Navigation Links
Transplant drug stimulates immune memory
Date:6/21/2009

splant, Araki notes. That difference may have helped him recognize rapamycin's effects, he says.

Also, rapamycin's effects depend on the dose -- too high a dose will inhibit all T cells without regard to what type they are, he says.

Araki and Ahmed teamed up with Christian Larsen, MD, PhD, director of the Emory Transplant Center and chair of the Department of Surgery, to show that rapamycin had similar effects in rhesus macaques infected with vaccinia virus as in mice. That research was conducted at Emory's Yerkes National Primate Research Center.

Rapamycin, also called sirolimus, was approved by the FDA in 1999 for use after kidney transplants. It was discovered in a soil sample from Easter Island, whose Polynesian name is Rapa Nui.

Transplant patients usually don't take rapamycin by itself, so rapamycin's paradoxical effects may have been masked by other drugs, Larsen says.

For transplant patients, memory T cells can play a role in graft rejection, but they can also protect against infections.

"We are appreciating more and more that memory T cells respond differently to interventions than nave T cells and we have to pay close attention to the situation of the individual patient," Larsen says.

Scientists at the Emory Vaccine Center continue to study how T cells decide whether to become memory cells, because of their importance in maintaining the immune response against chronic infections such as HIV and hepatitis C.

The effects of rapamycin were seen even if Araki gave animals rapamycin only for a week after the infection began, suggesting that the beginning of the infection was when T cells were deciding whether or not to become memory cells.

By using an inhibitory technique (RNA interference) on the genes known to be targeted by rapamycin, Araki was able to show that rapamycin is acting on the CD8 T cells and not on other cells with which they interact.


'/>"/>

Contact: Holly Korschun
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Preclinical study suggests organ-transplant drug may aid in lupus fight
2. Study provides hope that some transplant patients could live free of antirejection drugs
3. Study provides hope that some transplant patients could live free of anti-rejection drugs
4. Advanced Age No Bar to Liver Transplant
5. Circulating fats kill transplanted pancreas cells, study shows
6. Sexual function affected by stem cell transplant according to long-term study
7. Dallas-Area Transplant Meeting Puts Spotlight on Key Issues
8. American Society of Transplantations Past President Testifies Before Congress at Forum on Organ Donation
9. Scientists Spot Key to Kidney Transplant Success
10. Fetal cell transplant could be a hidden link between childbirth and reduced risk of breast cancer
11. Patients over age 60 do well after liver transplantation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... As the category creator and world leader in ... is to transform and improve individual lives ... One such unique element is XoVita™, a proprietary ... an ingredient combination exclusive to Xoçai. This proprietary ... of Xoçai products and provides a wide-ranging class ...
(Date:7/25/2014)... July 26, 2014 2014 ... Gel Permeation Chromatography Industry” is a professional ... and China Gel Permeation Chromatography market. The ... including Gel Permeation Chromatography definition, classification, application, ... industry overview. This research covers the international ...
(Date:7/25/2014)... American motor vehicle owners who are at ... higher premiums for vehicle insurance on average. The Quotes ... provide SR22 insurance for high risk motorists this year ... network of local agencies providing direct price quotations for ... publicly available for any car owner to access. One ...
(Date:7/25/2014)... Ticket Down announces that ... the Guinness International Champions Cup match between international soccer ... Field on Sunday, July 27th. This well-known ... code SOCCER-2014 for added savings. , 2014 is turning ... fans in North America. Countless international soccer teams have ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 Sport ... for the recent Nike National Invitational Tournament (NIT) ... United States Junior National Tournament (USJN) in ... , The flooring for these prestigious national tournaments included ... 300,000 square feet of playing surface at McCormick Place ...
Breaking Medicine News(10 mins):Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 2Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 3Health News:Xocai-Asia Japanese Distributors in Hachioji, Japan Sanction Local Single-Source-Chocolate Investigative Report: MXI-Corp-Asia Discloses Direct-Sales Compensation Plan 4Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 2Health News:2014 China & Global GPC Industry - Gel Permeation Chromatography Development Trends Now at DeepResearchReports.com 3Health News:SR22 Insurance for High Risk Motorists Added to Local Quotes System at Insurer Website Online 2Health News:Liverpool FC vs. Olympiacos FC Tickets Soldier Field: Ticket Down Slashes Ticket Prices for Guinness International Champions Cup in Chicago on Sunday, July 27th 2Health News:Sport Court Provides All Sports Flooring for Basketball Events in Chicago and Washington D.C. 2
... Surgical,Company (Nasdaq: STAA ) today announced that it ... 28, 2008 on Tuesday, May 6, 2008,after the market ... webcast,on Tuesday, May 6, 2008 at 5:00 p.m. Eastern ... developments. The dial-in number for,the conference call is 866-250-3615 ...
... 24 Physicians Healthcare,Management Group, Inc. (Phyhealth) (Pink ... in partnership with physicians,today announced that Phyhealth Plan ... agreement with Advantica EyeCare to provide,comprehensive vision services ... in,the latter half of 2008., Mr. Robert ...
... Season are Those That Give Back and Support ... the Fight Against AIDS in Africa, NEW YORK, ... few weeks early at the INSPI(RED) Mothers,Brunch in New York City on ... Mya, and other (RED) supporters,to celebrate motherhood and to share the impact ...
... - Attorney Mark Werksman States ,Justice Was Served, -, ... Angeles City,Attorney,s Office dismissed a case against Yolanda McGriff, ... providing nursing and home,health care to a low-income, disabled ... while she was providing care,for her employer, a man ...
... The Department of,Justice announced today that the ... Andrew Bodnar, was indicted for his,role in lying ... involving the,popular blood-thinning drug, Plavix, used by heart ... the alleged illegal actions of Bodnar,related to the ...
... future research , , WEDNESDAY, April 23 (HealthDay News) -- ... disease appears to hasten progress of a related but ... new study. , The surprising findings, published in the ... Clinical Investigation , are significant, because individuals with frontotemporal ...
Cached Medicine News:Health News:STAAR Surgical Announces First Quarter 2008 Earnings Release Date and Conference Call 2Health News:Phyhealth Signs Agreement with Advantica EyeCare to Provide Vision Services for Pilot HMO 2Health News:Get INSPI(RED) This Mother's Day 2Health News:Get INSPI(RED) This Mother's Day 3Health News:Get INSPI(RED) This Mother's Day 4Health News:Case Dropped Against Healthcare Worker Who Was Arrested While Providing Care to an Elderly, Disabled Man in Los Angeles Home 2Health News:Former Bristol-Myers Squibb Senior Vice President Indicted for Lying to the Federal Government About Popular Blood-Thinning Drug 2Health News:Enzyme Beneficial to Alzheimer's Plays Darker Role in Other Dementia 2
(Date:7/25/2014)... According to a new market ... Insulin Market (Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting, Premixed, Modern and ... and Forecast (Value and Volume), 2013 - 2019", the ... in 2012 and is expected to grow at a ... USD 32.24 billion in 2019. Browse the ...
(Date:7/25/2014)... 25, 2014  IDEXX Laboratories, Inc. (NASDAQ: ... quarter of 2014 increased 11% versus the prior year ... for the second quarter of 2014 versus the prior ... in distributor inventory 2 . Earnings per diluted share ... 11% from the prior year period to $1.10."In the ...
(Date:7/25/2014)... 2014 Leading events organizer UBM Live ... the seventh year to São Paulo, Brazil ... 2014. The event will co-locate with Food Ingredients South America ... meeting point for the pharmaceutical industry.      (Logo: ... pharmaceutical sales are now exploring the South America ...
Breaking Medicine Technology:Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 2Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 4IDEXX Laboratories Announces Second Quarter Results 2IDEXX Laboratories Announces Second Quarter Results 3IDEXX Laboratories Announces Second Quarter Results 4IDEXX Laboratories Announces Second Quarter Results 5IDEXX Laboratories Announces Second Quarter Results 6IDEXX Laboratories Announces Second Quarter Results 7IDEXX Laboratories Announces Second Quarter Results 8IDEXX Laboratories Announces Second Quarter Results 9IDEXX Laboratories Announces Second Quarter Results 10IDEXX Laboratories Announces Second Quarter Results 11IDEXX Laboratories Announces Second Quarter Results 12IDEXX Laboratories Announces Second Quarter Results 13IDEXX Laboratories Announces Second Quarter Results 14IDEXX Laboratories Announces Second Quarter Results 15IDEXX Laboratories Announces Second Quarter Results 16IDEXX Laboratories Announces Second Quarter Results 17IDEXX Laboratories Announces Second Quarter Results 18IDEXX Laboratories Announces Second Quarter Results 19IDEXX Laboratories Announces Second Quarter Results 20IDEXX Laboratories Announces Second Quarter Results 21IDEXX Laboratories Announces Second Quarter Results 22IDEXX Laboratories Announces Second Quarter Results 23IDEXX Laboratories Announces Second Quarter Results 24IDEXX Laboratories Announces Second Quarter Results 25IDEXX Laboratories Announces Second Quarter Results 26IDEXX Laboratories Announces Second Quarter Results 27IDEXX Laboratories Announces Second Quarter Results 28IDEXX Laboratories Announces Second Quarter Results 29IDEXX Laboratories Announces Second Quarter Results 30IDEXX Laboratories Announces Second Quarter Results 31IDEXX Laboratories Announces Second Quarter Results 32IDEXX Laboratories Announces Second Quarter Results 33
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: