Navigation Links
Transplant Drug Shrinks Tumors in Women With Rare Lung Disease
Date:1/10/2008

Sirolimus reduced growths by 50% for sufferers of LAM

THURSDAY, Jan. 10 (HealthDay News) -- Women who are struck by a rare lung disease could find their tumors shrink by 50 percent with the help of the transplant drug sirolimus, a new study suggests.

The Cincinnati researchers who made the discovery also demonstrated the drug might improve lung function in some patients over time.

Lymphangioleiomyomatosis (LAM), a disease that exclusively targets women, is characterized by progressive loss of lung function due to the invasion of abnormal muscle tissue that obstructs airways. In its early stages, LAM can be confused with emphysema because of its effects on breathing. People with LAM often need oxygen treatments and lung transplants as the disease continues its course. According to the American Lung Association, as many as 250,000 women worldwide might have the disease.

The new treatment was also effective in reducing tumors in patients suffering from tuberous sclerosis complex (TSC), a rare genetic multi-system disease.

The two diseases share a genetic mutation that affects the activation of the enzyme mTOR, which is responsible for controlling the growth and spread of cells. Sirolimus, a drug that is usually prescribed to prevent the rejection of transplanted organs, also prevents mTOR activity, according to the researchers. Sirolimus is also known as rapamycin (Rapamune).

Publishing in the Jan. 10 edition of the New England Journal of Medicine, the researchers concluded that sirolimus has the potential to help patients with either disease avoid surgery for the tumor angiomyolipomata, common to both conditions.

"Less invasive therapies are clearly needed to treat the angiomyolipomata that people with TSC and LAM develop, and a drug that maintains or shrinks tumor size may reduce the need for procedures such as surgery," study author Dr. John Bissler, a physician/scientist in the division of nephrology and hypertension at Cincinnati Children's Hospital, said in a prepared statement. "Our data suggest that mTOR inhibition with sirolimus may hold promise for treating these and other disease manifestations in patients with TSC and LAM."

Bissler and his colleagues treated 20 patients who had angiomyolipomata tumors with sirolimus for 12 months. They reported that, at the end of the year, the tumors shrank by about half. Eleven of the patients who had LAM and took sirolimus for the year also showed a 10 percent to 15 percent improvement in expiratory air flow, a standard measure of lung function.

The researchers followed up with 18 of the original patients after a year without the sirolimus treatment. They found that tumor size had increased to about 85 percent of original pre-treatment size.

Tumors in five of the original patients, though, were 30 percent smaller than their original size after a year without the medication. The study authors theorized that this could be a result of apoptosis, a kind of programmed cell death.

After a year without treatment, the patients' lung function declined but was still better than what could be expected from similar patients after two years without any intervention, the researchers said. The improved lung function could be because of the lessening of obstructions and trapped gas in the lungs, the researchers noted.

Patients reported side effects from the sirolimus treatment that included mouth sores, diarrhea, upper respiratory infections and joint pain.

The researchers acknowledged that the small study needs further follow-up. A phase III clinical trial of the drug as a treatment for LAM patients is planned, they said.

More information

To learn more about LAM, visit the American Lung Association.



-- Madeline Vann



SOURCE: University of Cincinnati, news release, Jan. 9, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Rural Residents Get Fewer Organ Transplants: Study
2. Childrens Hospital physicians publish review of transplant issues in patients with biliary atresia
3. RNs Statement on Death of Nataline Sarkisyan: CIGNA Should Have Listened to her Doctors and Approved the Transplant a Week Ago
4. UCLA Program Aims to Revolutionize Kidney Transplants
5. Phylonix granted broad European patent for transplanting human cells into zebrafish
6. Transplanted Bone Marrow Cells Aid Nerve Regeneration
7. High-dose chemo and stem cell transplant shows little or no survival benefit for breast cancer
8. Partial Face Transplant Patient Doing Well
9. VELCADE(R) (Bortezomib) for Injection Based Therapy Produced Significant Complete Remission Rates Pre- and Post-Transplantation in IFM Phase III Front-Line Multiple Myeloma Trial
10. Gentler chemotherapy before stem cell transplant causes long-term remission of follicular lymphoma
11. Cell Transplants Hold Promise for Heart Attack Survivors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Transplant Drug Shrinks Tumors in Women With Rare Lung Disease
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... , ... October 12, 2017 , ... The American College ... to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in ... , In honor of Morris F. Collen, a pioneer in the field of medical ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... for the 49th Congress of the International Society of Paediatric Oncology (SIOP) ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief Medical Officer ... physician colleagues, skilled nursing facility medical directors and other clinicians at various events ... Care." , "At many of these conferences we get to educate other physicians, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 11, 2017  BioPharmX Corporation (NYSE MKT: BPMX) researchers ... an innovative way to use nonlinear optical imaging to ... new drugs. ... will show how researchers from BioPharmX and the Wellman ... used a suite of imaging techniques in what is ...
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
(Date:10/4/2017)... OBP Medical , a leading ... today announced regulatory approval from Brazil,s ... Nacional de Vigilância Sanitária (ANVISA)) to market ... with integrated LED light source and smoke evacuation ... of a tissue pocket or cavity during surgical ...
Breaking Medicine Technology: