Navigation Links
Treating addiction by eliminating drug-associated memories
Date:4/23/2009

Philadelphia, PA, April 23, 2009 Addicts, even those who have been abstinent for long periods of time, are often still vulnerable to their own memories of prior drug use. For example, exposure to the same environment in which they commonly used drugs a contextual memory can increase their craving for the drug dramatically and can lead to relapse.

A new study in the April 15th issue of Biological Psychiatry (http://www.elsevier.com/locate/biopsychiat), published by Elsevier, has evaluated a novel compound that may ease the power of those memories.

"In this study, we found that after repeatedly giving cocaine injections to rats within a particular environment, the rats developed a strong preference for that environment over another environment where a placebo was given," explains M. Foster Olive, Ph.D., co-author and senior investigator. "Next, we treated the animals with an experimental drug called CDPPB, and found that it decreased the rats' preference for the cocaine-associated environment during subsequent tests."

This is a process called extinction learning, whereby the compound helps the brain to create new associations instead of retrieving the old associations, in this case between the cocaine and the environment. Dr. Olive also notes that this promising finding may aid the development of new therapeutic treatments that could be used in conjunction with exposure therapy, a technique used to desensitize individuals to stimuli that invoke negative responses or emotions.

John Krystal, M.D., Editor of Biological Psychiatry agrees and hopes that these findings can be expanded to other areas of work. "It will be interesting to see whether this approach extends to the treatment of cocaine abuse or other addictions. Further, it will be important to see whether mGluR5 agonists [like CDPPD] might play a role in the treatment of the extinction of other
'/>"/>

Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Treating sleep disorders in people with traumatic brain injury may not eliminate symptoms
2. Study reports success in treating a rare retinal disorder
3. Treating HIV earlier to decrease the risk of death
4. Cellular target may prove useful in treating deadly brain tumors
5. Treating Complicated Grief -- New NIMH Study Seeks 200 Older Adults Suffering from Unrelenting Symptoms of Complicated Grief for Participation in Non-Drug Clinical Trial
6. New Guidelines for Treating Heart Failure
7. Focus on treating malnutrition in cancer patients, researchers say
8. Less is more when it comes to treating high blood pressure
9. New Mexico Doctors Now Treating Brain and Prostate Cancer With RapidArc Radiotherapy Technology
10. Is telmisartan effective in treating non-alcoholic steatohepatitis?
11. Vitamin A signals offer clues to treating autoimmunity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... 2015 , ... Targeted therapies, made possible by a growing ... according to a newly published report. Surviving Mesothelioma has more on the findings ... The authors of the new paper focus on several types of targeted approaches ...
(Date:8/29/2015)... (PRWEB) , ... August 29, 2015 , ... Brands like ... with zero standard shipping costs. , “Before, a threshold of $49.00 was required ... select brands and items qualify for free standard shipping for customers regardless of the ...
(Date:8/29/2015)... Aliso Viejo, CA (PRWEB) , ... August 29, 2015 , ... ... Cut Pro X . Each preset contains 15 seconds of unique footage that users ... presets that rise, fall, zoom, attract and more. Users can customize color, brightness, scale, ...
(Date:8/29/2015)... ... August 29, 2015 , ... ... the localized area with stretching, soft tissue manipulation. Platelet rich plasma injections also ... shown through research to improve treatment outcomes. This localized treatment seems to ...
(Date:8/29/2015)... ... 29, 2015 , ... Vascular Health Sciences announced today that ... Arterosil HP, and that all claims and counterclaims have been irrevocably dismissed. , ... in the United States District Court for the Southern District of Texas for ...
Breaking Medicine News(10 mins):Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:TheBeautyPlace.com Discounts Shipping on Select Brands 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 3
... Human Settlement Programme, UN-Habitat and cola giant Coca Cola ... to safe drinking water and improved sanitation in India ... ,The project in India will be implemented in West ... non-government organisations (NGOs), the scheme aims at introducing rain ...
... and faculty of Indian origin add to the rich ethnic ... 430 km from here, where a gunman went on a ... of Indian origin. ,Founded in 1872, the Virginia ... called, has more than 25,000 students from as many as ...
... to sign an agreement with the International Vaccine Institute (IVI) ... has given its assent to the move. ,The ... country would now be able to play a role in ... ,The IVI is an International Organization established at the ...
... breast-feeding can negate the risks of breast cancer which are ... of 25. ,The findings of the study ... at the 2007 annual meeting of the American Association for ... may have a protective effect that negates the increased risk ...
... and appearing in today's advance online publication of Nature ... new tool for studying disease mechanisms and for identifying ... disease. ,Both studies were completed by researchers ... Estess Laboratory for Stem Cell Research, the world's first ...
... on arthritis, yet another study says. It neither prevents or ... studies. // ,"We do not have evidence to suggest ... says author Peter Jüni, head of clinical epidemiology and biostatistics ... paper comes a little more than a year after a ...
Cached Medicine News:Health News:Campaign for Safe Drinking Water in India, Nepal 2Health News:Indians Add to Rich Diversity of Virginia Tech 2Health News:Breastfeeding Keeps Breast Cancer At Bay- For Older Mothers 2Health News:Stem Cells Provide New Tool for Studying Disease and Identifying ALS Drugs 2Health News:Chondroitin may Not Have Any Beneficial Effect on Arthritis, New Study Says 2Health News:Chondroitin may Not Have Any Beneficial Effect on Arthritis, New Study Says 3
(Date:8/28/2015)... , Aug. 28, 2015 ... announced the addition of the "Investigation Report ... their offering. Originally discovered by Welfide ... Pharmaceutical Industries, Ltd) as an inflammatory drug, pranoprofen ... Pharmaceutical Co., Ltd under the trade name of ...
(Date:8/28/2015)... Utah , Aug. 28, 2015  Today, in ... Prevention,s (CDC) Contact Lens Health Week, 1-800 Contacts is ... has found that contact lens wearers who do not ... greatest risk for eye infections. Most ... their lenses, but a clean lens case is sometimes ...
(Date:8/28/2015)... Aug. 28, 2015 ... the addition of the "Investigation Report on ... offering. Developed by Pharmacia & Upjohn ... agonist which effectively reduces intraocular pressure. As the ... (under the trade name of Xalatan) entered ...
Breaking Medicine Technology:Investigation Report on China's Pranoprofen Market, 2010-2019 21-800 Contacts Shares Tips on How to Clean Lens Cases 2China Latanoprost Market Investigation Report 2015-2019 2
... FRANKLIN, Tenn., April 13, 2011 In the Journal ... March issue, a comparative research evaluation of five needleless I.V. ... InVision-Plus® (RYM-5001®) zero displacement connector best protected the intraluminal pathway ... The purpose of the study was to evaluate ...
... 12, 2011 Digital Assent founder ... this year,s "Top Up-and-Coming Entrepreneur" award, which will be presented ... from TiE Atlanta, an organization whose mission is to foster ... 2009 Ibbotson founded Digital Assent and launched its flagship product ...
Cached Medicine Technology:According to the Journal of Advanced Nursing, RyMed Technologies' InVision-Plus® Excels at Minimizing Bacterial Growth In Vitro 2Digital Assent CEO Selected as Finalist for 2011 Southeast Entrepreneur Awards 2
... Single Use linear stapler with LACTOMER™ ... Suture™ PREMIUM POLY CS™-57 disposable surgical ... of a temporary opening, such as ... section, or when transecting muscle tissue, ...
... Units With Titanium Staples for ... (Single Use Reloadable Stapler with ... Suture™ PREMIUM MULTIFIRE TA™ stapler ... pediatric and thoracic surgical procedures ...
... Single Use Loading Units for ... (Single Use Reloadable Staplers with ... Suture™ TA™ Reloadable staplers has ... and thoracic surgical procedures for ...
... linear stapler for resection, transection and anastomosis ... MULTIFIRE GIA™ 60 and 80 single use ... 80 single use loading units and the ... use surgical stapler with MULTIFIRE SGIA™ 60 ...
Medicine Products: