Navigation Links
Treatment Bias Can Skew Results of Observational Studies
Date:4/21/2008

Researchers suggest cancer studies like this should be viewed with caution

MONDAY, April 21 (HealthDay News) -- Certain biases may compromise the findings of observational studies that compare the outcomes of different cancer treatments, a new study shows.

Researchers at the University of Texas M.D. Anderson Cancer Center in Houston said observational studies should include more thorough information and should be better designed to minimize inaccuracies.

Randomized clinical trials -- in which patients are randomly selected to receive different treatments or a placebo -- are considered the gold standard for determining the effectiveness of new cancer treatments, according to background information in the study. Observational studies involve analysis of population-based data to determine how well patients respond to particular drugs.

In this study, the researchers looked at the effectiveness of different cancer therapies for prostate and colon cancer by examining data from the Surveillance, Epidemiology and End Results (SEER) Tumor Registry, a U.S. national population-based cancer registry.

In all cases, the researchers came up with improbable results. They said this shows how easy it is to generate questionable findings when doing an observational study.

They said the skewed results in their three analyses were caused by selection biases when cancer patients are treated. Selection bias can occur when patients with poorer prognoses are more likely to receive a more effective drug, or when patients with better underlying health are more likely to receive a more toxic treatment, because they're more likely to be able to tolerate it.

The researchers said their findings "suggest that the results of observational studies of treatment outcomes should be viewed with caution."

At a minimum, researchers analyzing observational data should attempt to separate patient outcomes into those that could possibly be due to treatment versus those that could not, the study authors concluded. They noted that many observational studies on cancer treatments only report death rates from all causes and don't specify cancer-related deaths.

The study is published in the June 1 issue of Cancer.

More information

The U.S. National Cancer Institute has more about cancer clinical trials.



-- Robert Preidt



SOURCE: American Cancer Society, news release, April 21, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New treatment effective in counteracting cocaine-induced symptoms
2. New treatment boosts muscle function in myasthenia gravis
3. Broad-based group of physicians calls for improvement in stroke treatment
4. Cranberry Could Juice Up Ovarian Cancer Treatment
5. Non-medicinal treatment touted for pre-schoolers with ADHD
6. Nonmedicinal treatment touted for preschoolers with ADHD
7. U of M study: Early treatment can reverse heart damage
8. Biologic treatment for rheumatoid arthritis and the risk of cancer
9. New Treatment Explored for Cluster Headaches
10. Thailand: Partners Open Free AIDS Treatment Clinic in Renowned AIDS Temple in Lop Buri
11. 4-Star Gen. Barry Mccaffrey, Former U.S. Drug Czar, to Keynote Recovery Happens! Rally for Treatment: Wed., Sept. 5, 11 Am, State Capitol West Steps, Sacramento
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Treatment Bias Can Skew Results of Observational Studies 
(Date:2/24/2017)... ... February 24, 2017 , ... WHAT: ... networking and recognition opportunities as well as advocacy for the state and region‘s ... on February 23. The Council's Innovation Forecast event highlights innovation throughout the ...
(Date:2/24/2017)... ... , ... With millions of Americans and people worldwide struggling ... are aware of our options and are empowered with strength and information throughout ... its newest edition of "Vision and Hearing" in USA Today, that will educate ...
(Date:2/24/2017)... , ... February 24, 2017 , ... Yisrayl Hawkins, Pastor ... on Bible Prophecy concerning this present generation. Yisrayl makes an astounding statement when ... generation. He explains that the Bible details the current times so plainly that ...
(Date:2/24/2017)... ... February 24, 2017 , ... Congratulations to ... Elite division on February 12th. Ms. Esparza qualified into this prestigious status ... competition held in Las Vegas, Nevada. Frida is one of approximately 25 gymnasts ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... to funding innovative lymphoma research and serving the lymphoma community through a comprehensive ... the La Gorce Country Club in Miami Beach to host its Swirl: Miami ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... YORK , Feb. 23, 2017  The ... 330.6 million by 2021 from USD 275.9 million ... Read the full report: http://www.reportlinker.com/p04718602-summary/view-report.html ... increasing spending on pharmaceutical R&D, and growth in ... driving the market growth for particle counters. On ...
(Date:2/23/2017)... , Feb 23, 2017 Research and Markets ... Price Analysis and Strategies - 2016" report to their offering. ... The latest ... provides drug pricing data and benchmarks in the global Autism Spectrum ... What are the key drugs marketed for Autism ...
(Date:2/23/2017)... CITY, Calif., Feb. 23, 2017 Nevro Corp. (NYSE: ... evidence-based solutions for the treatment of chronic pain, today reported ... December 31, 2016. 2016 Accomplishment & Highlights: ... full year 2016, an increase of 228% as reported, over ... for 2016, an increase of 612% over the prior year ...
Breaking Medicine Technology: