Navigation Links
Transplanted human placenta-derived stem cells show therapeutic potential in stroke models
Date:2/1/2011

Human amniotic epithelial cells, stem cells derived from human placenta left over from live births and generally discarded, proliferated and differentiated when they interacted with one kind of melatonin receptor, MT1. This potentially therapeutic response occurred when the stem cells were transplanted into laboratory test tube and animal models of stroke. The same cells did not perform similarly when interacting with melatonin receptor MT2.

Researchers from the University of South Florida's Department of Neurosurgery and Brain Repair, and co-researchers in Brescia, Italy, concluded that the placenta-derived stem cells and their interaction with MT1 promoted functional recovery in the laboratory mice with modeled stroke.

Their study is published in the current issue of the Journal of Pineal Research.

"Along with increasing cell proliferation and survival rate, MT1 also enhanced the differentiation of placenta-derived stem cells into neuronal cells," said the study's lead author, Yuji Kaneko, PhD, a researcher with the USF Center of Excellence for Aging and Brain Repair. "Targeting the MT1 receptor could be beneficial as MT1 appears to enhance cell proliferation."

According to Dr. Kaneko, placenta-derived stem cells are pluripotent - able to differentiate into many types of cells - and current research is geared toward investigating their ability to differentiate into neuronal cells for the purpose of brain repair. Dr. Kaneko and colleagues examined how stem cells "express" specific melatonin receptors. MT1 is one of two kinds of melatonin found in humans, the primary hormone secreted by the pineal gland. The MT1 receptor is a membrane protein located in specific regions of the brain.

Although their research focused on models of stroke, the researchers concluded that human amniotic epithelial cell-melatonin treatment could also be useful in treating oxidative stress. Additionally, and consistent with past studies, they found high levels of vascular endothelial growth factor acting in concert with melatonin. They suggest that MT1's "solicitation' of this growth factor might have contributed to how amniotic epithelial cells and MT1 worked together to produce a neuroprotective effect while the placenta-derived stem cells and MT2 did not.

"This 'cross-talk' between melatonin and stem cells is an under explored research area," Dr. Kaneko said.

Their results, said Dr. Kaneko, advance the concept of melatonin receptor technology in stem cell therapy by which stem cells can be switched on with melatonin treatment, or switched off by withholding melatonin.

"This melatonin receptor technology can facilitate the regulation of stem cell growth and differentiation as well as the stimulation of the cell's growth factor secretory capacity," he concluded.


'/>"/>

Contact: Randolph Fillmore
rfillmor@health.usf.edu
813-974-0868
University of South Florida (USF Health)
Source:Eurekalert

Related medicine news :

1. Immune system helps transplanted stem cells navigate in central nervous system
2. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
3. New Period of Brain ‘Plasticity' Created with Transplanted Embryonic Cells
4. Cancer-targeting investigational nanoparticle receives FDA IND approval for first-in-human trial
5. Wild Hogs in Texas Pose Infection Risk to Humans
6. Researchers reveal function of novel molecule that underlies human deafness
7. Illegal use of human growth hormone common among young male weightlifters
8. Like humans, amoebae pack a lunch before they travel
9. Speaker series highlights the role of animals in human culture
10. Obesity in horses could be as high as in humans
11. Study details how protein made by HPV teams up on and thwarts protective human protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... Viejo, California (PRWEB) , ... June 25, 2016 , ... ... to fit their specific project," said Christina Austin - CEO of Pixel Film Studios. ... fully customizable and all within Final Cut Pro X . Simply select a ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
Breaking Medicine Technology: