Navigation Links
Treatment Bias Can Skew Results of Observational Studies

Researchers suggest cancer studies like this should be viewed with caution

MONDAY, April 21 (HealthDay News) -- Certain biases may compromise the findings of observational studies that compare the outcomes of different cancer treatments, a new study shows.

Researchers at the University of Texas M.D. Anderson Cancer Center in Houston said observational studies should include more thorough information and should be better designed to minimize inaccuracies.

Randomized clinical trials -- in which patients are randomly selected to receive different treatments or a placebo -- are considered the gold standard for determining the effectiveness of new cancer treatments, according to background information in the study. Observational studies involve analysis of population-based data to determine how well patients respond to particular drugs.

In this study, the researchers looked at the effectiveness of different cancer therapies for prostate and colon cancer by examining data from the Surveillance, Epidemiology and End Results (SEER) Tumor Registry, a U.S. national population-based cancer registry.

In all cases, the researchers came up with improbable results. They said this shows how easy it is to generate questionable findings when doing an observational study.

They said the skewed results in their three analyses were caused by selection biases when cancer patients are treated. Selection bias can occur when patients with poorer prognoses are more likely to receive a more effective drug, or when patients with better underlying health are more likely to receive a more toxic treatment, because they're more likely to be able to tolerate it.

The researchers said their findings "suggest that the results of observational studies of treatment outcomes should be viewed with caution."

At a minimum, researchers analyzing observational data should attempt to separate patient outcomes into those that could possibly be due to treatment versus those that could not, the study authors concluded. They noted that many observational studies on cancer treatments only report death rates from all causes and don't specify cancer-related deaths.

The study is published in the June 1 issue of Cancer.

More information

The U.S. National Cancer Institute has more about cancer clinical trials.

-- Robert Preidt

SOURCE: American Cancer Society, news release, April 21, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New treatment effective in counteracting cocaine-induced symptoms
2. New treatment boosts muscle function in myasthenia gravis
3. Broad-based group of physicians calls for improvement in stroke treatment
4. Cranberry Could Juice Up Ovarian Cancer Treatment
5. Non-medicinal treatment touted for pre-schoolers with ADHD
6. Nonmedicinal treatment touted for preschoolers with ADHD
7. U of M study: Early treatment can reverse heart damage
8. Biologic treatment for rheumatoid arthritis and the risk of cancer
9. New Treatment Explored for Cluster Headaches
10. Thailand: Partners Open Free AIDS Treatment Clinic in Renowned AIDS Temple in Lop Buri
11. 4-Star Gen. Barry Mccaffrey, Former U.S. Drug Czar, to Keynote Recovery Happens! Rally for Treatment: Wed., Sept. 5, 11 Am, State Capitol West Steps, Sacramento
Post Your Comments:
Related Image:
Treatment Bias Can Skew Results of Observational Studies 
(Date:11/27/2015)... ... November 27, 2015 , ... Dr. Thomas Dunlap and Dr. ... Tucker Bierbaum with Emergency Medicine at St., Joseph Health System’s Santa Rosa Memorial ... conditions present in similar ways and require time-critical intervention to avoid large area heart ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... Q-Suite, announces the incorporation of Asterisk 11 LTS (Long Term Support) into its ... 11 LTS brings Q-Suite 5.10 up-to-date with a version of Asterisk that will ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think Thanksgiving, they also think ... during the Black Friday and Cyber Monday massage chair sales to receive ... high and low to find the best massage chair deals, they can see all ...
(Date:11/26/2015)... ... November 26, 2015 , ... Somu Sivaramakrishnan announced today ... owner, Somu now offers travelers, value and care based Travel Services, including exclusive ... as well as, cabin upgrades and special amenities such as, shore excursions, discounted ...
(Date:11/26/2015)... ... ... Jobs in hospital medical laboratories and in the imaging field lead the many ... Medical Group . These fields, as well as travel nursing, ranked at ... through the company’s website, , The leading healthcare staffing agency released ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... , Nov. 27, 2015  Lannett Company, ... it has completed the acquisition of Kremers Urban ... subsidiary of global biopharmaceuticals company UCB S.A. (Euronext: ... Lannett has acquired KU from UCB for ... certain adjustments, including a customary working capital adjustment, ...
(Date:11/26/2015)... 2015 Un nuevo enfoque combina ... el cáncer avanzado.   --> Un ... de Bremachlorin para el cáncer avanzado.   ... con la terapia fotodinámica de Bremachlorin para el cáncer ... --> Clinical Cancer Research . --> ...
(Date:11/26/2015)... 26, 2015 --> ... SyMRI to find optimal contrast weighting of MRI for ... has signed a research agreement with SyntheticMR in order to ... SyMRI, it is possible to generate multiple contrast images from ... patient has left, thus making it possible to both fine ...
Breaking Medicine Technology: