Navigation Links
Trial suggests statin may affect markers associated with progression of HIV
Date:2/16/2011

A recent multicenter clinical trial of atorvastatin, a type of cholesterol-lowering drug, found that although the drug did not inhibit plasma HIV RNA levels, it did inhibit expression of cellular markers of immune activation and inflammation in patients with HIV infection. Since immune activation and inflammation are associated with progression of HIV infection, the implication is that the statin may inhibit disease progression and help in the infection's management. The findings are in a study, available online, published in The Journal of Infectious Diseases.

The investigators, led by Anuradha Ganesan, MD, of the National Naval Medical Center and the Infectious Disease Clinical Research Program in the Department of Preventive Medicine and Biometrics at the Uniformed Services University of the Health Sciences in Bethesda, Md., randomized 22 HIV-1-infected patients not on antiretroviral therapy and with cholesterol levels lower than those requiring statin therapy in a double-blind protocol of high-dose drug or placebo for eight weeks. After a four-to-six-week washout phase, each group was switched to the other treatment for another eight weeks.

The primary objective was to study the effect of atorvastatin on plasma HIV-1 RNA levels, as previous studies had shown conflicting results. The effect on cellular markers of immune activation was a secondary objective. HIV-1 RNA levels were not significantly affected by the drug, but levels of such immune activation markers as CD38 and HLA-DR on CD4 and CD8 T cells were reduced.

The researchers noted that their findings with atorvastatin suggest that understanding the mechanism by which statins affect immune markers may identify new approaches for the management of HIV infection. They point out, however, that their trial was not designed to demonstrate clinical benefits, for which larger studies of longer duration are needed.

In an accompanying editorial, Andrew Carr, MD, of
'/>"/>

Contact: John Heys
jheys@idsociety.org
703-299-0412
Infectious Diseases Society of America
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Women More Likely to Fail Treatment for Atrial Fibrillation
2. Single gene mutation induces endometrial cancer
3. NEJM Publishes Trial Results Demonstrating Bard FLAIR Endovascular Stent Graft Is Superior To Balloon Angioplasty For Failing Dialysis Grafts
4. MCG to conduct first FDA-approved stem cell trial in pediatric cerebral palsy
5. In Tests, Implanted Monitor Detects Atrial Fibrillation
6. Almac Launches New STEMS System to Transform Temperature Controlled Shipment Monitoring in Clinical Trials
7. Clinical trial underway: Miniature ultrasound device could revolutionize pain relief
8. Michael J. Fox Foundation Awards $1.1 Million For Clinical Trial of Transdermal Nicotine as Disease-Modifying Treatment For Parkinsons
9. WellPoint/Blue Cross Liver Transplant Denial Trial Starts Monday
10. WellPoint/Blue Cross Liver Transplant Denial Trial Begins Today, Illustrates Need for Toughening of White House Reform Plan
11. Mesothelioma Clinical Trials List Offered by IQ Mesothelioma: Search Current Mesothelioma Treatment Options
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... April 17, 2014 Meaningful long-term survival is ... of the abdomen when treated with cytoreductive surgery ... a first-of-its-size analysis by physicians at Wake Forest ... the largest reported, single-center experience with cytoreductive surgery ... M.D., and analysis of 20 years, worth of ...
(Date:4/17/2014)... than 40 years away from a food shortage that ... to a top scientist at the U.S. Agency for ... food production will be limited on a global scale ... Dr. Fred Davies, senior science advisor for the agency,s ... politically destabilizing by 2050 as energy issues are today.", ...
(Date:4/17/2014)... TORONTO, April 17, 2014While 94 per cent of Canadians ... that screen newborns for a specific number of genetic ... willing to participate in screening that would sequence their ... prick test" in their first day or two of ... taken from their heels and tested for about five ...
(Date:4/17/2014)... whose work has transformed cancer care in Northern Ireland, ... Academy of Cancer Sciences., The Academy, which was launched ... distinguished oncologists and cancer researchers which aims to reduce ... , Professor Johnston, whose leadership has seen cancer survival ... the UK league table to near the top, has ...
(Date:4/17/2014)... research to be carried out into HIV and ... a paper in The Lancet Infectious Diseases ... in the department of Parasitology and researchers from ... of Cambridge and the Royal Veterinary College looked ... HIV/AIDS and schistosomiasis of children, and found that ...
Breaking Medicine News(10 mins):Health News:20 years of data shows treatment technique improvement for advanced abdominal cancer 2Health News:Food shortages could be most critical world issue by mid-century 2Health News:Researcher looks at public perceptions around newborn testing 2Health News:Researcher looks at public perceptions around newborn testing 3Health News:More research called for into HIV and schistosomiasis coinfection in African children 2
... Mich., May 8 A woman in the ... minutes, but finding,breast cancer at an early stage ... of the most important woman in all our ... KitchenAid" is celebrating,Mother,s Day by involving the culinary ...
... Hospital buildings can heal,according to the first comprehensive ... environment on child patients in health care settings. ... the,Physical Environment is produced by the National Association ... with the Center,for Health Design. Findings from the ...
... result of San Diego State,University,s interim suspension ... supports the decisions of our,member fraternities to ... parties accountable for their actions. The NIC, ... with our member organizations and San,Diego State ...
... Empire State Building. The,base camp of Mount Everest. And ... co-founder of Love Hope Strength Foundation, an,international charity hosting ... cancer centers worldwide., In March of 2000, James ... doctors gave him a 50% chance of survival but ...
... Oracle Healthcare,Acquisition Corp. (the "Company") (OTC Bulletin Board: ... dissolution of the Company and,its proposed plan of ... April 16, 2008, at the special meeting of ... announced, the Company has set May 7, 2008 ...
... Telehealth, using telecommunication technology to deliver health ... delivery and availability of health care services to ... patients who received a telehealth intervention from care ... compared to patients who received traditional care. , ...
Cached Medicine News:Health News:Celebrity Chefs and America's Restaurants Cook for the Cure This Mother's Day 2Health News:Celebrity Chefs and America's Restaurants Cook for the Cure This Mother's Day 3Health News:Hospital Buildings Can Heal According to First Comprehensive Report on Impact of Physical Environment on Child Patients 2Health News:Hospital Buildings Can Heal According to First Comprehensive Report on Impact of Physical Environment on Child Patients 3Health News:Hospital Buildings Can Heal According to First Comprehensive Report on Impact of Physical Environment on Child Patients 4Health News:James Chippendale Climbs the Mountain of Life 2Health News:Oracle Healthcare Acquisition Corp. Announces Stockholder Approval of Proposed Dissolution and Plan of Liquidation 2Health News:Patients with chronic illness benefit from telehealth intervention 2
(Date:1/15/2014)... 15, 2014 MultiCell Technologies, Inc. (OTC Bulletin Board: ... patent application concerning composition of matter, biological targets, mechanism ... cell death.  This patent application describes ... RNA molecules (VSRNAs) which interfere with the basic homeostatic ...
(Date:1/15/2014)... GENEVA, Ill. , Jan. 15, 2014 The ... a Medical Fitness Center by the Medical Fitness Association, ... centers to achieve their full potential. The Cadence Fitness ... in the western suburbs and second in the Chicagoland ...
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... & Forecast – Worldwide Analysis ... Pump Market Analysis ...
Breaking Medicine Technology:MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17
... , , ROSH ... of innovative solutions for the advanced chronic,wound management market, ... Food and Drug Administration (FDA) to market its new,SilverStream(TM) ... Over-the-Counter version of the SilverStream product. , ...
... , , , , ... NXTM ), a leading manufacturer of innovative dialysis products, ... and their partners will be embarking on a week-long, conventional ... The cruise, dubbed the "2010 Freedom Cruise: We,re Taking Home ...
Cached Medicine Technology:EnzySurge Receives FDA Approval for SilverStream(TM) Innovative Wound Management Solution 2Group of NxStage(R) Home Hemodialysis Patients to Take Caribbean Cruise with the System One(TM) 2Group of NxStage(R) Home Hemodialysis Patients to Take Caribbean Cruise with the System One(TM) 3Group of NxStage(R) Home Hemodialysis Patients to Take Caribbean Cruise with the System One(TM) 4