Navigation Links
Trapping prostate cancer cells to keep them from spreading provides hope

Tampa, Fla. (March 10, 2011) When prostate cancer stem cells (CSCs) were enclosed in self-assembling nanomaterials made of peptides (SAP), the SAP stopped cancer stem cell colony formation and also stopped the division of cancer cells in laboratory cultures (in vitro). According to the international team of researchers who built and tested the nano-sized traps and published their results in a recent issue of Cell Transplantation (20:1), which is freely available on-line at , the cancer cells grew and multiplied after they were "liberated" from their SAP prisons.

In their article, the researchers suggested that CSCs may be the origin of prostate tumor metastasis, making them an "ideal target" for inhibiting disease metastasis. The group's previous work in building nanomaterials showed that by using SAPs they were able to control the proliferation, elongation and maturation of cells in vitro.

"In this study, we have shown that prostate CSCs can be placed into stasis for an extended period of time without causing them to differentiate," said study corresponding author Dr. Rutledge Ellis-Behnke of the Heidelberg University-based Nanomedicine Translational Think Tank. "If cells are prevented from migrating away from the treatment, they could be subjected to additional targeting."

For the researchers, the isolation of cancer cells with stem-like characteristics "provides solid evidence" that CSCs may exist within the tumor. Additionally, CSCs may account for some treatment failures when treatments are unable to successfully target cancer stem cells, which may be resistant to chemotherapy drugs. Too, CSCs have been found to be more invasive than non-CSCs. The authors speculated that by injecting the material directly into the tumor, it may be possible to stop the spread of metastatic cells.

The research team also suggested that trapping CSCs in the nanomaterial would allow for loading of the SAP with chemotherapy agents, thus offering an increased effectiveness of a localized treatment when targeted cancer cells were unable to 'escape' their chemical enemies. This approach for treating metastatic hormone refractory prostate cancer (HRPC) - a cancer for which all current therapies fail - may offer hope as a successful treatment.

"The goal of cancer therapy is to reduce the ability of cancer cells to divide and migrate," said Dr. Ellis-Behnke. "Accordingly, we have shown that SAP can completely inhibit a prostate CSC from self-renewal while preserving its viability and stem cell properties."

Their study concluded that SAP may be "an effective nanomaterial for inhibiting cancer progression and metastasis."

"The ability to sequester cancer stem cells in SAP to prevent the spread of a prostate cancer is a big step toward finding effective treatments for cancer," Shinn-Zong Lin, professor of neurosurgery at China University Medical Hospital, Taiwan and chair of the Pan Pacific Symposium on Stem Cell Research where this work was first presented. "It will be of considerable interest to se how this technology develops."


Contact: David Eve
Cell Transplantation Center of Excellence for Aging and Brain Repair

Related medicine news :

1. New twist on potential malaria drug target acts by trapping parasites in cells
2. Rapid Rise in PSA Levels a Poor Predictor of Prostate Cancer: Study
3. Newer Drug May Help Prevent Fracture in Men With Prostate Cancer
4. PSA velocity screening for prostate cancer may lead to unnecessary biopsies
5. Change in PSA level does not predict prostate cancer
6. PSA Screening for Prostate Cancer Dips in Large U.S. Health Network
7. HJF signs distribution agreement for antibody to evaluate prostate cancer
8. PSA Test Cut-off Could Signal Low-Risk Prostate Cancer
9. Research presented at 2011 GU Cancers Symposium highlights advances in treatment of prostate cancer
10. Could Hair Loss at 20 Signal Higher Prostate Cancer Risk?
11. Losing hair at 20 is linked to increased risk of prostate cancer in later life
Post Your Comments:
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... ... ... closing of Bruton Memorial Library on June 21 due to a possible lice infestation, as ... of head lice: the parasite’s ability to live away from a human host, and to ... one in the event that lice have simply gotten out of control. , As lice ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from reveals that behind the ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
Breaking Medicine Technology: