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Treating disease by the numbers
Date:9/20/2012

ique, fresh approach to research and treatment," Harris said. "We're talking about the ability to identify tailor-made treatments for individual patients for diseases that are multi-factorial and where it's difficult to isolate the path and physicality of the disease."

Harris and Guidoboni have worked together for the past 18 months on the project. Dr. Julia Arciero, assistant professor of mathematical sciences at IUPUI, is a principle investigator on the project as well with expertise in mathematical modeling of blood flow.

The preliminary findings have been published in the British Journal of Ophthalmology and the research currently is under review in the Journal of Mathematical Biosciences and Engineering and the European Journal of Ophthalmology. The NSF recognized their work on Aug. 30 with a three-year grant to continue their research.

The pair also presented their findings at the 2012 annual meeting of the Association for Research in Vision and Ophthalmology (ARVO). Harris suggested that, out of the 12,000 ARVO participants, their group might have been the only research group to include mathematicians, which speaks highly of the cross-disciplinary collaboration occurring regularly at IUPUI.

"We approached this as a pure math question, where you try to solve a certain problem with the data you have," said Guidoboni, co-director of the School of Science Institute for Mathematical Modeling and Computational Science (iM2CS) at IUPUI, a research center dedicated to using modeling methods to solve problems in medicine, the environment and computer science.

Guidoboni has expertise in applied mathematics. She also has a background in engineering, which she said helps her to approach medical research from a tactical standpoint where the data and feedback determine the model. She previously used modeling to better understand blood flow from the heart.

Harris said the potential impact has created quite a stir in the
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Contact: David Hosick
dhosick@iupui.edu
317-274-4585
Indiana University-Purdue University Indianapolis School of Science
Source:Eurekalert  

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