Navigation Links
Treatment for alcohol dependence might work best in certain populations, research suggests
Date:3/16/2011

This release is available in French.

MONTREAL March 16, 2011 - Results from a new study suggest that one of the most prescribed medications for alcohol dependence may be more effective in some people. Preliminary results show that naltrexone (Revia), one of the only medications approved for treating people with alcohol abuse problems, may only be effective in women and those with a specific genetic variation. The new study, conducted by researchers from the Research Institute of the McGill University Health Centre (RI MUHC) and McGill University, will be published in the journal Alcoholism: Clinical and Experimental Research.

Previous work suggested that naltrexone only helped some people with alcohol problems, but the reason for that was unclear. "Our results suggest that we might now be able to predict beforehand who will benefit most," says Dr. Marco Leyton, lead investigator of the study and a researcher in the Mental Illnesses and Addiction axis at the RI MUHC. "We were quite excited to find that our results supported that naltrexone was specifically effective in women and in people who carried a gene related to the brain's natural morphine system called the mu opioid receptor gene (OPRM1)."

In this study, researchers followed a small group of "social drinkers" in an effort to validate some very preliminary hints that the efficacy of the treatment might be related to gender and a particular gene that may be inherited. These findings could help ensure that we give the right medication to the right people," says Dr. Leyton, who is also and associate professor in the Department of Psychiatry at McGill.

Researchers and clinicians might be able to determine who might best respond to this treatment, before it was administrated. "If a particular individual with alcohol dependence had these features, we could then say with much more confidence that this is going to help you. For other individuals who don't have those features, we'll be able to say, don't waste your time with this medication, we should try something else for you", explains Dr. Leyton. "These findings have the potential to improve the quality of treatment for alcohol dependent patients and they could ultimately lead to a form of personalized medicine."

Alcohol stimulates the release of the brain's natural opioids, which conveys a feeling of euphoria in individuals when drinking alcohol. There seem to be individual differences in the magnitude of that effect as well as in the sensitivity of the receptors to those natural opioids. "In other words, an opioid receptor blocker, such as naltrexone, might be an effective treatment for people with alcohol problems by decreasing the euphoria of drinking," explains Ms. Elaine Setiawan, first author of the study and PhD candidate in McGill's Integrated Program in Neuroscience.

At this point there is no particular reason to think that these findings couldn't be applied to other groups, such as those with a family history of alcoholism or those with high alcohol craving. But as Dr. Leyton suggests, "further research needs to be done in all sorts of populations and with a much larger sample to better understand the connection between the brain's opioid system, genetics and different responses to naltrexone."


'/>"/>

Contact: Julie Robert
julie.robert@muhc.mcgill.ca
514-843-1696
McGill University Health Centre
Source:Eurekalert

Related medicine news :

1. Herbal Derivative Wins Praise as Malaria Treatment
2. Chasing the pot of gold: WSU researchers study gambling subtypes and treatment outcomes
3. Unusual treatment of colonic perforation
4. Potential new treatment to reduce the burden of atherosclerosis in acute coronary syndrome patients
5. New insights into cancer treatment
6. Research shows rapid adoption of newer, more expensive prostate cancer treatments
7. UTHealth study: Stem cells may provide treatment for brain injuries
8. University of Michigan Cardiovascular Center studies new treatment for high-risk aortic patients
9. ADAM-12 gene could hold key to cancer, arthritis and cardiac treatments
10. Research study explores gene therapy treatment to reduce symptoms of Parkinsons disease
11. The safety of daily magnesium oxide treatment for children with chronic constipation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... ... For breast cancer clinicians and researchers who were unable to attend the 2016 ... and analysis of its highlights, a novel half-day, complimentary meeting—the 14th Annual Best of ... 4, 2017 in Chicago. Chaired by Kathy S. Albain, MD, FACP, FASCO from the ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... at the National Association of Music Merchants (NAMM) winter trade show, Booth #2876, ... , Etymotic’s ER•4® has long been the gold standard for high-definition, in-ear earphones. ...
(Date:1/17/2017)... Louisiana (PRWEB) , ... January 17, 2017 , ... ... Senior Medical Center joined the Peoples Health network on Dec. 1, 2016. ... beneficiaries. , “JenCare Senior Medical Center is an exciting addition to our provider ...
(Date:1/17/2017)... ... January 17, 2017 , ... Wettstein Agencies, a Denver area ... professionals throughout central Colorado, is joining local nonprofit Aurora Warms The Night to ... Night organization is committed to breaking the cycle of homelessness and poverty affecting ...
(Date:1/17/2017)... ... January 17, 2017 , ... The Sharie Withers ... has announced the latest beneficiary of their thriving community involvement program. The current ... to fulfilling the dreams of terminally ill patients. Donations to this worthy cause ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... MIAMI , January 18, 2017 ... announced the company plans to publish an online ... the Company,s preliminary sales forecast for 2017. Management ... Company,s trialing ninety-day record sales performance from its ... recently announced entry into the Cannabis sector ...
(Date:1/18/2017)... Drug Administration CSL CureVac Daiichi Sankyo ... Administration FORT Fresenius Pharmaceuticals Gamma Vaccines ... GlaxoWellcome Global Influenza Programme Grippol ... Systems Indian Association of Paediatrics Janssen Pharmaceuticals ... Krka Pharmaceuticals Medicago Medicare MedImmune ...
(Date:1/17/2017)... DUBLIN , Jan 17, 2017 Research ... Pancreas Devices System Market 2016-2020" report to their offering. ... The global artificial ... during the period 2016-2020. Global Artificial Pancreas Devices System ... with inputs from industry experts. The report covers the market landscape ...
Breaking Medicine Technology: