Navigation Links
Treating drug resistant cancer through targeted inhibition of sphingosine kinase
Date:8/9/2012

Scientists at Tulane University School of Medicine, led by Dr. James Antoon and Dr. Barbara Beckman, have characterized two drugs targeting sphingosine kinase (SK), an enzyme involved in cancer growth and metastasis. New treatments specifically attacking cancer cells, but not normal ones, are critical in the fight against cancer. The results, which appear in the July 2012 issue of Experimental Biology and Medicine, demonstrate the role of SK in drug resistance and therapeutic potential of SK inhibitors.

"Sphingosine kinase is a relatively new molecular target," says Dr. Beckman "In this study, we show that overexpression of SK promotes resistance to first-line breast cancer therapies, such as tamoxifen. We further found that treatment with the sphingosine kinase inhibitors SKI-II and ABC294640 induced cell death and blocked drug-resistant tumor growth without similar effects in a model system representing relatively normal breast cells."

Molecular therapies, such as those targeting SK, have the potential to improve treatment response rates while simultaneously decreasing side effects. However, Dr. Antoon cautions that "while these results are promising, further study is needed to fully understand the benefits and risks associated with treating drug resistant cancer with these SK inhibitors."

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "Dr. Antoon, Dr. Beckman and colleagues present exciting results indicating the need for further study of inhibitors of sphingosine kinase as promising new cancer treatments".


'/>"/>
Contact: Dr. James Antoon
jantoon@tulane.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Study Suggests Treating Dyslexia Before Kids Learn to Read
2. New standards for treating traumatic shoulder injuries to improve patient care
3. Treating childhood obesity: A family affair
4. Unique physiology key to diagnosing and treating diabetes in Asian populations
5. Studies See Advances in Detecting, Treating Pancreatic Cancer
6. 1 size doesnt fit all when treating blood pressure in people with diabetes, VA/U-M study suggests
7. Nanomedicines promise fewer side effects in treating cancer
8. Mount Sinai researchers develop a multi-target approach to treating tumors
9. A non-antibiotic approach for treating urinary tract infections
10. UT Southwestern study shows treating diabetes early, intensively is best strategy
11. Researchers report success in treating autism spectrum disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 13, 2017 , ... ProVest Insurance Group, a family managed ... Raleigh regions, is organizing an extended charity drive to benefit the family of ... , After struggling since birth with several health challenges, T.J. was later diagnosed ...
(Date:10/13/2017)... , ... October 13, 2017 , ... While it’s often ... a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. , She ... in darkness or restricted lighting. As such, it eliminates the need to turn on ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading ... Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly ... CBD form that can be easily incorporated into liquid products, while reducing costs to ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
(Date:10/4/2017)... Oct. 4, 2017  According to the Centers for Disease Control and ... October . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the ... certain health insurance regulations. ... time to get a flu shot is by the end of October, ...
(Date:10/2/2017)...  AllianceRx Walgreens Prime, the combined central specialty pharmacy ... benefit manager Prime Therapeutics LLC (Prime), today officially began ... unveiling of new signage at its headquarters in ... a few other company-owned facilities across the country. This ... of whom will begin to see the AllianceRx Walgreens ...
Breaking Medicine Technology: