Navigation Links
Trial Therapy Improves Melanoma Survival
Date:8/19/2010

By Amanda Gardner
HealthDay Reporter

WEDNESDAY, Aug. 18 (HealthDay News) -- An experimental drug for metastatic melanoma prolonged median survival from 6.4 months to 10 months, which, although seemingly small, represents a significant extension of life for this normally intractable disease, a new study found.

And a subgroup of patients given the drug, known as ipilimumab, lived as long as six years, according to research published in the Aug. 19 issue of the New England Journal of Medicine.

This type of skin cancer has an average survival time of six to nine months.

"This is the first drug that's ever been shown in a randomized, controlled trial to offer a survival benefit for patients," said study lead author Dr. F. Stephen Hodi, director of the melanoma disease center at Dana Farber Cancer Institute in Boston.

The findings were first reported in June at the annual meeting of the American Society of Clinical Oncology in Chicago. The study was funded by Bristol-Myers Squibb and its biotechnology subsidiary Medarex, which makes ipilimumab.

Only two drugs have been approved by the U.S. Food and Drug Administration to treat melanoma that has spread beyond its original site: interleukin 2, or IL-2, and dacarbazine. IL-2 is a drug that affects the immune system while dacarbazine is a chemotherapy agent.

There have been no new FDA approvals of drugs for metastatic melanoma in more than a decade.

Ipilimumab is a human monoclonal antibody, which targets an antigen known as CTLA-4 that is found on the surface of T cells, which are blood cells that protect the body from infection.

CTLA-4 inhibits the immune system and "ipilimumab releases the brakes to the immune system," Hodi explained. That way, T cells are free to move throughout the body and attack the melanoma cells.

For this study, 676 patients with advanced melanoma were randomly chosen to receive either ipilimumab
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. CRF announces featured clinical trials to be presented at TCT 2010
2. Clinical trials: Comprehension unaffected by simplified consent forms or payment
3. Clinical trials abroad: Making non-English language consent forms readable
4. Human clinical trial of NIH-developed dengue vaccine begins
5. CRF announces late breaking trials and first report investigations to be presented at TCT 2010
6. Drug trials funded by industry are more likely to publish favorable results
7. Clinical trials can be improved by managing the learning curve
8. Sickle cell treatment developed at LA BioMed enters Phase 3 clinical trial
9. Microbicide trial results a turning point for HIV prevention, says team testing same gel
10. Many False-Positive HIV Test Results for Those in AIDS Vaccine Trials
11. BioSTARTM device achieves 90 percent closure rate for atrial septal defect in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... News) -- Longer and colder body cooling does not reduce ... from a lack of oxygen, a new study finds. ... condition -- called hypoxic ischemic encephalopathy -- can be reduced ... Fahrenheit) for 72 hours, experts say. Research has shown ... so this study examined if the same would be true ...
(Date:12/24/2014)... Dec. 23, 2014 (HealthDay News) -- Though most patients ... medication and therapy, between 10 percent to 20 percent ... to standard care, experts say. However, patients with ... form of a type of brain surgery that disables ... The challenge: to distinguish between patients most likely to ...
(Date:12/24/2014)... you are a high-risk heart patient, you might be ... cardiologist, new research suggests. Survival rates among these ... professional meetings, Harvard researchers report. Sixty percent of ... teaching hospital during one of these meetings died within ... were not taking place. "That,s a tremendous reduction ...
(Date:12/22/2014)... December 22, 2014 As part ... senior care service in San Diego and ... of its senior care team with ongoing online ... Golden Care is provided by Caregiverlist®. Caregiverlist® ... caregivers with the most reliable eldercare options, highest ...
(Date:12/22/2014)... Los Angeles, CA (PRWEB) December 22, 2014 ... the names have changed. The reason why most fad ... work - temporarily. The problem with fad diets is that, ... loss tapers, leaving the dieter uncertain of how to reset ... mode. For this reason, Diet Doc developed their all-inclusive ...
Breaking Medicine News(10 mins):Health News:Greater Cooling of Oxygen-Deprived Infants Fails to Improve Survival 2Health News:Scans May Spot People Who'll Benefit From Surgery for OCD 2Health News:When Heart Docs Are Away, Their High-Risk Patients May Fare Better 2Health News:When Heart Docs Are Away, Their High-Risk Patients May Fare Better 3Health News:Golden Care Partners with Nationally Recognized Caregiver Training Service 2Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 2Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 3Health News:Diet Doc Announces the Difference Between Fad Diets and Real Weight Loss Programs to Help Dieters Make the Best Choice 4
... Minyard Food Stores Inc. is offering any,expectant mom ... Life Healthy(TM)" initiative, the company announced,today., Just in ... will,offer free prenatal vitamins to all expectant mothers for ... any Carnival, Minyard or,Sack,n Save store in North Texas. ...
... and other hospital and healthcare advocates from across the,state ... protest the nearly $300,million in healthcare cuts proposed in ... Gone Tomorrow," a Rally to Preserve Our Healthcare, ... WHEN: 12 noon, May 12, The "Care Today, ...
... Consumer,Healthcare, marketer of the leading smoking cessation products ... applauds,the release of the updated 2008 U.S. Public ... Dependence. Too many smokers lower their,chances of quitting ... The Guideline is an important validation of the ...
... Vaccinogen Inc. said Dutch health,authorities licensed it to manufacture ... to more than $100 million of,potential European sales., ... Emmen, The,Netherlands also paves the way to its pivotal ... before the vaccine can be sold in the United,States., ...
... 7 Hamline University School of Law,s,Health Law Institute ... offer a Health Care Corporate Compliance Certificate,education program. Hamline,s ... the Upper Midwest and one of only four programs ... program is designed to be completed within,one year, with ...
... studies indicate improved IVF procedures may spare patients money & ... ... Calif., May 7 Spurred by recent research,California fertility specialists are ... -- saying newer,and improving in vitro fertilization (IVF) technology tends to ...
Cached Medicine News:Health News:Expectant Moms Offered Free Prenatal Prescription Vitamins at D-FW Area Carnival, Minyard and Sack'n Save Stores 2Health News:A Statement from GlaxoSmithKline Consumer Healthcare on 2008 Update to the U.S. Public Health Service Guideline on Treating Tobacco Use and Dependence 2Health News:A Statement from GlaxoSmithKline Consumer Healthcare on 2008 Update to the U.S. Public Health Service Guideline on Treating Tobacco Use and Dependence 3Health News:Dutch Authorize Manufacture of Vaccinogen's New Cancer Vaccine; License Clears Path to European Production, Final FDA Trial 2Health News:Fertility Doctors: Studies Suggest Artificial Insemination Increasingly Second Choice 2
(Date:12/22/2014)... and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has announced ... Market" report to their offering. ... focuses on the developments in the self-monitoring blood glucose ... Reimbursement analysis and the effects of competitive bidding have ... SMBG meters have been performed, based on the various ...
(Date:12/22/2014)... -- Cyberonics, Inc. (NASDAQ: CYBX ), a global ... epilepsy, today announced it will participate in the 33 rd ... 2015, in San Francisco . ... will speak at 11:00 AM Pacific Time.  A live audio ... the Investor Relations link on the Cyberonics home page at ...
(Date:12/22/2014)... ALTO, Calif. , Dec, 22, 2014 /PRNewswire/ ... a Phase 2a study of lonafarnib in patients ... study was conducted at the National Institutes of ... Maryland .  The double-blinded, randomized, placebo-controlled, dose ... mg twice daily and 200 mg twice daily ...
Breaking Medicine Technology:US Self-monitoring Blood Glucose Market 2Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 2Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 3
... 2011   Radiotherapy Clinics of Georgia has announced the ... physicians of Radiotherapy Clinics of Georgia in January.  These courses ... and treatment options. All Prostate Cancer Lecture Series ... a light dinner at 5 p.m. followed by a lecture ...
... Md., Dec. 16, 2011 The U.S. Food and Drug ... heart of children with heart failure to help keep them ... found. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... Pediatric System, made by a German company, Berlin Heart. The ...
Cached Medicine Technology:Radiotherapy Clinics of Georgia Present Prostate Cancer Lecture Series 2FDA Approves Mechanical Cardiac Assist Device for Children With Heart Failure 2FDA Approves Mechanical Cardiac Assist Device for Children With Heart Failure 3
... aerosol contamination, which causes ... PCR. Hydrophobic, nonwicking and ... can pass through these ... contrast to tips with ...
Inquire...
... are ideal for PCR and ... any work where aerosol contamination ... for pipetting DNA/RNA solutions, infectious ... For applications requiring absolute sterility, ...
... Finntip Filters are ideal ... methods, or for any work ... They are designed for pipetting ... samples, and other. For applications ...
Medicine Products: