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Traumatic brain injury: NIH-funded researchers will assess biomarkers for diagnosis and treatment
Date:8/3/2011

after TBI. Although preliminary studies suggest that serum levels of four biomarkers may more accurately predict the extent of injury than the commonly used Glasgow Coma Scale and CT scan, these have not yet been established as a reliable clinical tool.

Using the large patient group in the ProTECT III trial, the researchers hope to validate promising TBI biomarkers as predictors of clinical outcome and also evaluate the relationship between progesterone treatment, biomarker levels and outcome.

In an earlier pilot clinical trial several years ago, Emory researchers concluded that giving progesterone to trauma victims shortly following brain injury is safe and may reduce the risk of death and long-term disability. This led to the multicenter Phase III ProTECT trial currently underway.

"This new biomarker study should allow us to refine risk assessment for patients with moderate and severe TBI and evaluate the relationships between progesterone levels, serum biomarkers of structural injury in the brain, and clinical outcome," says Frankel. "This will not only help us assess the effectiveness of using progesterone to treat TBI, but will lead us to a more tailored approach for treatment of these patients."

Frankel also has been working as the principal investigator of another NIH-funded study in the innovative field of biomarkers, gathering data from the blood of stroke patients to determine who is at highest risk for recurrent stroke.


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Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

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