Navigation Links
Trials begin on potent new hepatitis C drug
Date:5/14/2010

The first clinical trials have started on a new investigational drug, discovered by researchers at Cardiff University, which is being developed to treat infections caused by Hepatitis C virus.

Approximately 170 million people worldwide are affected with Hepatitis C, which can lead to liver cancer, cirrhosis and death. It is the leading cause of liver transplantation in western countries. The current treatment involves two drugs ribavirin and interferon, which has to be given as an injection. Side effects are often severe and lead to patients failing to complete the treatment.

The new drug, INX-189, is taken orally and was first prepared at the Welsh School of Pharmacy in November 2008. Laboratory tests showed it killed 90 per cent of the virus at very low (nanomolar) concentration, making it one of the most potent compounds of its kind developed to date.

US pharmaceutical company Inhibitex, which owns the licence to INX-189 and has been working with the Cardiff team, has now started trials in healthy volunteers to assess the compound's safety. A second trial, which would evaluate the compound's effectiveness on Hepatitis patients, may follow later this year.

Professor Chris McGuigan of the Welsh School of Pharmacy, academic lead on the project, said: "This is still a very early stage of the trials process. However, progress has been encouraging so far, going from the laboratory to human trials within 18 months. We believe that INX-189 offers the possibility of more potency against Hepatitis, more rapid action in the liver, and fewer side effects than existing treatments."


'/>"/>

Contact: Professor Chris McGuigan
McGuigan@Cardiff.ac.uk
44-292-087-4537
Cardiff University
Source:Eurekalert

Page: 1

Related medicine news :

1. Quincy Bioscience Launches HOPETrials.com; Research Studies More Accessible For Participants
2. Accumed Research Associates Expands Capabilities In Phase I and Bioequivalence Clinical Trials
3. Scott & White Healthcare clinical trials target lymphoma, leukemia
4. Almac's North Carolina Facility Continues Growth in Academically Based Clinical Trials
5. MedTrials Launches New Online Training Website: http://core.medtrials.com
6. Experts Urge Fixes for Clinical Trials System in Crisis
7. SWOG cancer trials network awarded over $120 million in NCI grants
8. Almac to Improve Label Approval Process in Clinical Trials
9. Childhood cancer patients enrolled in clinical trials need clearer communication about their role
10. Medical schools partner to tackle barriers to minority participation in cancer clinical trials
11. Abbreviated Trials Yield Misleading Results: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being held on ... Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research for ... Furniture, lives with Parkinson’s disease and is the architect of this informative event to ...
(Date:2/5/2016)... , ... February 05, 2016 , ... After years as ... Hospital Burn Unit, plastic and cosmetic surgeon Dr. Wayne Carman transitioned to chief of ... He successfully completed his first three-year term as chief and began a second three-year ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: each ... longer to access the treadmills. It’s a predictable trend. After the excesses of November ... get in shape by joining gyms, starting new walking or running routines, or signing ...
(Date:2/5/2016)... , ... February 05, 2016 , ... Dr. Justin Scott ... their 2nd Annual No Cost Dental Day to individuals in need. The event is ... of this No Cost Dental Day is to provide dental care to community members ...
(Date:2/5/2016)... ... ... Health and wellness is a topic that should concern all Americans; however, it ... illness. Migraines are a severe form of a headache and often are accompanied by ... pain on their worst enemy, the feeling can last for many hours and be ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  Redwood Scientific Technologies, ... new product designed to help women balance their hormones. ... delivery technology. Jason Cardiff , President ... be able to help the millions of women across ... the effects of imbalanced hormones. Our research and development ...
(Date:2/5/2016)... , Feb. 5, 2016  As people age, ... The multitude of recommended screenings and tests that are ... a priority. However, for the majority of aging individuals, ... health planning. For the 37.5 million American adults who ... the present to make hearing health a 2016 healthy ...
(Date:2/5/2016)... 5, 2016 ... the "Global Musculoskeletal Partnering 2010-2016: Deal ... to their offering. --> ... the "Global Musculoskeletal Partnering 2010-2016: Deal ... to their offering. --> ...
Breaking Medicine Technology: