Navigation Links
Transplant Procedure Creates 'Hybrid' Immune System to Combat Rejection
Date:3/7/2012

By Randy Dotinga
HealthDay Reporter

WEDNESDAY, March 7 (HealthDay News) -- Researchers report that they were able to create a kind of hybrid immune system in patients who received kidney transplants, a process that appeared to allow the recipients' bodies to accept a foreign organ instead of trying to reject it.

There are caveats. The research is preliminary and only involved a tiny number of patients. Also, the required procedure is expensive and its long-term effects aren't known.

But if it works, the process -- which involves transferring bone marrow cells from the kidney donor to the patient -- could allow organ transplant recipients to avoid a lifetime of taking dozens of pills a day. "It's a huge step forward," said Dr. Suzanne Ildstad, director of the University of Louisville's Institute for Cellular Therapeutics, and co-author of the study published in the March 7 issue of Science Translational Medicine.

The immune system's job is to keep invaders out of the body, but it can do its work too well when a patient needs an organ transplant. "People think that once you get your transplant, everything is simple, but it's really far from that," Ildstad said.

Patients often have to take 15 to 25 pills a day to dampen their immune system, she said, and that can lead to complications such as infections, diabetes, high blood pressure and cancer.

"Even if you're perfect and take your drugs every day, every year there's a certain number of transplants lost to chronic rejection," Ildstad explained.

One way to get the immune system under control is to make it think like the immune system in the person who's donating the organ. That immune system of the donor would recognize the transplanted organ and not try to get rid of it.

In the new procedure, the researchers removed stem cells from the bone marrow of the kidney donors, put them through a special process designed to give them a boost, then inserted them into the organ recipients.

Essentially, the goal is to create a hybrid immune system -- part donor, part recipient -- in the bone marrow of the recipient. The marrow then creates cells in the immune system.

Of eight patients, five have not required any medications to suppress their immune systems, Ildstad said. Two of the patients take the medications at a low dose; one patient experienced complications related to blood poisoning and a blood clot in an artery to the kidneys.

The extra cost per patient beyond the expense of the transplant is about $50,000, Ildstad said. The next step is to determine whether the procedure would work for other kinds of transplants, she said.

Ildstad has a financial interest in Regenerex LLC, a company that participated in the study.

Dr. Tatsuo Kawai, a transplant specialist and associate professor of surgery at Harvard Medical School, said the findings are a "big deal." However, the safety of the procedure still needs to be confirmed, and it remains "highly risky" for the moment, said Kawai, who co-wrote a commentary accompanying the study.

In the commentary, Kawai noted some study weaknesses. Beside its small size, the study lacked a control group of patients who did not receive the new procedure, to allow comparisons. Also, he wrote that it might be difficult for other researchers to validate the findings, as the study doesn't fully disclose manufacturing details of the new process.

More information

For more about organ transplants, visit the U.S. National Library of Medicine.

SOURCES: Suzanne T. Ildstad, director, Institute for Cellular Therapeutics, University of Louisville, Kentucky; Tatsuo Kawai, M.D., Ph.D., associate professor, surgery, Harvard Medical School, Boston; March 7, 2012, Science Translational Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New drug for kidney transplant recipients effective in humans
2. WellPoint/Blue Cross Liver Transplant Denial Trial Starts Monday
3. Spanish Only, Please: Special Latino Clinic Launched For Potential Abdominal Transplant Patients
4. WellPoint/Blue Cross Liver Transplant Denial Trial Begins Today, Illustrates Need for Toughening of White House Reform Plan
5. Newer cornea transplant surgery shows short- and long-term promise
6. Cristophe Salon in Beverly Hills Teams Up with Mad Men Actor to Help Raise Money for His 17-Year-Old Cousins Heart Transplant
7. Two Babies Born a Year Apart After Ovary Transplant
8. Wounded Soldier Who Received Historic Cell Transplant Gets Standing Ovation at Diabetes Research Institute Benefit
9. Internal Anthem Blue Cross/WellPoint Document: Only Patients Who Push Back Get Covered Out of State Liver Transplants
10. Drug dramatically reduces nausea and vomiting in bone marrow transplant patients
11. Kidney Patients From Across South Carolina Visit State Capitol to Encourage Policies that Improve Patient Access to Life-Saving Dialysis and Transplant Care
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Transplant Procedure Creates 'Hybrid' Immune System to Combat Rejection
(Date:12/8/2016)... ... 08, 2016 , ... Russ DiGilio , founder and ... #QuackGivesBack campaign which supported local breast cancer organizations during National Breast Cancer Awareness ... Back initiative, and we’re very pleased with the participation in every franchisee’s ...
(Date:12/8/2016)... , ... December 08, 2016 , ... CURE Media Group, ... and advocacy groups, has aligned with Upstage Lung Cancer in efforts to combat lung ... announcement, Michael J. Hennessy, Jr said, “CURE Media Group is honored to team up ...
(Date:12/8/2016)... Fla (PRWEB) , ... December 08, 2016 , ... ... smarter modes of access for customers and employees that are both engaging and ... 7 with Service Smart Technology, the software company revealed today its plans to ...
(Date:12/8/2016)... ... 08, 2016 , ... STAT courier is pleased to announce that due to ... they are expanding their presence in Dallas. One of the most exciting parts for ... jobs to the Dallas and Forth Worth market. STAT takes pride in treating their ...
(Date:12/8/2016)... ... December 08, 2016 , ... Vida Health, the ... Series B led by Canvas Ventures . Other investors include Nokia Growth Partners ... mobile platform to serve more consumers who are managing chronic conditions or ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... 9, 2016 Research and Markets has announced ... report to their offering. ... The global travel vaccines market to grow at a ... covers the present scenario and the growth prospects of the global ... report considers the revenue generated from the sales of various vaccines ...
(Date:12/8/2016)... , Dec. 8, 2016 Australia Ophthalmic Lasers ... report, "Australia Ophthalmic Lasers Market Outlook to 2022", provides ... The report provides value, in millions of US dollars, ... segements - Excimer Lasers, Femtosecond Lasers and YAG Lasers. ... shares data for each of these market segements, and ...
(Date:12/8/2016)... KEY FINDINGS The global medical ... Various reasons for growth of the medical lifting sling ... chronic diseases, high recovery cost of injuries and government ... lifting sling refers to an assistive device that helps ... connect to the lift and hold the patient. It ...
Breaking Medicine Technology: