Navigation Links
Treatment-resistant epilepsy common in idiopathic autism
Date:4/18/2011

A new study found that treatment-resistant epilepsy (TRE) is common in idiopathic autism. Early age at the onset of seizures and delayed global development were associated with a higher frequency of resistance to antiepileptic drugs (AEDs). Full findings appear online in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE).

According to the Centers for Disease Control and Prevention (CDC), autism spectrum disorders (ASDs) are a group of developmental disabilities that can significantly impact social interaction, communication and behavior. The CDC estimates that on average, 1 in 110 U.S. children has an ASD (which is four times more likely to develop in boys than in girls). Medical evidence suggests that the prevalence of epilepsy in autism ranges from 7% to 46%.

Researchers on the present study team, led by Orrin Devinsky, M.D., Professor of Neurology, Neurosurgery, and Psychiatry at NYU School of Medicine and Director of the NYU Comprehensive Epilepsy Center in New York, reviewed clinical and laboratory data for patients with idiopathic autism evaluated at the Center during a 20-year period. Seizures were classified using ILAE criteria, with treatment resistance defined as failure of adequate trials of two tolerated AED regimens. "Treatment-resistant epilepsy is common among patients with autism, and more than one-third of patients in our study group had TRE," said Dr. Devinsky. "Among patients for whom we had complete AED and seizure control data, 55% had TRE."

Among the 127 patients with autism and at least one epileptic seizure, 34% had TRE and 28% were seizure-free. The remaining 39% of patients with autism and epilepsy had infrequent seizures or insufficient data to properly categorize them. In patients with TRE, researchers found that seizure onset was at an earlier age than in patients who were seizure free. TRE patients also had more developmental regression, as well as motor and language delays, than seizure-free participants.

Three patients had surgical resection and one underwent anterior callosotomy; these surgical treatments provided little or no improvement in seizure status. In nine patients with vagus nerve stimulator (VNS) implantation, limited improvement of seizures was noted in two patients and no improvement in seven patients. "In patients with autism, we found that surgical and VNS outcomes were less favorable, providing a lower rate of seizure freedom, than in other TRE populations," concluded Dr. Devinsky. "Further studies are needed to explore the association between chronic epilepsy and autism."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. New drug shows potential for treatment-resistant leukemia
2. Ketamine Eased Depression in Treatment-Resistant Bipolar Disorder
3. Patients with treatment-resistant CLL respond positively to stem cell transplants
4. Study finds treatment-resistant ringworm prevalent among children in metro elementary schools
5. Having Both Autism and Epilepsy Linked to Raised Death Rates
6. Mortality rate is increased in persons with autism who also have epilepsy
7. People With Epilepsy More Prone to Brain Tumors: Study
8. New direction for epilepsy treatment
9. Gender May Play Role in Psych Symptoms in Kids With Epilepsy
10. Mayo Clinic researchers find cardiac pacing helps epilepsy patients with ictal asystole
11. Epilepsy-linked memory losss worries more patients than doctors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... PITTSBURGH, Pa. (PRWEB) , ... October 13, 2017 , ... ... the dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a ... access to medication in darkness or restricted lighting. As such, it eliminates the need ...
(Date:10/13/2017)... Las Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... of 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum ... CBD dose required and providing a CBD form that can be easily incorporated into ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
Breaking Medicine Technology: