Navigation Links
Treating SSRI-resistant depression
Date:3/25/2008

Philadelphia, PA, March 25, 2008 When your antidepressant medication does not work, should you switch to a different medication from the same class or should you try an antidepressant medication that has a different mechanism of action" This is the question asked by researchers in a new report scheduled for publication in Biological Psychiatry on April 1st.

Papakostas and colleagues compared two strategies for treating symptoms of major depressive disorder that do not respond to treatment with a selective serotonin reuptake inhibitor (SSRI) antidepressant: either switching to a second SSRI or to a non-SSRI antidepressant. Some common SSRI antidepressants are fluoxetine (Prozac), citalopram (Celexa) and sertraline (Zoloft), while examples of a few common non-SSRI antidepressants are venlafaxine (Effexor) and buproprion (Wellbutrin, Zyban). The authors combined 4 studies comparing these two types of treatment strategies and performed a meta-analysis on the pooled data.

Dr. George I. Papakostas, corresponding author on this project, explains the results: Switching from a selective serotonin reuptake inhibitor to a drug with a different mechanism of action was found to be slightly more effective and slightly less-well tolerated than switching to a non-SSRI drug. Looking at the findings from a clinical perspective, the advantage in effectiveness means that 22 depressed people would need to be switched to treatment with a non-SSRI for one additional person to obtain relief from their symptoms.

John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, adds that this result may be related to the fact that while somewhat different, the medications evaluated in this report all acted on the monoamine systems of the brain. Because of the particular design of this study, the authors explain that subsequent studies examining whether differences in efficacy between these two treatments exist for specific subpopulations, symptoms, or symptom clusters are warranted. Dr. Krystal concludes that while this advantage could be important, there continues to be a pressing need to introduce new antidepressant medications that target novel brain mechanisms.


'/>"/>

Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Related medicine news :

1. Scientists identify new leads for treating parasitic worm disease
2. Link between treating osteoporosis with bisphosphonates and incidence of bone necrosis examined
3. Treating acne: 2 different acid peels are both effective, study finds
4. Early detection critical in treating pediatric thyroid cancer
5. Penn researchers discover new target for preventing and treating flu
6. Combo Therapy Shows Promise in Treating Brain Tumors
7. Combined radiation seed, chemotherapy wafer implants show promise in treating cancerous brain tumors
8. Adult Drug Effective in Treating Psoriasis in Children
9. How less can be more when treating some kidney cancers
10. Better access to cool caps improves outcomes, lowers cost of treating asphyxia in newborns
11. Treating Childhood Pneumonia at Home Could Save Lives in Developing Countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... ... ... In the United States alone, up to 36% of primary brain tumors ... brain tumors(3). Though most meningiomas are benign, metastatic brain tumors are known to grow ... options, the San Diego Gamma Knife Center offers a precision-medicine based solution ...
(Date:3/29/2017)... , ... March 30, 2017 , ... CHARM CITY RUN ... Run has announced that Mercy Medical Center will serve as the official title sponsor ... region. On Sunday, June 25, 2017, thousands of women will walk or run the ...
(Date:3/29/2017)... (PRWEB) , ... March 29, 2017 , ... ... hosting several educational opportunities for attending prescribers at the upcoming World Congress, in ... said, “A4M has always been recognized as the visionary leader in the training ...
(Date:3/29/2017)... ... March 29, 2017 , ... ... in Carnegie, OK, from Dr. Jamie Cameron, with or without a referral. ... to traditional orthodontic treatment. Depending on each patient’s case, treatment with the FASTBRACES ...
(Date:3/29/2017)... Chicago, Illinois (PRWEB) , ... March 29, 2017 ... ... Visio Stencils Device Library for documenting and diagramming network and data center assets ... , NetZoom subscribers can request new equipment shapes for free and download ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... 2017   Royal Philips (NYSE: PHG, ... and PathAI, a company that develops artificial intelligence ... to develop solutions that improve the precision and ... diseases. The partnership aims to build deep learning ... artificial intelligence to be applied to massive pathology ...
(Date:3/29/2017)... 29, 2017 NetworkNewsWire Editorial Coverage  ... There are ... in regulating marijuana, but economic arguments also favor its legalization. ... law enforcement costs. However, to legalize and regulate marijuana requires ... Inc. (OTC: SING) ( SING Profile ), American Cannabis Company ...
(Date:3/29/2017)... FinancialBuzz.com News Commentary  ... published in a research report by Grand View Research, Inc., projects that ... billion by 2025. The projection takes into consideration the continuous successful legalization ... open approach towards cannabis products around the world. In 2016, states - ... North Dakota , Ohio , and ...
Breaking Medicine Technology: