Navigation Links
'Transparent' Mouse Brain Could Shed Light on Human Brain Health
Date:4/10/2013

WEDNESDAY, April 10 (HealthDay News) -- Scientists who developed a way to make a mouse brain transparent say the process could revolutionize the way the human brain is studied.

A transparent brain can be examined whole, without the need to slice or section it. The three-dimensional complexity of molecular structures and wiring are intact and can be assessed and probed with visible light and chemicals, according to the Stanford University researchers.

The chemical process for making the brain transparent -- called CLARITY -- is done after it is removed from the animal. The process involves replacing the brain's lipids (fatty molecules) with a hydrogel, according to a study published online April 10 in the journal Nature.

The research described in the study was performed primarily on a mouse brain, but the investigators have used the same process on zebrafish and on preserved human brain samples, and achieved similar results.

"Studying intact systems with this sort of molecular resolution and global scope -- to be able to see the fine detail and the big picture at the same time -- has been a major unmet goal in biology, and a goal that CLARITY begins to address," team leader Karl Deisseroth, a bioengineer and psychiatrist, said in a Stanford news release.

Dr. Thomas Insel, director of the U.S. National Institute of Mental Health (NIMH), said in the news release: "This feat of chemical engineering promises to transform the way we study the brain's anatomy and how disease changes it. No longer will the in-depth study of our most important three-dimensional organ be constrained by two-dimensional methods."

The NIMH provided funding for the research.

"CLARITY promises to revolutionize our understanding of how local and global changes in brain structure and activity translate into behavior," Paul Frankland, a senior scientist in neurosciences and mental health at the Hospital for Sick Children Research Institute in Toronto, said in the news release. He was not involved in the research.

Experts note that success in animal research often does not translate to success in human research.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about the brain.

-- Robert Preidt

SOURCE: Stanford University, news release, April 10, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New American Chemical Society video series shines a light on transparent solar cells
2. T9 LED Tube with Transparent PC Cover from Zhongtian Lighting
3. Study: Transparent pricing doesnt curb doctors use of high-cost hospital imaging tests
4. Mouse Study Hints at New Path for Diabetes Treatment
5. This mousetrap may save lives
6. Its Not Just What You Eat, Its When You Eat, Mouse Study Finds
7. Belly Membrane May Regulate Immune System, Mouse Study Finds
8. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
9. New mouse model helps explain gene discovery in congenital heart disease
10. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
11. Scientists develop mouse model that could lead to new therapies for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Transparent' Mouse Brain Could Shed Light on Human Brain Health
(Date:1/19/2017)... ... January 19, 2017 , ... In 2009, Carol Bryan ... resulted in severe facial disfiguration. After four frightening years of isolation and emotional ... Medical Center, who removed the substances in a partial facial transplant through eight ...
(Date:1/19/2017)... ... January 19, 2017 , ... Allegheny Health Network (AHN) ... who seek access to the Network’s programs and services in the greater Pittsburgh region. ... care appointments will be offered one for that same afternoon. , AHN ...
(Date:1/19/2017)... ... ... St. Catherine’s Village announced that a limited number of rooms have become available ... grounds of the St. Catherine’s Village campus in Madison, Mississippi that accommodates 120 residents ... Mississippi for the second year in a row by readers of the Clarion-Ledger. , ...
(Date:1/19/2017)... ... January 19, 2017 , ... Bill Howe Plumbing, Heating ... the American Heart Association; “Howe” Healthy is Your Heart Drawing Contest The ... active. Each year, Bill Howe Plumbing, Heating & Air receives over 600 entries. The ...
(Date:1/19/2017)... ... January 19, 2017 , ... Infinity® Massage Chairs announced today that Dan ... sales and marketing strategies. Grover comes with a total of 15 years experience in ... years as Executive Vice President of Direct Sales at Traeger® Wood Pellet Grills. ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... N.J. , Jan. 18, 2017   Regenicin, ... a biotechnology company specializing in the development and commercialization ... damaged tissues and organs, recently reported the Company,s operating ... for 2017. As the Company described in ... been a year of substantial accomplishments. The Company,s contract ...
(Date:1/18/2017)... and PUNE, India , January 18, 2017 /PRNewswire/ ... titled, "Polyphenol Market by Product Type and by Application: Global Opportunity Analysis and ... million in 2015, and is expected to reach $1,127 million by 2022, growing ... market in 2015, with two-fifths share, in terms of revenue. ... ...
(Date:1/18/2017)... Jan 18, 2017 Research and Markets has ... Drugs Market 2017-2021" report to their offering. ... The global CINV drugs market ... Global Thoracic Surgery Market 2017-2021, has been prepared ... The report covers the market landscape and its growth prospects over ...
Breaking Medicine Technology: