Navigation Links
Transplantation: 'molecular miscegenation' blurs the boundary between self and non-self
Date:10/30/2008

A new discovery by London biologists may yield new ways of handling the problem of transplant rejection. In a research article published in the November 2008 print issue of The FASEB Journal (http://www.fasebj.org), the scientists confirm the two-way transfer of a molecule (called "MHC") that instructs the immune system to tell "self" from "non-self." By disrupting the transfer of this molecule, newly transplanted organs should become "invisible" to the host's immune system. Such an advance would be considered a major medical breakthrough because current methods of preventing organ rejection involve weakening the host's immune system, which can lead to life-threatening infections.

"The medical potential of this finding is enormous," says Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "Understanding molecular miscegenation should not only make transplantation more widespread and effective, but also shed light on how microbes disrupt our body's immune apparatus for distinguishing self from non-self."

The researchers made this discovery when they transplanted kidneys or hearts from one set of mice into another, with each set of mice having a different version of the molecule being studied. The researchers then conducted tests to see if the molecules were transferred. In the recipient mice, the donated kidneys or hearts and the host tissue expressed both types of molecules. This is the first time that this transfer has been shown to happen in a living system.

Wilson Wong, senior researcher on the study from King's College London, states that although the findings are tantalizing, they represent only a very primitive understanding of this phenomenon. Nevertheless, he hopes "that this study will lead to a better understanding of the immune system to benefit the development of new therapies in areas related to transplantation."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... 21, 2014 Hundreds of Risperdal ... in Pennsylvania’s Philadelphia Court of Common Pleas, Bernstein ... proceeding’s next monthly meeting has been scheduled for ... , “Our Firm is representing a number of ... litigation. We are pleased with its continued progress,” ...
(Date:9/21/2014)... 2014 (HealthDay News) -- Young women starting college understand ... foods they should eat. But they aren,t confident they ... to a new study. The study involved ... Illinois,s Peer Education Exercising and Eating Right program. The ... choose to eat if they were very busy with ...
(Date:9/21/2014)... 2014 Discount-Dress.com, a company ... recently announced its decision to implement a new shopping ... for ladies across the world. Furthermore, the company has ... ladies. , The new items come in fashionable ... prices, up to 56 percent off. "We are happy ...
(Date:9/21/2014)... Dallas, TX (PRWEB) September 21, 2014 ... and Chinese Fenofibrate (CAS 49562-28-9) Industry, 2009-2019 ... on Global and Chinese Fenofibrate (CAS 49562-28-9) ... information of Fenofibrate (CAS 49562-28-9) including its ... explores global and China’s top manufacturers of ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 High in ... teams of disabled and able-bodied athletes rafted the Colorado ... a ropes course in pursuit of outdoor adventure. At ... national non-profit World T.E.A.M. Sports, disabilities proved to be ... successfully completed the three stage event. , Each participating ...
Breaking Medicine News(10 mins):Health News:Risperdal Lawsuits Move Forward in Pennsylvania Litigation, As Court Schedules October Meeting, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Move Forward in Pennsylvania Litigation, As Court Schedules October Meeting, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Move Forward in Pennsylvania Litigation, As Court Schedules October Meeting, Bernstein Liebhard LLP Reports 4Health News: College Women Can Use Food Strategies, Study Finds 2Health News:Discount-Dress.com Implements A New Shopping Cart Software And Provides New Beach Wedding Dresses 2Health News:Fenofibrate Industry Global and Chinese Analysis for 2014-2019 Now Available at LifeScienceIndustryResearch.com 2Health News:Fenofibrate Industry Global and Chinese Analysis for 2014-2019 Now Available at LifeScienceIndustryResearch.com 3Health News:Fenofibrate Industry Global and Chinese Analysis for 2014-2019 Now Available at LifeScienceIndustryResearch.com 4Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 2Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 3
... LLC has joined the effort to help relieve ... of Cyclone Nargis. Special donation kiosks,have been developed ... the,virtual world of Second Life, with coordination being ... island,( http://slurl.com/secondlife/Simuality/106/83/41 )., In addition, links to ...
... Coalition for Iraq and Afghanistan Veterans Gather in Virginia ... Organizations, CHANTILLY, Va., May 9 As the ... death toll climbs above 4,000 and,casualty numbers approach the ... organizations on the homefront have organized to help,bereaved families ...
... disease-resistant gene wards off fusarium wilt on leaves , , ... to helping tomatoes fight a fungus that causes wilt ... there,s an ongoing battle against the ability of plant ... system, according to background information in the study. One ...
... demands reap mental benefits regardless of age or ... News) -- Having an intellectually demanding job that ... abilities during retirement, regardless of intelligence, education level ... suggests. , "Our society is expected to live ...
... wanted minimally invasive procedure more often, despite drawbacks , , ... be trumping science when it comes to treatments for ... patients are getting a newer, minimally invasive surgery, because ... though there is little data on actual differences in ...
... From Bush Administration,s $770 Million Cut to,Medicare-Financed Nursing Home ... the,American Health Care Association (AHCA) and Alliance for Quality ... release and comment on a,new study from The Lewin ... from the Bush Administration,s recently-announced cut of,$770 million to ...
Cached Medicine News:Health News:Leading Veterans Service Organizations Meet Near Washington May 13-15, 2008 2Health News:Leading Veterans Service Organizations Meet Near Washington May 13-15, 2008 3Health News:Leading Veterans Service Organizations Meet Near Washington May 13-15, 2008 4Health News:Demanding Jobs May Pay Cognitive Dividends in Retirement 2Health News:Newer Prostate Cancer Treatment Similar to Traditional Surgery 2Health News:Newer Prostate Cancer Treatment Similar to Traditional Surgery 3
(Date:9/19/2014)... 2014 /PRNewswire-iReach/ -- Market Research Report on ... is a professional and in-depth market survey ... The report firstly reviews the basic information ... and manufacturing technology. The report then explores ... Hydrochloride listing their product specification, capacity, Production ...
(Date:9/19/2014)... 2014 Kiromic, LLC, a Lubbock ... Hance , the former chancellor of Texas Tech University, to ... in July 2014, after raising $1.2 billion for the university. ... Hance , the most successful chancellor in the history of ... as an investor, but also as our new vice chairman ...
(Date:9/19/2014)... -- 4WEB Medical announces the formal launch of the ... on the market today at this weekend,s American ... Chicago .  The Osteotomy Truss System is a ... 74 size options included in one versatile set. Previously ... to 18 implant sizes, which limited a surgeon,s ability ...
Breaking Medicine Technology:Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 24WEB Medical Unveils 3D-Printed Osteotomy Truss System 2
... PITTSBURGH , July 14 Mylan Inc. ... Pharma Holdings Limited, a privately held, global injectable pharmaceutical company ... provide Mylan not only an immediate entry into the North ... opportunities. This transaction is expected to be accretive to Mylan,s ...
... DEERFIELD, Ill. , July 14 ... Metabolic Drugs Advisory Committee and the Drug Safety and ... focused on reviewing the cardiovascular (CV) safety of rosiglitazone, ... two day discussion, Takeda Pharmaceuticals North America, Inc. ("Takeda") ...
Cached Medicine Technology:Mylan to Acquire Bioniche Pharma Global Injectable Pharmaceuticals Business 2Mylan to Acquire Bioniche Pharma Global Injectable Pharmaceuticals Business 3Mylan to Acquire Bioniche Pharma Global Injectable Pharmaceuticals Business 4Mylan to Acquire Bioniche Pharma Global Injectable Pharmaceuticals Business 5Takeda Responds to FDA Advisory Committee Recommendation 2Takeda Responds to FDA Advisory Committee Recommendation 3Takeda Responds to FDA Advisory Committee Recommendation 4Takeda Responds to FDA Advisory Committee Recommendation 5
... Plate Shaker are designed to give reliable performance ... microplates. The on/off button, power supply socket and ... of the unit. The speed knob is located ... of speed from a minimum 950 rpm to ...
ThermoPrep 3's two systems in "one" approach, its capability to accommodate up to two standard microplates and its user-selectable settings offers the versatility and throughput you need in today's l...
The BD LSR II can be configured with up to four fixed alignment lasers and the ability to detect up to 15 colors, utilizing a revolutionary optical design. The BD LSR II can be configured with a 488 ...
Modular flow cytometer with all options....
Medicine Products: