Navigation Links
'Transparent' Mouse Brain Could Shed Light on Human Brain Health

WEDNESDAY, April 10 (HealthDay News) -- Scientists who developed a way to make a mouse brain transparent say the process could revolutionize the way the human brain is studied.

A transparent brain can be examined whole, without the need to slice or section it. The three-dimensional complexity of molecular structures and wiring are intact and can be assessed and probed with visible light and chemicals, according to the Stanford University researchers.

The chemical process for making the brain transparent -- called CLARITY -- is done after it is removed from the animal. The process involves replacing the brain's lipids (fatty molecules) with a hydrogel, according to a study published online April 10 in the journal Nature.

The research described in the study was performed primarily on a mouse brain, but the investigators have used the same process on zebrafish and on preserved human brain samples, and achieved similar results.

"Studying intact systems with this sort of molecular resolution and global scope -- to be able to see the fine detail and the big picture at the same time -- has been a major unmet goal in biology, and a goal that CLARITY begins to address," team leader Karl Deisseroth, a bioengineer and psychiatrist, said in a Stanford news release.

Dr. Thomas Insel, director of the U.S. National Institute of Mental Health (NIMH), said in the news release: "This feat of chemical engineering promises to transform the way we study the brain's anatomy and how disease changes it. No longer will the in-depth study of our most important three-dimensional organ be constrained by two-dimensional methods."

The NIMH provided funding for the research.

"CLARITY promises to revolutionize our understanding of how local and global changes in brain structure and activity translate into behavior," Paul Frankland, a senior scientist in neurosciences and mental health at the Hospital for Sick Children Research Institute in Toronto, said in the news release. He was not involved in the research.

Experts note that success in animal research often does not translate to success in human research.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about the brain.

-- Robert Preidt

SOURCE: Stanford University, news release, April 10, 2013

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New American Chemical Society video series shines a light on transparent solar cells
2. T9 LED Tube with Transparent PC Cover from Zhongtian Lighting
3. Study: Transparent pricing doesnt curb doctors use of high-cost hospital imaging tests
4. Mouse Study Hints at New Path for Diabetes Treatment
5. This mousetrap may save lives
6. Its Not Just What You Eat, Its When You Eat, Mouse Study Finds
7. Belly Membrane May Regulate Immune System, Mouse Study Finds
8. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
9. New mouse model helps explain gene discovery in congenital heart disease
10. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
11. Scientists develop mouse model that could lead to new therapies for liver cancer
Post Your Comments:
Related Image:
'Transparent' Mouse Brain Could Shed Light on Human Brain Health
(Date:11/27/2015)... ... 28, 2015 , ... There is only one major question facing all law ... , This question has not been an easy question to answer. Especially when the ... the younger workforce don’t share the same discipline around working long hours. , ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... According to ... out by the University of Toronto and the University of British Columbia suggested that ... for head injuries. The article explains that part of the reason for the controversial ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... affecting the health care in America. As people age, more care is needed, ... costs are rising, and medical professionals are being overworked. The forgotten part of ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... safe and convenient way to dispense prescription medications at home, so he invented ... way to monitor and dispense prescription medications. In doing so, it could help ...
(Date:11/27/2015)... ... November 27, 2015 , ... Lizzie’s Lice Pickers just ... is offering customers 10% off of their purchase of lice treatment product. In addition, ... price. According to a company spokesperson. “Finding lice is a sure way to ruin ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... 2015 CIVCO Medical Solutions will demonstrate ... Radiological Society of North America ... November 29 – December 4, 2015. The ... customers unrivaled versatility, enhanced user experience and deliver ... --> --> ...
(Date:11/27/2015)... YORK , November 27, 2015 ... system is set to go online. The potential to ... processes is vast and far from fully exploited as ... to patient health records, either via mobile tablet or ... ) --> ) --> ...
(Date:11/27/2015)... , Nov. 27, 2015 Research and Markets ... "Global Intrauterine Devices Market 2015-2019" report to ... --> In this report, the author the present ... market for 2015-2019. To calculate the market size, the ... type of products: Hormonal IUDs and copper IUDs. The ...
Breaking Medicine Technology: