Navigation Links
Treating Childhood Leukemia With Fewer Side Effects
Date:9/10/2009

Dutch researchers skip radiation treatments, some chemo but add corticosteroid

THURSDAY, Sept. 10 (HealthDay News) -- Adding the corticosteroid dexamethasone to the treatment regimen of children with acute lymphoblastic leukemia improves survival rates and reduces the incidence of the cancer recurring, a new Dutch study shows.

Acute lymphoblastic leukemia (ALL), a cancer of the blood, is the most common childhood cancer and is highly treatable, according to background information in the study.

But the researchers say that many children with ALL are over-treated with cranial radiation and chemotherapy drugs that cause significant side effects and may not be necessary to cure them.

The study found that a dexamethasone-based treatment can improve the cancer cure rate and reduce the risk of relapse without radiation and routinely used chemotherapy drugs. The findings were published online Sept. 9 The Lancet Oncology.

Dexamethasone is sold under the brand name Decadron.

The study involved 859 youths, aged 1 to 18, with ALL. About 30 percent of them were considered to be at high risk for recurrence.

Participants not at high risk were given a basic three-drug induction (dexamethasone, vincristine and L-asparaginase) and medium-dose methotrexate. High-risk youths were given a four-drug induction (the same three drugs as the others got plus four doses of daunorubicin), consolidation with methotrexate and two intensification courses before maintenance, which was 109 weeks for all participants.

Triple intrathecal chemo was given 13 times in those not at high risk, 15 times in high-risk youths and 17 times in those with initial central nervous system involvement. No one was given cranial radiation.

Five-year, cancer-free survival for the high-risk group was 72 percent, the study found. Those not at high risk had an 84 percent survival rate. About 70 percent of all people newly diagnosed are not at high risk, according to the researchers.

The results for those not at high risk "were achieved with high cumulative doses of dexamethasone and vincristine, but without the use of anthracyclines, etoposide, cyclophosphamide or cranial irradiation, therefore minimizing the risk of side effects," they said in a news release from the journal. The survival rate for the high-risk group also was described as favorable.

More information

The U.S. National Cancer Institute has more on acute lymphoblastic leukemia.



-- Jennifer Thomas



SOURCE: The Lancet Oncology, news release, Sept. 9, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
2. Is 4 agents decoction (Si Wu Tang) efficacious in treating primary dysmenorrhea?
3. Treating diabetes during pregnancy can break link to childhood obesity
4. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
5. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
6. Family-based treatment more effective than supportive psychotherapy in treating bulimia
7. Treating depression may improve recovery of heart rate variability following coronary syndromes
8. Antidepressant shows early promise in treating agitation and psychotic symptoms of dementia
9. Hospitals Improve Survival Rates While Treating Sicker Patients Thomson Healthcare Study Shows
10. Stem cells show promise for treating Huntingtons disease
11. Treating obstructive sleep apnea, preventing heart attacks and strokes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Treating Childhood Leukemia With Fewer Side Effects
(Date:3/28/2017)... ORANGE, Calif. (PRWEB) , ... March 28, 2017 ... ... of its leading physicians, Paul Yost, will begin serving as new board chair ... earlier this month. Yost will serve the remainder of soon-to-be former chair Mark ...
(Date:3/28/2017)... ... March 28, 2017 , ... In its ongoing effort ... has recently developed and published an informational resource that addresses frequently asked questions. ... common inquiries the site’s team of third party administrator (TPA) contributors regularly receives ...
(Date:3/28/2017)... Santa Monica, CA (PRWEB) , ... March 28, ... ... expert, Dr. Carson Liu of SkyLex Advanced Surgical, Inc. is thrilled to offer ... newest gastric balloon procedure, and this procedure adds to SkyLex Advanced Surgical’s ...
(Date:3/28/2017)... ... ... common and unwelcomed occurrence in people of all ages, genders and ethnicities. Dermatologist Dr. Sonoa ... dealing with excess skin oil. “Oily skin is a challenge to many of my patients. ... oily shine while keeping the skin fresh and clean,” says Dr. Au. , What causes ...
(Date:3/27/2017)... ... March 27, 2017 , ... New patients who have ... sleep apnea treatment, with or without a referral. Sleep apnea is often left untreated ... daytime sleepiness, morning headaches and chronic snoring. , Dr. Braasch seeks to raise ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... AVIV, Israel , March 27, 2017 ... on oncology and immunology, announced today that AGI-134, an immunotherapy ... announced acquisition of Agalimmune Ltd., will be featured at the ... in Washington, DC to be ... ...
(Date:3/27/2017)... March 27, 2017   Pulmatrix, Inc . (NASDAQ: PULM), ... address serious pulmonary diseases, today announced that it has added ... fibrosis and asthma to its Scientific Advisory Board . ... Richard B. Moss , MD, former chief of the ... Cystic Fibrosis Center at Stanford University, and ...
(Date:3/27/2017)... , March 27, 2017  BERG, a ... data-driven, biological research approach, today announced that ... the discovery of new data using a ... brown fat metabolism. Joslin Diabetes Center led ... Biology® platform for analysis of samples.  The ...
Breaking Medicine Technology: