Navigation Links
Trastuzumab raises risk of heart problems in the elderly with history of heart disease or diabetes
Date:8/9/2011

221.10.254.64

The first study to investigate the effect of the breast cancer drug trastuzumab (Herceptin) on heart and vascular function in elderly patients has found that it increases the risk of heart problems, particularly in women with a history of heart disease, diabetes or both.

Authors of the study, published in the cancer journal, Annals of Oncology today [1], looked at records for 45 women aged between 70 and 92 who had been treated with trastuzumab since 2005 and found that 26.7% (12) of the patients developed heart problems caused by the drug a slightly higher rate than seen in earlier, clinical trials in younger, healthier women. Thirty-three percent of the women with a history of heart disease developed either asymptomatic and symptomatic heart problems as a result of taking trastuzumab, compared to only 9.1% of women without such a history, and 33.3% of women with diabetes developed problems compared to only 6.1% without the condition. When trastuzumab treatment was stopped, all but one of the women recovered fully and five of them were able to re-start the treatment.

Trastuzumab is the current standard of care for women diagnosed with the type of breast cancer that expresses the protein HER2 on the surface of the cancer cells (HER2 positive breast cancer). Although breast cancer is most common in elderly women, clinical trials of trastuzumab have been carried out in younger women, "ideal patients", who have few if any other health-related issues.

Dr Csar Serrano, who carried out the research while working as a clinical fellow at the Department of Medical Oncology Breast Cancer Centre at the Vall d'Hebron University Hospital in Barcelona, Spain, said: "This is the first study specifically to assess trastuzumab-related cardiac toxicity and the cardiovascular factors that are associated with an increased risk in a selected population of elderly breast cancer patients.

"Tra
'/>"/>

Contact: Emma Mason
wordmason@mac.com
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Smoking After Heart Attack Raises Risk of Dying
2. Localized reactive badger culling raises bovine tuberculosis risk, new analysis confirms
3. Too Much TV Raises Risk of Diabetes, Heart Disease and Death
4. Good Sleep Raises Quality of Life, Lowers Depression
5. Obesity raises breast cancer survivors risk of dying of the cancer
6. Smoking Raises Odds for Cancer in Women Already at High Risk
7. Rise of for-profit hospice industry raises troubling questions, new study says
8. Hospital Infection Raises Death Risk for Bowel Patients
9. NIDA raises the curtain on addiction
10. Large weight gain raises risk for recurrence among breast cancer survivors
11. Nicotine Raises Blood Sugar Levels in Lab
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... (PRWEB) January 22, 2015 Blue Cross and ... Minnesotans who exemplify what it means to “Live Fearless.” ... for people to share their stories about how they or ... simply inspired others by living in the moment. By telling ...
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 The ... ) in the U.S. District Court, Southern District of West ... Bard, Inc. in that proceeding’s first bellwether trial. In an ... for a new trial after finding that C.R. Bard had ...
(Date:1/22/2015)... 22, 2015 A new white paper ... and person-centeredness in the long-term care environment as well ... the continuum. The paper, “The Power of Person-Centeredness in ... and practices of the patient, resident and family experience ...
(Date:1/22/2015)... has released a new blog post explaining the main features ... , Auto insurance quotes help many drivers find the best ... call an agent or visit an agency for price information. ... http://autocarinsurancebest.com/ . , Every business who relies heavily on ...
(Date:1/22/2015)... Carinsurancesavings.biz has released a new blog post presenting the basic ... , Purchasing an accidental death and dismemberment rider for a ... rider provides benefits if the insured dies in an accident. ... of life insurance. , AD&D is not expensive and ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2
... Is Not Safe for Everyone , Not all ... epirubicin. New models can help physicians calculate the epirubicin ... for individual patients. , Oncologists frequently use anthracyclines, including ... the drugs cause lasting heart problems in a substantial ...
... percent sequentially - Q2 GAAP net profit of ... - Case shipments of 54,870 increase 6.0 percent sequentially ... CLARA, Calif., July 29 Align,Technology, Inc. (Nasdaq: ALGN ) ... June 30, 2008., Total net revenues for the second quarter ...
... ceramic implantable components surpasses projected ... ... Medical Werks, a manufacturer of,high-quality ceramic solutions for the medical device ... millionth ceramic,implantable component based on unit shipments to the orthopaedic,brachytherapy and ...
... Benjamin, MD, FACP, FACEP (E), Executive,Director, American Public ... American Public,Health Association strongly urges U.S. House members ... give the Food and Drug Administration (FDA),the authority ... is responsible for more than 400,000 deaths each,year ...
... matted protein, researchers say , , TUESDAY, July 29 (HealthDay News) ... "tangles" in the brain cells of people with Alzheimer,s disease ... are necessary to confirm whether the medication is as effective ... to be given as part of a cocktail of treatments. ...
... New Jersey Health Care Quality Institute Announces Results of Milken ... Institute Study Future Costs Can ... ... a groundbreaking study,released by the Milken Institute, the annual economic impact on New,Jersey,s economy of ...
Cached Medicine News:Health News:Also in the July 29 JNCI 2Health News:Also in the July 29 JNCI 3Health News:Also in the July 29 JNCI 4Health News:Also in the July 29 JNCI 5Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 2Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 3Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 4Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 5Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 6Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 7Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 8Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 9Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 10Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 11Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 12Health News:Align Technology Announces Second Quarter Fiscal 2008 Results 13Health News:C5 Medical Werks Reaches Million Mark in Components Shipped 2Health News:'De-Tangling' Alzheimer's Drug Shows Promise 2Health News:'De-Tangling' Alzheimer's Drug Shows Promise 3Health News:'De-Tangling' Alzheimer's Drug Shows Promise 4Health News:Annual Economic Impact of Chronic Disease on New Jersey Economy Is $39 Billion 2Health News:Annual Economic Impact of Chronic Disease on New Jersey Economy Is $39 Billion 3Health News:Annual Economic Impact of Chronic Disease on New Jersey Economy Is $39 Billion 4
(Date:1/23/2015)...  Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT), announced that the number ... lead compound, LB‑100, is being conducted, has been expanded from ... , M.D., the founder and President of Lixte, said that, ... single site. Accrual of patients, however, was slower than projected. ...
(Date:1/23/2015)... Jan. 23, 2015   Leatt Corporation  (OTCQB: LEAT), a ... for all forms of sports, including extreme motor sports, ... announced today that the UISP Lega Motociclismo Lombardia, an ... riders to wear a neck brace during its racing ...
(Date:1/23/2015)... , Jan. 23, 2015  Mallinckrodt plc (NYSE: ... Directors has approved a share repurchase program. The open-ended ... million of Mallinckrodt plc ordinary shares. ... remain top priorities as we continue to pursue a ...
Breaking Medicine Technology:Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4
... Calif., Dec. 17 PEAK Surgical, Inc., a ... dissection system based on a,proprietary technology, announced today ... granted the company 510(k) clearance to market its,PEAK(R) ... tissue during,plastic and reconstructive, ENT (ear, nose and ...
... Calif., Dec. 17 Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: ... independent,Data Safety Monitoring Board (DSMB) has determined that ... of acute ischemic stroke are unlikely,to show benefit. ... enrollment in,the trials. NTI will obtain and analyze ...
Cached Medicine Technology:PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in Expanded Indications 2PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in Expanded Indications 3PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in Expanded Indications 4Neurobiological Technologies Announces Viprinex(TM) Does Not Pass Interim Futility Analysis 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... advanced nutritional formulation that provides powerful ... health. MacularProtect Complete-S, based on the ... research, delivers a diverse array of ... FloraGLO® lutein and other important nutrients. ...
Medicine Products: