Navigation Links
'Transparent' Mouse Brain Could Shed Light on Human Brain Health
Date:4/10/2013

WEDNESDAY, April 10 (HealthDay News) -- Scientists who developed a way to make a mouse brain transparent say the process could revolutionize the way the human brain is studied.

A transparent brain can be examined whole, without the need to slice or section it. The three-dimensional complexity of molecular structures and wiring are intact and can be assessed and probed with visible light and chemicals, according to the Stanford University researchers.

The chemical process for making the brain transparent -- called CLARITY -- is done after it is removed from the animal. The process involves replacing the brain's lipids (fatty molecules) with a hydrogel, according to a study published online April 10 in the journal Nature.

The research described in the study was performed primarily on a mouse brain, but the investigators have used the same process on zebrafish and on preserved human brain samples, and achieved similar results.

"Studying intact systems with this sort of molecular resolution and global scope -- to be able to see the fine detail and the big picture at the same time -- has been a major unmet goal in biology, and a goal that CLARITY begins to address," team leader Karl Deisseroth, a bioengineer and psychiatrist, said in a Stanford news release.

Dr. Thomas Insel, director of the U.S. National Institute of Mental Health (NIMH), said in the news release: "This feat of chemical engineering promises to transform the way we study the brain's anatomy and how disease changes it. No longer will the in-depth study of our most important three-dimensional organ be constrained by two-dimensional methods."

The NIMH provided funding for the research.

"CLARITY promises to revolutionize our understanding of how local and global changes in brain structure and activity translate into behavior," Paul Frankland, a senior scientist in neurosciences and mental health at the Hospital for Sick Children Research Institute in Toronto, said in the news release. He was not involved in the research.

Experts note that success in animal research often does not translate to success in human research.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about the brain.

-- Robert Preidt

SOURCE: Stanford University, news release, April 10, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New American Chemical Society video series shines a light on transparent solar cells
2. T9 LED Tube with Transparent PC Cover from Zhongtian Lighting
3. Study: Transparent pricing doesnt curb doctors use of high-cost hospital imaging tests
4. Mouse Study Hints at New Path for Diabetes Treatment
5. This mousetrap may save lives
6. Its Not Just What You Eat, Its When You Eat, Mouse Study Finds
7. Belly Membrane May Regulate Immune System, Mouse Study Finds
8. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
9. New mouse model helps explain gene discovery in congenital heart disease
10. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
11. Scientists develop mouse model that could lead to new therapies for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Transparent' Mouse Brain Could Shed Light on Human Brain Health
(Date:2/19/2017)... ... ... Braun Industries will be participating as an exhibitor at EMS Today 2017. ... 23-25, 2017 at the Calvin L. Rampton Salt Palace Convention Center in Salt Lake ... on display. , “JEMS is a leader in EMS news and education. ...
(Date:2/19/2017)... ... February 19, 2017 , ... ... in better care, and MEDfx and the Delaware Health Information Network (DHIN) have ... As the nation’s first state-wide health information exchange, DHIN stores and shares real-time ...
(Date:2/18/2017)... ... February 17, 2017 , ... ... Axendia, **FDAnews Free Webinar**, March 1, 2017 — 1:30 p.m. – 2:30 ... regulatory burden? Pay dividends in enhanced and predictable product performance? Streamline processes ...
(Date:2/18/2017)... ... 17, 2017 , ... Butler Mobility invited Ken Matthews to visit its manufacturing ... Ken was impressed with the safety and reliability of the Stannah Stairlift as ... show. This endorsement by Ken Matthews can be heard on News Radio WHP ...
(Date:2/18/2017)... ... February 17, 2017 , ... Park Cities Pet Sitter ... Show on the Pet Life Radio network. The episode, which was posted this ... topics including: what factors led to Park Cities Pet Sitter’s being awarded the 2017 ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... Research and Markets has announced the addition of ... report to their offering. ... Traditional medical devices include devices (e.g., ... implantables, large endoscopes, needle based drug delivery, lab based diagnostics ... to three decades for the treatment and management of various ...
(Date:2/16/2017)... -- DaVita Inc. (NYSE: DVA ) today announced ... Net income attributable to DaVita Inc. for ... million, or $0.80 per share and $880 million, or $4.29 ... to DaVita Inc. for the quarter and year ended December ... million, or $0.98 per share, and $789 million, or $3.85 ...
(Date:2/16/2017)... 16, 2017  Aralez Pharmaceuticals Inc. (NASDAQ: ... today announced that executive management will participate in the ... February 22-23, 2017. Adrian Adams , Chief Executive ... 1:35 p.m. local time on Wednesday, February 22, 2017. ... the event may be accessed from the Investors section ...
Breaking Medicine Technology: