Navigation Links
Treating HIV earlier to decrease the risk of death
Date:4/14/2009

This release is available in French.

Montreal, April 14 2009 Begin treatment as early as possible: this general common sense rule seems to apply to most diseases except HIV-AIDS, which is only treated once a certain number of immune cells called "CD4+" cells have disappeared. The results of a North American study, which involved the team of Dr. Marina Klein of the Research Institute of the MUHC, run contrary to this consensus. The findings show that the risk of death in seropositive patients decreases by 69% to 94% if they start treatment earlier than officially recommended.

This study, which was recently published in the New England Journal of Medicine, could have considerable influence on medical practice.

Early treatment decreases the risk of death

In more precise terms, the risk of death decreases by 94% for patients who begin anti-HIV treatment when their CD4+ cell counts are above 500 cells per millilitre compared with those who start with a count below 500. Patients who begin treatment with a CD4+ cell count between 350 and 500 cells per millilitre see their risk of death reduced by 69% compared with those who begin at a lower count of 350.

"The official guidelines recommend starting anti-HIV treatment when the patient's CD4+ cell count is less than 350 cells per millilitre. This recommendation was formulated from data based on older medications that produced more side effects than current treatments," explained Dr. Klein. "Current therapies cause fewer side effects, are better tolerated and more effective so we can safely start treating patients earlier."

This study is the first of its scope to measure the risk of death based on the progress of infection at the start of treatment. The information was drawn from a number of databases in North America, including one managed by Dr. Klein at the Montreal Chest Institute,. In total, the researchers analyzed data from 17517 patients between 1996 and 2005.

and disease in general

"We have noticed that HIV treatments may decrease the impact of non-AIDS-related diseases, such as cardiovascular disease, liver disease, or cancer. This may be a reason why early treatment can decrease the risk of death overall," Dr. Klein continued. "We do not know the precise mechanisms behind this observation, but there are two plausible hypotheses. First, the medications seem to be more effective at supporting the immune system by acting earlier; second, they appear to prevent the HIV virus from replicating, which reduces inflammation."

Despite current treatment guidelines, there has been a growing trend to treat patients earlier and earlier once the virus is detected. This study could therefore reinforce this trend and possibly bring about an official change in the guidelines.


'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Related medicine news :

1. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
2. Is 4 agents decoction (Si Wu Tang) efficacious in treating primary dysmenorrhea?
3. Treating diabetes during pregnancy can break link to childhood obesity
4. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
5. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
6. Family-based treatment more effective than supportive psychotherapy in treating bulimia
7. Treating depression may improve recovery of heart rate variability following coronary syndromes
8. Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
9. Hospitals Improve Survival Rates While Treating Sicker Patients Thomson Healthcare Study Shows
10. Stem cells show promise for treating Huntingtons disease
11. Treating obstructive sleep apnea, preventing heart attacks and strokes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... 07, 2016 , ... Facial plastic surgeon, Dr. John D. Rachel of ... of proceeds to two local organizations: North Chicago Animal Control and Friends and Our ... a team of authorized and trained volunteers who support rescued animals held in the ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... Dallas, Texas, is condemning "scam operations" carried out by unethical locksmith companies and ... scam operations to a halt. According to Texas Premier Locksmith, these fraudulent locksmith ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... The ... the holidays and winter seasons. One major study analyzing heart attacks among 138,602 ... to August of a given year. We would all agree of course–no time of ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... 2016 BOC Business Brilliance Awards under the Best New Product Launch category. Gensuite’s ... achieved through user experience. , BOC Global Events & Training Group is a ...
(Date:12/7/2016)... ... December 07, 2016 , ... Maureen ... Program at Reproductive Medicine Associates of Connecticut (RMACT). McLaughlin brings nearly 20 years ... three acupuncturists to help patients realize their family building goals. Acupuncture helps ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... -- KEY FINDINGS Patient warming and ... loss of blood during surgeries, lowering the risks ... after surgeries, and decreasing risks of SSIs. The ... warming system, surface warming systems, and intravascular warming ... at hospitals thus, lowering the healthcare costs by ...
(Date:12/7/2016)... 7, 2016 Research and Markets has announced ... User - Global Forecast to 2021" report to their offering. ... , , ... by 2021, growing at a CAGR of 7.3% during the forecast period ... prevalence of cancer and rapidly increasing geriatric population across the globe are ...
(Date:12/7/2016)... Dec. 7, 2016 DelveInsight,s, "Janus ... provides in depth insights on the pipeline ... Janus Kinase 3 (JAK3) Inhibitors. The DelveInsight,s ... stages of development including Discovery, Pre-clinical, IND, ... Preregistration. Report covers the product clinical trials ...
Breaking Medicine Technology: