Navigation Links
Transparent zebrafish help researchers track breast cancer
Date:10/22/2007

What if doctors could peer through a patients skin and see a cancer tumor growing? Theyd be able to study how tumor cells migrate: how they look, how they interact with the blood system to find nourishment to grow and spread through the body.

Scientists at the University of California, San Diego (UCSD) School of Medicine cant look through human skin. But a small, tropical minnow fish common to aquariums has given UCSD researchers a window for viewing live, human cancer cells in action. Working with transparent zebrafish to study one of the most aggressive forms of cancer, inflammatory breast cancer, has led to their discovery of how two proteins interact in the metastasis of breast cancer. The study led by Richard Klemke, Ph.D., professor of pathology at UCSD School of Medicine and the UCSD Moores Cancer Center, will be published in the Proceedings of the National Academy of Science online edition the week of October 22-26.

By watching human breast cancer cells in real time in the live transgenic zebrafish, we were able to determine that two proteins are required in order for breast tumor cells to complete the most critical step of metastasis entering the blood vessels, said Konstantin Stoletov, Ph.D., of the department of pathology at the UC-San Diego School of Medicine, first author of the paper.

The scientists discovered that two proteins work together to allow cancerous breast tumors to enter the blood vessels, thus promoting metastasis. The first is vascular endothelial growth factor (VEGF), a protein made by cancerous cells that stimulates new blood vessel formation, or angiogenesis. The second is a small protein called RhoC that is involved in cell movement or migration, and is overexpressed in highly metastatic forms of breast cancer.

The researchers found that neither VEGF nor RhoC alone interact with blood vessels to allow the cancerous tumor to enter the blood vessels, or intravasate. But togethe
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. McDonalds: French Fries, Transparent to more Trans -Fats
2. New Studies On Zebrafish Could Aid in Treating Birth Defects
3. Regrowth of Zebrafishs Tail Fin may Offer Clues for Treating Human Injuries
4. Cocaine Exposure can Alter Neuronal Development in Zebrafish
5. Researchers urge caution in using ear tube surgery
6. Researchers Scale to assess the Severity of Epilepsy in Kids
7. Researchers identify the early makers of Neonatal Sepsis
8. OHSU Researchers Announce New Discovery
9. Researchers Identify Gene Connected To Bipolar Disorder
10. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
11. Researchers trick Alzheimers Enzyme
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Liberty University has received accreditation for its resident Clinical ... for Accreditation of Counseling & Related Educational Programs (CACREP). ... & Family Studies , is under the leadership of Dr. ... Behavioral Sciences. Prior to the formation of the new school, ...
(Date:1/22/2015)... 22, 2015 Padre Murphy's and Owner Tom ... Pro Player Health Alliance (PPHA). The PPHA's passion ... getting everyone, including NFL greats, treated for obstructive sleep apnea ... groups supporting the cause in the valley. The most recent ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 AngelWeddingDress, the ... of 2015 maternity wedding dresses. View website ... are looking for maternity wedding dresses online for a ... gowns with high quality for them. Its maternity wedding ...
(Date:1/22/2015)... 2015 Autocarinsurancebest.com has released a new blog ... auto insurance policy . , Auto insurance quotes help ... is no longer necessary to call an agent or visit ... online on a single website: http://autocarinsurancebest.com/ . , Every ...
(Date:1/22/2015)... Jolla, Calif. (PRWEB) January 22, 2015 ... Assemblymembers Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) ... for their leadership in advancing biotechnology, biomedical science, ... Bonilla and Olsen each received the “2014 Life ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3
... 2008 Over 1.3 million Americans suffer from rheumatoid ... RA is a disabling condition, and can lead to ... of function in affected areas. A recent study published ... Periodontology , the official publication of the American Academy ...
... 10 The famed nonprofit Los Angeles,Jewish Home -- ... -- has completed a series of program and building ... campuses. As a,result, for the first time in many ... residents in need of skilled nursing care. In,addition, the ...
... on Healthy Living and Eating, ROSEMONT, Ill., ... partnering with the U.S. Department of Agriculture (USDA) ... and make healthier,lifestyle choices as part of the ... End Childhood Obesity.", The USDA,s Center for ...
... Nearly 213,000 treated in emergency departments annually - more ... ATLANTA, June 10 Almost 213,000 people were,treated each ... to 2005, according to a Centers for Disease Control ... Of those injured, about 109,000 (51.5 percent) were young ...
... young people postpone the start of sexual activity, according to ... who made pledges to remain virgins until they are married ... study period than other youth who were similar to them, ... the study published online by the Journal of Adolescent ...
... June 10 As government,authorities reel from a record ... outbreak, a new book brings to light the science ... technology being,promoted by the food and nuclear industries., ... Death of Food is timely and fact-filled. The book ...
Cached Medicine News:Health News:Researchers uncover higher prevalence of periodontal disease in rheumatoid arthritis patients 2Health News:Los Angeles Jewish Home Increases Resident Capacity and Adds New Programs to Address Community Needs 2Health News:National Dairy Council Joins USDA in 'Partnering With MyPyramid' 2Health News:New CDC Study First to Present National Outdoor Recreational Injury Estimates 2Health News:Study finds virginity pledges may help postpone intercourse among youth 2Health News:New Book Reveals Decades-Long Food Safety PR Scam 2
(Date:1/23/2015)... , Jan. 23, 2015 For the pharmaceutical industry, marketplace ... with payers. Likewise, the importance of the managed markets function ... continue to grow as payer formularies and provider networks play ... At the same time, managed markets leaders must continually ...
(Date:1/23/2015)... , Jan. 23, 2015 Research and Markets ( ... Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and ... Video communication has been the topic of fascination since ... United States and the Soviet Russia. Earlier even ...
(Date:1/23/2015)... 23, 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ... Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and ... Size, Share, Growth, Trends and Forecast 2014 - 2020" ... At present, the global market for urinary catheters is ...
Breaking Medicine Technology:As Payer Influence Rises, Pharmaceutical Companies work to Optimize the Managed Markets Function 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3
MediNotes e is an EMR design which utilizes a "tab concept for navigation. MediNotes e can display multiple patients, encounter notes, workflow items, patient flow, messages, alerts, and more, all in...
... Accumedics Electronic Medical ... real-time HL7 EDI Interface ... demographics, and provides custom ... Record Software Interface is ...
... RecordsTFC System supports approaches to ... patient/resident record keeping functions using ... multiple facilities and cut across ... clinics, community clinics, physician, agency, ...
... developed expressly to help you manage ... the right combination of EMR software, ... can be confident your practice is ... What's more, athenaClinicals seamlessly integrates with ...
Medicine Products: