Navigation Links
Trimming the fat boosts blood recovery after marrow transplant
Date:6/10/2009

Seeking ways to improve blood recovery after chemotherapy or bone marrow transplant, researchers at Children's Hospital Boston have discovered that fat cells, which accumulate in bone marrow as people age, inhibit the marrow's ability to produce new blood cells. Their study, published online June 10 by the journal Nature, suggests that blocking this fatty infiltration could help enhance patients' recovery after transplant.

Patients who have had radiation or chemotherapy show fatty infiltration in their marrow, and it's known that the more fat cells, the less blood-forming activity the marrow engages in. What hasn't been clear is whether the fat cells actually influence blood formation, or simply fill in empty space in the marrow.

Working with mice, researchers led by George Q. Daley, MD, PhD, director of the Stem Cell Transplantation Program at Children's, and Olaia Naveiras, MD, PhD, of the Division of Pediatric Hematology/Oncology at Children's and the Dana-Farber Cancer Institute, looked at marrow from different parts of the skeleton, which vary in fat composition. They found that the relatively fat-rich tail bones had only 25 percent as many blood-forming stem cells and up to three times fewer specialized blood progenitors than did the leaner thoracic vertebrae.

In cell culture, the mere presence of adipocytes (fat cells) was enough to reduce proliferation of blood-forming cells. The fat cells seemed to somehow slow the natural cell cycle of the blood stem cells and progenitor cells.

"Our study contradicts the classical dogma that bone marrow adipocytes are merely space fillers," says Daley. "Rather, they make it harder to recover from chemotherapy or radiation because they actively suppress blood production. If we could prevent them from invading the bone marrow, patients might be able to recover faster from marrow and cord-blood transplants."

Mice that were treated with a compound that inhibits fat formation, or that were genetically incapable of forming fat cells, were quicker to build up their bone marrow after it was depleted by irradiation. In particular, they were quicker to build up the rapidly proliferating blood cell progenitors that are known in mice as well as humans to be the most important in surviving the immediate post-transplant period.

Several adipocyte inhibitors, such as PPAR-gamma inhibitors, are already being tested clinically against obesity, but might also serve as adjuvants to speed engraftment and recovery of the blood system after a bone marrow transplant, Daley says.

"We are now testing whether these anti-obesity drugs have a beneficial effect on blood formation in mice," says Naveiras. Meanwhile, further studies will address exactly how adipocytes inhibit blood formation at the molecular level.


'/>"/>

Contact: Bess Andrews
elizabeth.andrews@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Related medicine news :

1. Frost & Sullivan: Replacement of Old Equipment Boosts Kenyan Medical Imaging Industry
2. Brain Imaging Study Confirms Cognizin(R) Citicoline Boosts Mental Function; to be Presented at International Society of Sports Nutrition Annual Conference
3. Twitter Boosts CNN Reporter's Fight to Save Her Brother's Life
4. Early Exercise Boosts Outcomes for ICU Patients
5. CPAP Therapy Boosts Cardiac Surgery Outcomes
6. Ingredient in Probiotic Sweetener Boosts Immune System
7. Family History of Asthma Boosts Odds Almost 6 Times
8. Grapefruit Juice Boosts Anti-Cancer Drugs Effects
9. Grapefruit juice boosts drugs anti-cancer effects
10. Writing About Values Boosts Grades for Middle Schoolers
11. Radiation-Chemo Combo Boosts Lung Cancer Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... ... July 25, 2017 , ... Centurion Service Group ... Regional Account Manager for the Northeast and Florida regions. In this role, Jennifer ... obsolete medical assets. , Jennifer joins Centurion with a wealth of knowledge and ...
(Date:7/25/2017)... Texas (PRWEB) , ... July 25, 2017 , ... ... fastest growing ATM provider in the United States, today announced its partnership with ... financial institutions. , The foundation of the solution lies within Hyosung’s superior ...
(Date:7/24/2017)... ... July 24, 2017 , ... Engineers at the University of Maryland have ... same kind of electrical energy that the body uses. , In ordinary batteries ... flow of electrons out of the battery is generated by moving positive ions from ...
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... ... the federal Substance Abuse and Mental Health Services Administration’s (SAMHSA) State Targeted Response ... California Department of Health Care Services, will facilitate the development of a hub ...
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... Every year, ... invigorating and educational conference, InstructureCon. Each annual event is coupled with a dynamic theme ... with a James Bond theme, Mission: InstructureCon 0017. , To extend their partnership ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... LOS ANGELES , July 12, 2017 CarpalAID is ... without drugs, braces or surgery. Carpal tunnel syndrome affects ... tunnel syndrome at twice the rate of men. The common methods ... steroids, or mobilization with uncomfortable hand braces or gloves. ... CarpalAID is a ...
(Date:7/11/2017)... , July 11, 2017 Zymo Research Corp., also known ... that can quantify biological aging in a precise manner using the myDNAge ... Steve Horvath , a professor of human genetics and biostatistics at the ... School of Public Health , Zymo Research,s proprietary DNAge ™ technology ... ...
(Date:7/11/2017)...  The global market for liquid biopsy diagnostic and ... in 2016.  Although in early stages, the global market ... as a result of the gradual shift towards personalized ... of a significant number of new liquid biopsy tests ... biomarkers to guide treatment decisions. ...
Breaking Medicine Technology: