as well, including the National Institute on Aging (NIA) Laboratory of Neurogenetics, the Mayo Clinic and the Washington University School of Medicine in St. Louis.

"This is the most important finding in the genetic [component] of Alzheimer's in more than 10 years," said study co-author Alison Goate, a professor of genetics in psychiatry at Washington University School of Medicine and a member of the Alzheimer's Association Medical & Scientific Advisory Council.

Experts estimate that as many as 5.3 million Americans are living with Alzheimer's disease, which progressively kills brain cells. Alzheimer's typically attacks people over the age of 65. Symptoms include a range of cognitive, psychiatric and physical problems that eventually lead to death.

The sheer global impact of the illness and the lack of a cure were the driving forces behind the current research.

According to Amouyel, "the identification of these three genes has been possible, thanks to two major elements: first, the possibility to compare thousands of patients through a major collaboration between scientists; and second, the capacity to analyze genetic markers distributed all over the entire genome with high-tech tools, such as DNA chips."

Relatively little is known about how the newly discovered genes may increase the risk of Alzheimer's. But researchers have noted increased levels of CLU in the brains and cerebrospinal fluids of Alzheimer's patients. PICALM may play a role in the health of nerve cell synapses and may affect beta-amyloid deposits in the brain.

Each of the new genes probably contributes about 8 percent to an individual's risk of developing Alzheimer's, Goate said. In addition to genetic factors, there are likely to be environmental and lifestyle variables that also contribute to the risk, she noted.

"Identifying gene variants like CLU and PICALM advances our understanding of the many genetic factors that may contribute to overall risk for this devastating neurological disorder," Marcelle Morrison-Bogorad, associate director of NIA's neuroscience and neuropsychology of aging program, said in a statement. "This knowledge may then lead to novel disease pathways that can be targeted to develop new treatments."

In another genetic discovery reported in the same journal, Dutch researchers say they have found two new gene variants linked to amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. The variants appear to play a role in the neural pathways that are involved in this deadly disease, which involves the steady loss of neurons that results in muscle atrophy, paralysis and, finally, death.

More information

The Alzheimer's Association has more on the disease.



SOURCE: Philippe Amouyel, M.D., Ph.D., Institut Pasteur de Lille, France; Alison Goate, professor, genetics in psychiatry, Washington University School of Medicine, and member, Medical & Scientific Advisory Council, Alzheimer's Association, Chicago; Sept. 6, 2009, Nature Genetics, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Variants of umami taste receptor contribute to our individualized flavor worlds
2. MCG participating in national study to identify genetic variants in schizophrenia
3. Genetic variants predict recurrence of bladder cancer, patient survival
4. Mayo Clinic-led researchers confirm gene variants associated with the most common adult leukemia
5. Study IDs Gene Variants Tied to Sudden Cardiac Death
6. Biologist finds plant polymerases IV and V are really variants of Polymerase II
7. Genetic Variants Tied to Obesity
8. Newly found gene variants account for kidney diseases among African-Americans
9. Genetic variants associated with vitamin B12
10. Gene variants linked to metabolic syndrome and HDL cholesterol levels
11. Gene Variants Linked to Lung Cancer Identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Trio of Gene Variants Discovered That May Raise Alzheimer's Risk 
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... leading physicians, Paul Yost, will begin serving as new board chair for Orange ... month. Yost will serve the remainder of soon-to-be former chair Mark Refowitz’s term, ...
(Date:3/28/2017)... San Francisco, CA (PRWEB) , ... March 28, 2017 , ... ... million people suffering from acne, access to quality care can be limited while the ... skincare company that offers customized prescription acne care for every customer online, today released ...
(Date:3/28/2017)... ... March 28, 2017 , ... The Executives, Staff & Clients ... to for the Toys for Tots Literacy Campaign at their Semi-Annual Graduation and Fundraiser ... $70 billion, the U.S. ranks at number 14 internationally in literacy. Statistically, a direct ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... be offered by the American Association of Integrative Medicine and available for application ... providers at the AutismOne 2017 Conference in Colorado Springs. , Ed Arranga, president ...
(Date:3/28/2017)... ... March 28, 2017 , ... The ... in Atlantic City March 13-16, was a busy spot this year. Liz Solovay ... discussed strategies for preventing outbreaks among camp communities during the upcoming 2017 camping ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... STRASBOURG, France and TEL AVIV, Israel ... opening a subsidiary in Israel . This new ... , will be mostly dedicated to research and development of novel ... Emosis Ltd will also, when relevant, locally support commercialization and sales ... ...
(Date:3/28/2017)...  CASI Pharmaceuticals, Inc. (Nasdaq: CASI), a biopharmaceutical ... other unmet medical needs, announced today two poster ... annual meeting.  The first poster to be presented ... ENMD-2076 in Combination with Anti-PD1 in Syngeneic Cancer ... presented on April 4 is entitled " Kinase ...
(Date:3/28/2017)... The global flow cytometry ... by 2025, according to a new study by Grand ... and cancer is expected to upsurge the demand for ... coming years. In addition, higher number of physicians is ... cell therapy, due to adverse effects caused by chemotherapy ...
Breaking Medicine Technology: