Navigation Links
Trastuzumab raises risk of heart problems in the elderly with history of heart disease or diabetes
Date:8/9/2011

221.10.254.64

The first study to investigate the effect of the breast cancer drug trastuzumab (Herceptin) on heart and vascular function in elderly patients has found that it increases the risk of heart problems, particularly in women with a history of heart disease, diabetes or both.

Authors of the study, published in the cancer journal, Annals of Oncology today [1], looked at records for 45 women aged between 70 and 92 who had been treated with trastuzumab since 2005 and found that 26.7% (12) of the patients developed heart problems caused by the drug a slightly higher rate than seen in earlier, clinical trials in younger, healthier women. Thirty-three percent of the women with a history of heart disease developed either asymptomatic and symptomatic heart problems as a result of taking trastuzumab, compared to only 9.1% of women without such a history, and 33.3% of women with diabetes developed problems compared to only 6.1% without the condition. When trastuzumab treatment was stopped, all but one of the women recovered fully and five of them were able to re-start the treatment.

Trastuzumab is the current standard of care for women diagnosed with the type of breast cancer that expresses the protein HER2 on the surface of the cancer cells (HER2 positive breast cancer). Although breast cancer is most common in elderly women, clinical trials of trastuzumab have been carried out in younger women, "ideal patients", who have few if any other health-related issues.

Dr Csar Serrano, who carried out the research while working as a clinical fellow at the Department of Medical Oncology Breast Cancer Centre at the Vall d'Hebron University Hospital in Barcelona, Spain, said: "This is the first study specifically to assess trastuzumab-related cardiac toxicity and the cardiovascular factors that are associated with an increased risk in a selected population of elderly breast cancer patients.

"Tra
'/>"/>

Contact: Emma Mason
wordmason@mac.com
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Smoking After Heart Attack Raises Risk of Dying
2. Localized reactive badger culling raises bovine tuberculosis risk, new analysis confirms
3. Too Much TV Raises Risk of Diabetes, Heart Disease and Death
4. Good Sleep Raises Quality of Life, Lowers Depression
5. Obesity raises breast cancer survivors risk of dying of the cancer
6. Smoking Raises Odds for Cancer in Women Already at High Risk
7. Rise of for-profit hospice industry raises troubling questions, new study says
8. Hospital Infection Raises Death Risk for Bowel Patients
9. NIDA raises the curtain on addiction
10. Large weight gain raises risk for recurrence among breast cancer survivors
11. Nicotine Raises Blood Sugar Levels in Lab
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... ... Since 1978, the number of black males applying to and attending medical school ... AAMC (Association of American Medical Colleges). , Despite an overall increase in the ... black male applicants to medical school dropped to 1,337 in 2014 (from 1,410 in ...
(Date:8/3/2015)... ... ... The Workgroup for Electronic Data Interchange ( WEDI ), the nation’s leading nonprofit ... announced the release of its findings from its June 2015 ICD-10 Industry Readiness Survey. ... survey results and recommendations , strongly encouraging the department to continue to ...
(Date:8/3/2015)... ... August 03, 2015 , ... According to an opinion piece published July 28 by ... to one pound of weight loss may not be accurate. While this system may work ... pound of fat varies – based both on the individual and at what point that ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... Bayer has ... and Yasmin related claims in which a claimant alleged to have suffered an arterial ... to the birth control pills, Yaz, Yasmin and Ocella, has been ongoing for well-over ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... MarketingProfs Bright Bulb B2B Awards. , The MarketingProfs Bright Bulb B2B Awards celebrate ... BESLER Consulting's campaign for the launch of their Readmissions Analytics product was selected ...
Breaking Medicine News(10 mins):Health News:New Publication Focuses on the Decline of Black Males in Medicine 2Health News:New Publication Focuses on the Decline of Black Males in Medicine 3Health News:New Publication Focuses on the Decline of Black Males in Medicine 4Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 2Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 3Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 4Health News:Article Dispelling Weight Loss Myth Correctly Emphasizes the Complicated and Difficult Nature of Weight Loss, Says Dr. Michael Feiz 2Health News:Bayer Agrees To Settle Yaz Aterial Blood Clot Lawsuits 2
... Ciara, Kelly Rowland, Common, Romeo and Lyfe ... ... that,their award-winning national HIV/AIDS public information campaign with the,Kaiser Family Foundation, Rap-It-Up ... KNOW BOUT THAT? RAP-IT-UP SEX,QUIZ" slated to premiere on Monday, November 5 ...
... Hundreds of Local Kidney Patients Requiring,Dialysis; More ... Disease, EL SEGUNDO, Calif. Nov. 2 ... of dialysis services in the,United States, announced today ... the Fargo-Moorhead area -- increasing the number of,outpatient ...
... flexibility and cost-control, SOUTH PORTLAND, Maine, Nov. ... health insurance options of much larger businesses. Anthem,Blue ... portfolio of eleven,insurance plans for small businesses (50 ... insurance products provide more health insurance,choices than have ...
... to other groups, study says , FRIDAY, Nov. 2 ... for post-traumatic stress disorder (PTSD) shows promise, according to ... The American Journal of Psychiatry . , The study ... to an Internet-based, eight-week program of self-management CBT no ...
... 2 RHEI Pharmaceuticals, Inc., a,fully integrated specialty ... China market, will be presenting, at the,Acumen BioFin ... Monday,November 5, 2007 at 2:20 p.m., eastern. ... any,company wishing to gain access to the fastest ...
... Mammography Van Features ... NovationDR Digital System, MALVERN, Pa., Nov. 2 ... digital mammography,system in the U.S. The MAMMOMAT(R) NovationDR, a ... Nevada Cancer Institute,s,(NVCI) new Hope Coach, a mobile digital ...
Cached Medicine News:Health News:BET Networks Special 'What U Know Bout That? Rap-It-Up Sex Quiz' HIV/AIDS To Premiere On Monday, November 5 At 7:30 P.M. ET/PT 2Health News:BET Networks Special 'What U Know Bout That? Rap-It-Up Sex Quiz' HIV/AIDS To Premiere On Monday, November 5 At 7:30 P.M. ET/PT 3Health News:BET Networks Special 'What U Know Bout That? Rap-It-Up Sex Quiz' HIV/AIDS To Premiere On Monday, November 5 At 7:30 P.M. ET/PT 4Health News:DaVita to Open First Independent Dialysis Clinic in Fargo-Moorhead 2Health News:Anthem Introduces New Insurance Options for Small Business 2Health News:Web-Based Stress Therapy Shows Promise for Vets 2Health News:Siemens Rolls Out Its First Mobile Digital Mammography System in the U.S. 2Health News:Siemens Rolls Out Its First Mobile Digital Mammography System in the U.S. 3
(Date:8/3/2015)... SAN FRANCISCO , Aug. 3, 2015  Sage ... generation of portable laboratory-quality cannabis potency measurement systems, announced ... PAC Bay Area Cruise Fundraiser. A limited number of ... the festivities and help a great cause while enjoying ... a scenic cruise around the San Francisco Bay at ...
(Date:8/3/2015)... -- Depomed, Inc. (NASDAQ: DEPO ) ("Depomed" or the ... HZNP ) ("Horizon") announcement that it intends to request ... record date to determine the shareholders eligible to request ... will review the request when it is received. Provided ... information required under Depomed,s bylaws, the Depomed Board will, ...
(Date:8/3/2015)... NEW YORK , August 3, 2015 /PRNewswire/ ... report published by Persistence Market Research "Global Market ... to Witness Highest Growth by 2022", ... at US$15 Bn by the end of 2015 and ... 6.8% from 2015 to 2022, to account for ...
Breaking Medicine Technology:Sage Analytics Sponsors California Cannabis Industry Association Bay Area Cruise FUNdraiser 2Depomed Comments on Horizon Pharma Announcement 2Depomed Comments on Horizon Pharma Announcement 3Depomed Comments on Horizon Pharma Announcement 4Depomed Comments on Horizon Pharma Announcement 5Depomed Comments on Horizon Pharma Announcement 6Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 2Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 3Global Physiotherapy Equipment Market Will Reach US$ 23.7 Billion by 2022: Persistence Market Research 4
... PRO-DEX, INC. (Nasdaq: PDEX ) invites investors and ... fiscal 2012 first quarter financial results. (Logo:   ... be broadcast live over the internet on Wednesday, November 9, ... and may be accessed by visiting the Company,s website at ...
... VIEW, Calif., Nov. 3, 2011 VIVUS, Inc. (NASDAQ: ... were published in Obesity, the peer-reviewed journal of The ... the investigational drug Qnexa in 1,267 severely obese (BMI >/= 35 ... addition to average weight loss of 14.4% of initial body weight ...
Cached Medicine Technology:Pro-Dex, Inc. Announces Fiscal 2012 First Quarter Financial Results Conference Call and Webcast 2Qnexa® Phase 3 Data Published In Obesity Show 14.4% Average Weight Loss In Severely Obese Patients Completing One Year Of Treatment 2Qnexa® Phase 3 Data Published In Obesity Show 14.4% Average Weight Loss In Severely Obese Patients Completing One Year Of Treatment 3Qnexa® Phase 3 Data Published In Obesity Show 14.4% Average Weight Loss In Severely Obese Patients Completing One Year Of Treatment 4Qnexa® Phase 3 Data Published In Obesity Show 14.4% Average Weight Loss In Severely Obese Patients Completing One Year Of Treatment 5Qnexa® Phase 3 Data Published In Obesity Show 14.4% Average Weight Loss In Severely Obese Patients Completing One Year Of Treatment 6
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: