Navigation Links
Trial Therapy Improves Melanoma Survival
Date:8/19/2010

plus gp100 (an experimental vaccine that had previously shown some benefit in melanoma cases), ipilimumab alone, or gp100 alone. The study did not have a normal control group in which the survival of patients on ipilimumab was compared to the survival of patients on standard treatment.

Participants received a total of four infusions, at three-week intervals, a much shorter course of therapy than currently available, the study authors said.

"With melanoma there are few approved options for therapy and when we use agents like chemotherapy, people are on drugs forever and there's [only] a short-term benefit," explained Dr. Kari Kendra, a medical oncologist with the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute in Columbus. "With immune modulators like IL-2 or ipilimumab, there's a potential for durable responses."

There was essentially no difference in median survival between the groups taking ipilimumab with or without gp100: about 10 months. This compared with only 6.4 months for those taking gp100 alone, a 68 percent improvement.

"The gp100 vaccine didn't seem to add much to the treatment," Hodi said.

But receiving the IV infusion again if the melanoma looked like it was coming back also provided some benefit, Hodi said.

Fifteen percent of patients receiving ipilimumab experienced serious side effects, compared to only 3 percent receiving gp100 on its own. There were 14 deaths related to the drugs used in the study, and seven of the patients died from problems with their immune system, the researchers reported.

The researchers are now focusing their attention on the patients who survived sometimes as long as six years.

"We're looking at predictive biomarkers to see why some get a greater benefit than others," Hodi said.

Ipilimumab is not yet FDA-approved, so there's no price tag associated with it, although Kendra said she "would
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. CRF announces featured clinical trials to be presented at TCT 2010
2. Clinical trials: Comprehension unaffected by simplified consent forms or payment
3. Clinical trials abroad: Making non-English language consent forms readable
4. Human clinical trial of NIH-developed dengue vaccine begins
5. CRF announces late breaking trials and first report investigations to be presented at TCT 2010
6. Drug trials funded by industry are more likely to publish favorable results
7. Clinical trials can be improved by managing the learning curve
8. Sickle cell treatment developed at LA BioMed enters Phase 3 clinical trial
9. Microbicide trial results a turning point for HIV prevention, says team testing same gel
10. Many False-Positive HIV Test Results for Those in AIDS Vaccine Trials
11. BioSTARTM device achieves 90 percent closure rate for atrial septal defect in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... is an important company in the dress industry. The ... online market share by a series of promotions. Recently, it ... a bridesmaid dress promotion for the new year 2015. The ... dresses from this company are not only of high quality ... good at manufacturing wedding dresses. Customers prefer to choose the ...
(Date:11/22/2014)... 2014 Nocturia is defined by ... that the individual has to wake at night ... “Nocturia – Pipeline Review, H2 2014” provides comprehensive ... with comparative analysis at various stages, therapeutics assessment ... of administration (RoA) and molecule type, along with ...
(Date:11/22/2014)... York (PRWEB) November 22, 2014 A ... morcellators ( http://www.morcellatorlawsuit2015.com ) in minimally-invasive hysterectomies and ... signatures since the end of October, Bernstein Liebhard LLP ... the petition as of November 21st, 2014. That represents ... 86,042 supporters had signed on to the campaign.* , ...
(Date:11/22/2014)... News) -- The wide variety and complexity of foods ... people with food allergies, an expert warns. "Every ... of food allergies that it can be really difficult ... Krishnaswamy, director of allergy and clinical immunology at Wake ... release. "If you know you have food allergies, ...
(Date:11/22/2014)... York, New York (PRWEB) November 22, 2014 ... filed on behalf of patients who allegedly developed Type ... forward in the federal multidistrict litigation now underway in ... LLP reports. According to court documents, the litigation will ... 10:00 a.m. The Court has directed Lead Counsel for ...
Breaking Medicine News(10 mins):Health News:Bridesmaid Dresses Introduced by Famous Company Discount-Dress.com For The New Year 2015 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 2Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 3Health News:Nocturia Therapeutic Pipeline Market Review by Drugs and Companies H2 2014 Report at RnRMarketResearch.com 4Health News:Power Morcellator Petition Gains More than 450 Signatures Since October, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Petition Gains More than 450 Signatures Since October, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Petition Gains More than 450 Signatures Since October, Bernstein Liebhard LLP Reports 4Health News:'Tis the Season of Challenges for Those With Food Allergies 2Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 3
... project to manage the potential shortage of bird flu vaccine ... preparation, would soon be initiated by Chugai Pharmaceutical Company, a ... Health, Labor and Welfare of Japan is said to have ... bird flu vaccine is hoped to being in the next ...
... billion in health reforms. But his off-handed statement has outraged ... there was more mental illness previously which we are not ... on with one’s life. ,This comment was labeled ... he said that in reality mental illness is still considered ...
... bird flu infection in nearly 8 birds, the Hong Kong ... rental system) in possession of animal or bird without prior ... a deduction of five penalty points. ,. ,In ... to pay a fine of 100, 000 HK dollars, according ...
... off at lunch breaks, coughing up ?4,500 for Jiffy breast ... such breast implant operations//, and is getting into the News ... was one of the first to be on their operation ... her mom and a student loan. She said: "You ...
... genetic and environmental factors in the incidence of common ... major research studies// The National Institutes of Health (NIH) ... environment and the disease would form the main focus ... around the significance of genetic variation in increasing or ...
... A new study by Margaret Marshall of Seattle Pacific University ... that the strategy// of expecting the worst results after an ... individuals who adopt such defensive pessimism are not better off ... issue of the journal Cognition and Emotion, the excretes of ...
Cached Medicine News:Health News:NIH To Launch Two Major Gene and Disease Projects Soon 2
(Date:11/22/2014)... , Nov. 22, 2014  New data demonstrates that ... most common form of female sexual dysfunction, Hypoactive Sexual ... or driving performance in premenopausal women when taken at ... Society of North America,s (SMSNA) ... . SMSNA accepted this study ...
(Date:11/22/2014)... , Nov. 21, 2014 MEDITE Group acquired ... nine months and the 3 rd quarter sales ended ... income was $448,000 for the nine months ended September 2014 ... "Even though our 3 rd quarter is usually a ... extends from July into September for many countries worldwide, we ...
(Date:11/21/2014)... Md. , Nov. 21, 2014  The University ... will host the ceremonial groundbreaking of the new A. ... Park. The new building will cultivate transformative new engineering ... Taking place at 10:00 a.m. on November ... the Paint Branch Parking Lot, adjacent to the Jeong ...
Breaking Medicine Technology:Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 2Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 3CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 3University of Maryland Breaks Ground for A. James Clark Hall 2University of Maryland Breaks Ground for A. James Clark Hall 3University of Maryland Breaks Ground for A. James Clark Hall 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: