Navigation Links
Treating drug resistant cancer through targeted inhibition of sphingosine kinase
Date:8/9/2012

Scientists at Tulane University School of Medicine, led by Dr. James Antoon and Dr. Barbara Beckman, have characterized two drugs targeting sphingosine kinase (SK), an enzyme involved in cancer growth and metastasis. New treatments specifically attacking cancer cells, but not normal ones, are critical in the fight against cancer. The results, which appear in the July 2012 issue of Experimental Biology and Medicine, demonstrate the role of SK in drug resistance and therapeutic potential of SK inhibitors.

"Sphingosine kinase is a relatively new molecular target," says Dr. Beckman "In this study, we show that overexpression of SK promotes resistance to first-line breast cancer therapies, such as tamoxifen. We further found that treatment with the sphingosine kinase inhibitors SKI-II and ABC294640 induced cell death and blocked drug-resistant tumor growth without similar effects in a model system representing relatively normal breast cells."

Molecular therapies, such as those targeting SK, have the potential to improve treatment response rates while simultaneously decreasing side effects. However, Dr. Antoon cautions that "while these results are promising, further study is needed to fully understand the benefits and risks associated with treating drug resistant cancer with these SK inhibitors."

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "Dr. Antoon, Dr. Beckman and colleagues present exciting results indicating the need for further study of inhibitors of sphingosine kinase as promising new cancer treatments".


'/>"/>
Contact: Dr. James Antoon
jantoon@tulane.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Study Suggests Treating Dyslexia Before Kids Learn to Read
2. New standards for treating traumatic shoulder injuries to improve patient care
3. Treating childhood obesity: A family affair
4. Unique physiology key to diagnosing and treating diabetes in Asian populations
5. Studies See Advances in Detecting, Treating Pancreatic Cancer
6. 1 size doesnt fit all when treating blood pressure in people with diabetes, VA/U-M study suggests
7. Nanomedicines promise fewer side effects in treating cancer
8. Mount Sinai researchers develop a multi-target approach to treating tumors
9. A non-antibiotic approach for treating urinary tract infections
10. UT Southwestern study shows treating diabetes early, intensively is best strategy
11. Researchers report success in treating autism spectrum disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... ... build intelligent, connected applications, was named the best Sales Team of 2016 as ... announcement was made today by the Software & Information Industry Association (SIIA), the ...
(Date:11/30/2016)... ... November 30, 2016 , ... The Fertility ... designated as a Cigna Infertility Center of Excellence. The Cigna Center of Excellence ... “It’s an honor to be designated a Cigna Infertility Center of Excellence," said ...
(Date:11/30/2016)... ... 2016 , ... Standard Process, Inc. is proud to announce ... of the largest closely held companies headquartered in Wisconsin. This marks the company’s ... Process was awarded the Talent Award for providing outstanding employee benefits. , ...
(Date:11/30/2016)... ... November 30, 2016 , ... In ... been a focus of public policymakers and system stakeholders in many states. To ... its Medical Price Index for Workers’ Compensation, Eighth Edition (MPI-WC) . , ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... its orthopedic practice with the addition of new North Phoenix and Chandler locations. ... C. Lincoln North Mountain campus at 9327 North 3rd St, Suite 300 in ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... , Dec. 2, 2016  PipelineRx, a leading medication ... be offering demonstrations of its SaaS-based telepharmacy platform, ... Health-System Pharmacists 2016 Midyear Clinical Meeting and Exhibition, ... . With nearly 300 hospital clients nationally, the ... technology designed to dramatically improve pharmacy operations, enhance ...
(Date:12/2/2016)... On Thursday, December 1st 2016, ... research, development and innovation in the biopharmaceutical industry at ... in the presence of Sergey Tsyb, Vice Minister of ... , Natalia Sanina, First Vice Chairman of the ... of Roszdravnadzor, National Service of Control in Healthcare, Sergey ...
(Date:12/2/2016)... , Dec. 2, 2016  Eli Lilly and ... financial guidance for 2017 and provide updated financial guidance ... also conduct a conference call on that day with ... company,s financial guidance. The conference call will ... general public can access a live webcast of the ...
Breaking Medicine Technology: