Navigation Links
Transplantation: 'molecular miscegenation' blurs the boundary between self and non-self
Date:10/30/2008

A new discovery by London biologists may yield new ways of handling the problem of transplant rejection. In a research article published in the November 2008 print issue of The FASEB Journal (http://www.fasebj.org), the scientists confirm the two-way transfer of a molecule (called "MHC") that instructs the immune system to tell "self" from "non-self." By disrupting the transfer of this molecule, newly transplanted organs should become "invisible" to the host's immune system. Such an advance would be considered a major medical breakthrough because current methods of preventing organ rejection involve weakening the host's immune system, which can lead to life-threatening infections.

"The medical potential of this finding is enormous," says Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "Understanding molecular miscegenation should not only make transplantation more widespread and effective, but also shed light on how microbes disrupt our body's immune apparatus for distinguishing self from non-self."

The researchers made this discovery when they transplanted kidneys or hearts from one set of mice into another, with each set of mice having a different version of the molecule being studied. The researchers then conducted tests to see if the molecules were transferred. In the recipient mice, the donated kidneys or hearts and the host tissue expressed both types of molecules. This is the first time that this transfer has been shown to happen in a living system.

Wilson Wong, senior researcher on the study from King's College London, states that although the findings are tantalizing, they represent only a very primitive understanding of this phenomenon. Nevertheless, he hopes "that this study will lead to a better understanding of the immune system to benefit the development of new therapies in areas related to transplantation."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... An in-depth computational analysis ... University of Pittsburgh points to eight genes that may explain why susceptibility to one ... the results of a study published today in the journal npj Schizophrenia. , ...
(Date:2/24/2017)... ... ... Healthcare Associates of McKinney announced today that they have moved ... Highway 121, Suite 210, McKinney, Texas 75070. It is in the heart of ... practice has grown, the need for more space has been paramount. This beautiful ...
(Date:2/24/2017)... ... ... The International Association of Eating Disorders Professionals (iaedp) announces the 2017 top five ... art competition. Selected from 15 submissions from around the nation, the top five finalists ... iaedp Symposium, March 22 – 26 in Las Vegas. , This year, the competition ...
(Date:2/24/2017)... Charlevoix, MI (PRWEB) , ... February 24, 2017 ... ... venue in Charlevoix, once again hosted their Military Wedding Giveaway, with the ... be hosted by Castle Farms with services generously donated from local vendors: A ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rare ... audience, will be participating in Rare Disease Day events, hosted by the Rare ... Rare Disease Report, a website, weekly e-newsletter and quarterly publication, will be conducting ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Feb. 23, 2017 Visiomed, the French ... since 1997, is changing the landscape of healthcare ... patients with pro-active, custom-made solutions. Recognizing the rising ... and affordable healthcare without walls, Visiomed has launched ... developed with healthcare professionals that is empowering the ...
(Date:2/23/2017)...  Genesis Healthcare Services has merged with Hospice Cloud, ... Bill Monast , President and CEO of Hospice ... Feltman , executives with Home Health Depot, Inc., the ... This acquisition helps Hospice Cloud maintain its position ... medical equipment (DME) solutions for the hospice industry. ...
(Date:2/23/2017)... , Feb. 23, 2017  Cogentix Medical, Inc. (NASDAQ: ... markets innovative proprietary products for the urology market, will ... year ended December 31, 2016 before the market open ... Company will host a conference call and webcast to ... March 9, 2017 at 11:00 a.m. Eastern Time (10:00 ...
Breaking Medicine Technology: