Navigation Links
Trials begin on potent new hepatitis C drug
Date:5/14/2010

The first clinical trials have started on a new investigational drug, discovered by researchers at Cardiff University, which is being developed to treat infections caused by Hepatitis C virus.

Approximately 170 million people worldwide are affected with Hepatitis C, which can lead to liver cancer, cirrhosis and death. It is the leading cause of liver transplantation in western countries. The current treatment involves two drugs ribavirin and interferon, which has to be given as an injection. Side effects are often severe and lead to patients failing to complete the treatment.

The new drug, INX-189, is taken orally and was first prepared at the Welsh School of Pharmacy in November 2008. Laboratory tests showed it killed 90 per cent of the virus at very low (nanomolar) concentration, making it one of the most potent compounds of its kind developed to date.

US pharmaceutical company Inhibitex, which owns the licence to INX-189 and has been working with the Cardiff team, has now started trials in healthy volunteers to assess the compound's safety. A second trial, which would evaluate the compound's effectiveness on Hepatitis patients, may follow later this year.

Professor Chris McGuigan of the Welsh School of Pharmacy, academic lead on the project, said: "This is still a very early stage of the trials process. However, progress has been encouraging so far, going from the laboratory to human trials within 18 months. We believe that INX-189 offers the possibility of more potency against Hepatitis, more rapid action in the liver, and fewer side effects than existing treatments."


'/>"/>

Contact: Professor Chris McGuigan
McGuigan@Cardiff.ac.uk
44-292-087-4537
Cardiff University
Source:Eurekalert

Page: 1

Related medicine news :

1. Quincy Bioscience Launches HOPETrials.com; Research Studies More Accessible For Participants
2. Accumed Research Associates Expands Capabilities In Phase I and Bioequivalence Clinical Trials
3. Scott & White Healthcare clinical trials target lymphoma, leukemia
4. Almac's North Carolina Facility Continues Growth in Academically Based Clinical Trials
5. MedTrials Launches New Online Training Website: http://core.medtrials.com
6. Experts Urge Fixes for Clinical Trials System in Crisis
7. SWOG cancer trials network awarded over $120 million in NCI grants
8. Almac to Improve Label Approval Process in Clinical Trials
9. Childhood cancer patients enrolled in clinical trials need clearer communication about their role
10. Medical schools partner to tackle barriers to minority participation in cancer clinical trials
11. Abbreviated Trials Yield Misleading Results: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... VitreosHealth ... each Medicare Advantage member’s risk, identify any gaps-in-coding, as well as gaps-in-care ... transform the HCC Risk Adjustment process from a typical fragmented process to ...
(Date:2/22/2017)... ... February 22, 2017 , ... A cylindrical “pipeline” used for ... to reach ones, according to the results of a clinical trial announced Wednesday. ... by Ricardo A. Hanel, MD, PhD, neurovascular surgeon with Baptist Health and Lyerly ...
(Date:2/22/2017)... ... February 22, 2017 , ... Sideline Products participated in the World ... TV host Tom Seay and his production crew. Tom Seay’s program “Best of ... the world. Saddle Sidekicks will be featured on April 6, 2017. After the ...
(Date:2/22/2017)... ... 2017 , ... Using the power of the internet, IdrisArkette.com has managed to ... period of just 24 months, thousands of individuals interested in a medical procedure managed ... “The internet is not getting quieter. In fact it’s becoming noisier by the day. ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ANGLESTRONG , ... Angle, is now available on the App Store and Google Play ... apps for the addiction and recovery industry, partnered with Angle to build ANGLESTRONG. The ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Feb. 22, 2017   Protein Sciences Corporation ... Flublok® Influenza Vaccine , announced today that they ... Influenza Vaccine Introduction (PIVI) and the Mongolian Ministry of ... of the flu.  The doses of Flublok have been ... Mongolia for health care workers, pregnant women, ...
(Date:2/22/2017)... , Feb. 22, 2017 The Senior Care ... U.S. Senate and House of Representatives that will curtail ... Managers (PBMs) -- from extracting retroactive direct and indirect ... care (LTC) pharmacies and the Medicare program. ... (R-WV) and Jon Tester (D-MT), and ...
(Date:2/22/2017)... 22, 2017 Research and Markets has ... Market (Thermometers - Digital, Infrared, Mercury; Trend Indicator):Analysis By Region, By ... ... is forecasted to grow at a CAGR of 5.33% during 2016-2021 ... of infectious diseases along with surging demand of digital thermometer. Apart ...
Breaking Medicine Technology: