Navigation Links
Treating addiction by eliminating drug-associated memories
Date:4/23/2009

Philadelphia, PA, April 23, 2009 Addicts, even those who have been abstinent for long periods of time, are often still vulnerable to their own memories of prior drug use. For example, exposure to the same environment in which they commonly used drugs a contextual memory can increase their craving for the drug dramatically and can lead to relapse.

A new study in the April 15th issue of Biological Psychiatry (http://www.elsevier.com/locate/biopsychiat), published by Elsevier, has evaluated a novel compound that may ease the power of those memories.

"In this study, we found that after repeatedly giving cocaine injections to rats within a particular environment, the rats developed a strong preference for that environment over another environment where a placebo was given," explains M. Foster Olive, Ph.D., co-author and senior investigator. "Next, we treated the animals with an experimental drug called CDPPB, and found that it decreased the rats' preference for the cocaine-associated environment during subsequent tests."

This is a process called extinction learning, whereby the compound helps the brain to create new associations instead of retrieving the old associations, in this case between the cocaine and the environment. Dr. Olive also notes that this promising finding may aid the development of new therapeutic treatments that could be used in conjunction with exposure therapy, a technique used to desensitize individuals to stimuli that invoke negative responses or emotions.

John Krystal, M.D., Editor of Biological Psychiatry agrees and hopes that these findings can be expanded to other areas of work. "It will be interesting to see whether this approach extends to the treatment of cocaine abuse or other addictions. Further, it will be important to see whether mGluR5 agonists [like CDPPD] might play a role in the treatment of the extinction of other forms of maladaptive learning, such as the traumatic memories associated with posttraumatic stress disorder."


'/>"/>

Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related medicine news :

1. Treating sleep disorders in people with traumatic brain injury may not eliminate symptoms
2. Study reports success in treating a rare retinal disorder
3. Treating HIV earlier to decrease the risk of death
4. Cellular target may prove useful in treating deadly brain tumors
5. Treating Complicated Grief -- New NIMH Study Seeks 200 Older Adults Suffering from Unrelenting Symptoms of Complicated Grief for Participation in Non-Drug Clinical Trial
6. New Guidelines for Treating Heart Failure
7. Focus on treating malnutrition in cancer patients, researchers say
8. Less is more when it comes to treating high blood pressure
9. New Mexico Doctors Now Treating Brain and Prostate Cancer With RapidArc Radiotherapy Technology
10. Is telmisartan effective in treating non-alcoholic steatohepatitis?
11. Vitamin A signals offer clues to treating autoimmunity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... ... announced the official relaunch of its community and education hub for women considering ... mission is to create a safe and welcoming place for women to find ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... appointment of Jonathan (Jon) Otterstatter to its board of directors. Otterstatter ... proven leader in the development of technological innovations that lead to broad-based healthcare ...
(Date:5/24/2016)... ... May 24, 2016 , ... Bio-Logic Aqua® Research Water Life ... and a trainer for Ageless Grace ( http://www.agelessgrace.com ) to discuss healthier lifestyles, ... 16, 2016. , Formerly a Northwestern University Literature Professor, Kinst gravitated to her ...
(Date:5/24/2016)... ... May 24, 2016 , ... Controlling and maintaining the ... the launch of the Aquanta Water Heater Controller , a first-of-its-kind system that ... web-enabled device. As the Nest thermostat does for HVAC systems, Aquanta gives users ...
(Date:5/24/2016)... MA (PRWEB) , ... May 24, 2016 , ... ... Harvard Medical School, today announced a licensing relationship that will deliver a new ... This relationship will put the medical knowledge and expertise of Harvard Medical ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... UAE, May 23, 2016 Experts ... of Precision Medicine and the role of technology ...   The First International Conference of VPS-Penn Medicine ... distinguished patronage and presence of Sheikh Nahyan bin Mubarak Al ... in Precision Medicine, which helps provide personalized medicine and tailor-made ...
(Date:5/23/2016)... 23, 2016 The global  reprocessed ... billion by 2022, according to a new study by ... waste coupled with the lack of centralized support for ... drive the demand for reprocessed medical devices market. Additionally, ... to that of the original device is the high ...
(Date:5/22/2016)... DS Biopharma (DS) today ... compound DS102 in chronic obstructive pulmonary disease (COPD) ... patients. Recent DS preclinical data suggests ... and has bronchodilatory, anti-inflammatory and anti-fibrotic properties in ... will publish further detail on these findings later ...
Breaking Medicine Technology: