Navigation Links
Transplant May Treat Metabolic Disorders in Womb
Date:10/16/2009

Cord-blood stem cells given early in pregnancy might save infants most at risk, researchers say

FRIDAY, Oct. 16 (HealthDay News) -- U.S. researchers are testing a new approach in cord-blood transplants to treat genetic metabolic disorders in babies while they're still in the womb.

The new method uses a small, select number of therapeutic stem cells that have been treated to speed and improve engraftment (acceptance of the transplant by the body), explained Dr. Joanne Kurtzberg, a professor of pediatrics and pathology and director of the pediatric blood and marrow transplant program at Duke University Medical Center in Durham, N.C.

She and her team are studying the new procedure in a pilot trial open to pregnant women at risk for having children with fatal metabolic disorders, including Krabbe disease, metachromatic leukodystrophy, Pelizaeus-Maerzbacher disease, Tay-Sachs disease and Sandoff disease.

If untreated, these metabolic disorders can lead to bone, brain and central nervous system problems, and early death, the study authors noted in a Duke news release.

Donor cells used in the study will be made by the biopharmaceutical company Aldagen, Inc, which is a partner in the trial.

In many cases, cord-blood transplants after birth have proven successful in treating inherited metabolic disorders. Transplant timing is critical, Kurtzberg stressed.

"The idea is to give the baby cord-blood stem cells from a healthy donor that have the potential to provide healthy genes that can replace the ones that aren't working properly in the baby's own cells," Kurtzberg said in the news release.

In general, the earlier the transplant, the more likely it will work. That means that performing the transplant before the baby is born is ideal, she explained.

During the procedure, donor cells are injected directly into the fetus's abdomen at 12 to 14 weeks' pregnancy. At birth, the baby will be tested to see if the donor cells are present, and if they're fixing the malfunctioning genes. If not, the baby would be eligible for conventional cord-blood stem cell transplant within a few weeks.

More information

The Nemours Foundation has more about metabolism and metabolic disorders.



-- Robert Preidt



SOURCE: Duke Medicine, news release, Oct. 13, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Preclinical study suggests organ-transplant drug may aid in lupus fight
2. Study provides hope that some transplant patients could live free of antirejection drugs
3. Study provides hope that some transplant patients could live free of anti-rejection drugs
4. Advanced Age No Bar to Liver Transplant
5. Circulating fats kill transplanted pancreas cells, study shows
6. Sexual function affected by stem cell transplant according to long-term study
7. Dallas-Area Transplant Meeting Puts Spotlight on Key Issues
8. American Society of Transplantations Past President Testifies Before Congress at Forum on Organ Donation
9. Scientists Spot Key to Kidney Transplant Success
10. Fetal cell transplant could be a hidden link between childbirth and reduced risk of breast cancer
11. Patients over age 60 do well after liver transplantation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... ... August 17, 2017 , ... Inc. Magazine Unveils 36th Annual List of ... Three-Year Sales Growth of 3,004.8% , NEW YORK, August 16, 2017 – Inc. magazine ... prestigious ranking of the nation's fastest-growing private companies. The list represents a unique look ...
(Date:8/17/2017)... ... , ... Momkus McCluskey Roberts LLC recently announced it was naming ... the firm’s Commercial Litigation and Employment Law groups. , Ms. Parks joined Momkus ... of employment litigation, commercial litigation and business disputes. Her experience includes all aspects of ...
(Date:8/17/2017)... Yorba Linda, Ca (PRWEB) , ... August 17, 2017 , ... ... centrifuges are useful tools in the laboratory that we can no longer do without. ... to prolong the lifetime of your device. , In this webinar, attendees will learn ...
(Date:8/17/2017)... ... , ... A recent report indicates that circa 79 percent of 483 warning ... data integrity. The FDA outlines their expectations for quality critical instrumentation in the GMP ... the Beckman Coulter Life Sciences Virtual Trade Show Virtual Event, this webinar ...
(Date:8/16/2017)... ... August 16, 2017 , ... Summer days spent with family are priceless. ... put together suggestions for enjoying the season of sunshine. Add trying something new to ... family can join in on the fun. , Try Something New ...
Breaking Medicine News(10 mins):
(Date:8/10/2017)... Rehabilitation Network (PRN), acquired the long-standing outpatient rehabilitation clinic, Belmar ... The reputable clinic will continue to be co-owned and managed ... of four clinicians. Lipkin received his doctorate in physical therapy ... of experience with a strong background in manual therapy. ... clinic in and around the Denver ...
(Date:8/7/2017)... WARSAW, Ind. , Aug. 7, 2017 Zimmer ... in musculoskeletal healthcare, today announced that its Board of Directors ... stockholders for the third quarter of 2017. ... will be paid on or about October 27, 2017 to ... September 22, 2017.  Future declarations of dividends are subject to ...
(Date:8/4/2017)... , Aug. 4, 2017 The search ... shortly after a physician/patient consult has long been the ... was a notable focus of the largest meeting of ... according to healthcare market research firm Kalorama Information.  The ... testing (POCT) offerings or related supplies and software were ...
Breaking Medicine Technology: