Navigation Links
Treatment-resistant epilepsy common in idiopathic autism
Date:4/18/2011

A new study found that treatment-resistant epilepsy (TRE) is common in idiopathic autism. Early age at the onset of seizures and delayed global development were associated with a higher frequency of resistance to antiepileptic drugs (AEDs). Full findings appear online in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE).

According to the Centers for Disease Control and Prevention (CDC), autism spectrum disorders (ASDs) are a group of developmental disabilities that can significantly impact social interaction, communication and behavior. The CDC estimates that on average, 1 in 110 U.S. children has an ASD (which is four times more likely to develop in boys than in girls). Medical evidence suggests that the prevalence of epilepsy in autism ranges from 7% to 46%.

Researchers on the present study team, led by Orrin Devinsky, M.D., Professor of Neurology, Neurosurgery, and Psychiatry at NYU School of Medicine and Director of the NYU Comprehensive Epilepsy Center in New York, reviewed clinical and laboratory data for patients with idiopathic autism evaluated at the Center during a 20-year period. Seizures were classified using ILAE criteria, with treatment resistance defined as failure of adequate trials of two tolerated AED regimens. "Treatment-resistant epilepsy is common among patients with autism, and more than one-third of patients in our study group had TRE," said Dr. Devinsky. "Among patients for whom we had complete AED and seizure control data, 55% had TRE."

Among the 127 patients with autism and at least one epileptic seizure, 34% had TRE and 28% were seizure-free. The remaining 39% of patients with autism and epilepsy had infrequent seizures or insufficient data to properly categorize them. In patients with TRE, researchers found that seizure onset was at an earlier age than in patients who were seizure free. TRE patients also had more developmental regression, as well as motor and language delays, than seizure-free participants.

Three patients had surgical resection and one underwent anterior callosotomy; these surgical treatments provided little or no improvement in seizure status. In nine patients with vagus nerve stimulator (VNS) implantation, limited improvement of seizures was noted in two patients and no improvement in seven patients. "In patients with autism, we found that surgical and VNS outcomes were less favorable, providing a lower rate of seizure freedom, than in other TRE populations," concluded Dr. Devinsky. "Further studies are needed to explore the association between chronic epilepsy and autism."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. New drug shows potential for treatment-resistant leukemia
2. Ketamine Eased Depression in Treatment-Resistant Bipolar Disorder
3. Patients with treatment-resistant CLL respond positively to stem cell transplants
4. Study finds treatment-resistant ringworm prevalent among children in metro elementary schools
5. Having Both Autism and Epilepsy Linked to Raised Death Rates
6. Mortality rate is increased in persons with autism who also have epilepsy
7. People With Epilepsy More Prone to Brain Tumors: Study
8. New direction for epilepsy treatment
9. Gender May Play Role in Psych Symptoms in Kids With Epilepsy
10. Mayo Clinic researchers find cardiac pacing helps epilepsy patients with ictal asystole
11. Epilepsy-linked memory losss worries more patients than doctors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... 02, 2016 , ... "Pro3rd Accents Volume 2 is a set of 30 ... titles with just a few clicks of the mouse," said Christina Austin - CEO ... animations. Choose from various styles with accented animations, rigid boxes, simplistic lines, and more. ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... Scientist & Author of Type 2 Diabetes: The Owner’s Manual, http://realtimepressrelease.com/press-releases-tagged-with/daryl-wein ... Kleyne Hour Power of Water, Global Climate Change and Your Health radio program ...
(Date:11/30/2016)... ... November 30, 2016 , ... "I hate when the mixture of saliva and ... said an inventor from Bridgewater, N.J. "I thought that there had to be a ... He developed the patent-pending DEFLECTOR to prevent saliva and toothpaste from running down the ...
(Date:11/30/2016)... (PRWEB) , ... November 30, 2016 , ... ... treating injured workers have been a focus of public policymakers and system stakeholders ... Research Institute (WCRI) released its Medical Price Index for Workers’ Compensation, Eighth ...
(Date:11/30/2016)... Atlanta, Georgia (PRWEB) , ... November 30, 2016 ... ... ODS Security Solutions (ODS), a leading provider of security services based in Richmond, ... , ODS is greatly admired for providing outstanding quality security services and prides ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016  Maxor National Pharmacy Services, LLC ("Maxor"), today announced ... ("PSI").  The combination of Texas -based Maxor ... PSI bring together both company,s clinical expertise and high-touch patient ... industry-leading specialty pharmacy. About Maxor ... , , ...
(Date:12/2/2016)... 2016 Lianluo Smart Limited (Nasdaq: ... which develops, markets and sells medical devices and ... and international markets, recently attended the ... New Progress Forum, co-hosted by the Institute of ... , Guangdong Provincial People,s Hospital and Cardiology Department ...
(Date:12/2/2016)... The concept of rare diseases and the idea that a ... been taking shape in Europe since ... related to orphan medicinal products have been emerging at both ... individually. Many member states in the EU have led the ... products, the result of which took the shape of the ...
Breaking Medicine Technology: