Trial to Test Gene Therapy for Angin... (evaluating it in the classic way Moread...)

Trial to Test Gene Therapy for Angina in Women

Date:9/4/2007

evaluating it in the classic way," Moreadith said.

The two earlier clinical trials found that men given a placebo were more likely to report favorable results. Both trials, which included a total of 532 people with angina, were halted when interim analysis of the data showed no overall significant improvement for the entire group. Analysis of subsets of people in the trials led to the current study.

It's not possible to say when results of the current trial will be available, Reinhard said.

The idea of promoting the growth of new blood vessels in the heart "opens a new frontier in the cardiac arena," Reinhard added. Existing treatments for angina are aimed at easing the symptoms of the condition by widening blood vessels, either temporarily with drugs such as nitroglycerin or permanently with procedures such as bypass surgery.

Gene therapy to improve the heart's oxygen supply by inducing development of new blood vessels "deals with the underlying problem," Reinhard explained.

The idea that this therapy could work differently in women makes sense because the physical nature of the condition causing angina is often different in the two sexes, explained Dr. Suzanne Steinbaum, director of women and heart disease at Lenox Hill Hospital in New York City.

In women, diminished blood flow to the heart often is due to general narrowing of many of the arteries feeding the heart, while in men the problem tends to be concentrated in one area, Steinbaum said.

"Women have more diffuse disease, so if you provide more conduits you will have more blood flow and less angina," she said. "With men, the problem is more discrete, so providing more conduits might not relieve symptoms."

"There definitely is something to this that makes sense," Steinbaum said.

In related news, Swedish researchers at the European Society of Cardiology meeting in Vienna suggested on Monday that women with heart disease m
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