Navigation Links
Trimming the fat boosts blood recovery after marrow transplant
Date:6/10/2009

Seeking ways to improve blood recovery after chemotherapy or bone marrow transplant, researchers at Children's Hospital Boston have discovered that fat cells, which accumulate in bone marrow as people age, inhibit the marrow's ability to produce new blood cells. Their study, published online June 10 by the journal Nature, suggests that blocking this fatty infiltration could help enhance patients' recovery after transplant.

Patients who have had radiation or chemotherapy show fatty infiltration in their marrow, and it's known that the more fat cells, the less blood-forming activity the marrow engages in. What hasn't been clear is whether the fat cells actually influence blood formation, or simply fill in empty space in the marrow.

Working with mice, researchers led by George Q. Daley, MD, PhD, director of the Stem Cell Transplantation Program at Children's, and Olaia Naveiras, MD, PhD, of the Division of Pediatric Hematology/Oncology at Children's and the Dana-Farber Cancer Institute, looked at marrow from different parts of the skeleton, which vary in fat composition. They found that the relatively fat-rich tail bones had only 25 percent as many blood-forming stem cells and up to three times fewer specialized blood progenitors than did the leaner thoracic vertebrae.

In cell culture, the mere presence of adipocytes (fat cells) was enough to reduce proliferation of blood-forming cells. The fat cells seemed to somehow slow the natural cell cycle of the blood stem cells and progenitor cells.

"Our study contradicts the classical dogma that bone marrow adipocytes are merely space fillers," says Daley. "Rather, they make it harder to recover from chemotherapy or radiation because they actively suppress blood production. If we could prevent them from invading the bone marrow, patients might be able to recover faster from marrow and cord-blood transplants."

Mice that were treated with a compound that inhibits fat form
'/>"/>

Contact: Bess Andrews
elizabeth.andrews@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Frost & Sullivan: Replacement of Old Equipment Boosts Kenyan Medical Imaging Industry
2. Brain Imaging Study Confirms Cognizin(R) Citicoline Boosts Mental Function; to be Presented at International Society of Sports Nutrition Annual Conference
3. Twitter Boosts CNN Reporter's Fight to Save Her Brother's Life
4. Early Exercise Boosts Outcomes for ICU Patients
5. CPAP Therapy Boosts Cardiac Surgery Outcomes
6. Ingredient in Probiotic Sweetener Boosts Immune System
7. Family History of Asthma Boosts Odds Almost 6 Times
8. Grapefruit Juice Boosts Anti-Cancer Drugs Effects
9. Grapefruit juice boosts drugs anti-cancer effects
10. Writing About Values Boosts Grades for Middle Schoolers
11. Radiation-Chemo Combo Boosts Lung Cancer Outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... HealthDay Reporter , TUESDAY, Oct. 11 (HealthDay News) ... write clinical practice guidelines on diabetes and high cholesterol have ... is that compensation by industry on some of these panels ... guideline recommendations," said Dr. Jennifer Neuman, lead author of a ...
... According to a new study in Clinical Gastroenterology ... pain could help physicians know which patients will benefit ... Gastroenterology and Hepatology is the official journal of ... surgeries, or cholecystectomies, are performed annually in the U.S. ...
... , TUESDAY, Oct. 11 (HealthDay News) -- Studies on the ... plagued by design problems, a new report issued by the ... evidence exists that this kind of therapy helps such patients ... to develop definitive guidelines for its use. With traumatic ...
... a regimen once thought to reduce cancer risk ... of a large national study. The finding comes from ... E Cancer Prevention Trial (SELECT). Eric Klein, M.D., chair of ... the lead author. SELECT began in 2001 to test ...
... Reporter , TUESDAY, Oct. 11 (HealthDay News) -- Women who ... both breast and ovarian cancer are more likely to survive ... Those other women include both women with the BRCA1 mutation, ... cancer, and women without either mutation. Researchers ...
... is exploring the ethical challenges that clinicians and ... in the United States. The project is supported by ... Program. Most of the estimated 11 million undocumented ... are ineligible for public insurance programs. They are prohibited ...
Cached Medicine News:Health News:Many on Medical Guideline Panels Have Conflicts of Interest: Study 2Health News:Many on Medical Guideline Panels Have Conflicts of Interest: Study 3Health News:Pain characteristics suggest higher benefit from gallbladder surgery 2Health News:Evidence Lacking That Cognitive Rehab Therapy Helps Brain-Injured Vets 2Health News:Evidence Lacking That Cognitive Rehab Therapy Helps Brain-Injured Vets 3Health News:National study finds vitamin E supplement may increase prostate cancer risk 2Health News:Mutant Gene That Ups Risk for Ovarian Cancer May Aid Survival 2Health News:Mutant Gene That Ups Risk for Ovarian Cancer May Aid Survival 3Health News:Mutant Gene That Ups Risk for Ovarian Cancer May Aid Survival 4Health News:New project examines medical safety net for undocumented patients 2
(Date:12/24/2014)... LEXINGTON, Mass. , Dec. 23, 2014 /PRNewswire/ ... GEVA ), a biopharmaceutical company developing therapeutic products ... European Medicines Agency (EMA) of the Marketing Authorization ... The EMA recently granted the company,s request for ... the EMA,s regulatory review time.   ...
(Date:12/24/2014)... 2014  Lockton Dunning Benefits, the ... the addition of Vice President Kim Foerster ... Pharmacy Consulting team, Excelsior Solutions. ... to the position.  Most recently, she worked as ... Specialty Pharmacy, where she has held various managerial ...
(Date:12/24/2014)... 23, 2014 Tianyin Pharmaceutical Co., Inc. ... in patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), ... announced that the Company achieved the Public Notice ... (GMP) certificate of TPI,s Qionglai Facility (QLF) from ... public notice period is a significant procedure of ...
Breaking Medicine Technology:Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3Kim Foerster Joins Lockton Companies 2TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... Advance Emerging Wireless Health Industry , ... SAN DIEGO , May ... collaboration with GE Healthcare, a global leader in health care technology, ... accelerating wireless health solutions. GE Healthcare has demonstrated innovative leadership in ...
... The Epilepsy Foundation of Georgia is taking steps ... care. The Georgia House voted unanimously to pass HB194 last week ... pharmacies to indicate on the medication bottle if there has been ... and a great "first step" in consumer protection. The Epilepsy Foundation ...
Cached Medicine Technology:West Wireless Health Institute and GE Healthcare to Collaborate on Technology and Educational Initiatives 2West Wireless Health Institute and GE Healthcare to Collaborate on Technology and Educational Initiatives 3West Wireless Health Institute and GE Healthcare to Collaborate on Technology and Educational Initiatives 4Patient Advocacy Group Distributes Wallet Cards to Help Protect Patients from Medication Switching 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: