Navigation Links
'Transparent' Mouse Brain Could Shed Light on Human Brain Health
Date:4/10/2013

WEDNESDAY, April 10 (HealthDay News) -- Scientists who developed a way to make a mouse brain transparent say the process could revolutionize the way the human brain is studied.

A transparent brain can be examined whole, without the need to slice or section it. The three-dimensional complexity of molecular structures and wiring are intact and can be assessed and probed with visible light and chemicals, according to the Stanford University researchers.

The chemical process for making the brain transparent -- called CLARITY -- is done after it is removed from the animal. The process involves replacing the brain's lipids (fatty molecules) with a hydrogel, according to a study published online April 10 in the journal Nature.

The research described in the study was performed primarily on a mouse brain, but the investigators have used the same process on zebrafish and on preserved human brain samples, and achieved similar results.

"Studying intact systems with this sort of molecular resolution and global scope -- to be able to see the fine detail and the big picture at the same time -- has been a major unmet goal in biology, and a goal that CLARITY begins to address," team leader Karl Deisseroth, a bioengineer and psychiatrist, said in a Stanford news release.

Dr. Thomas Insel, director of the U.S. National Institute of Mental Health (NIMH), said in the news release: "This feat of chemical engineering promises to transform the way we study the brain's anatomy and how disease changes it. No longer will the in-depth study of our most important three-dimensional organ be constrained by two-dimensional methods."

The NIMH provided funding for the research.

"CLARITY promises to revolutionize our understanding of how local and global changes in brain structure and activity translate into behavior," Paul Frankland, a senior scientist in neurosciences and mental health at the Hospital for Sick Children Research Institute in Toronto, said in the news release. He was not involved in the research.

Experts note that success in animal research often does not translate to success in human research.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about the brain.

-- Robert Preidt

SOURCE: Stanford University, news release, April 10, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New American Chemical Society video series shines a light on transparent solar cells
2. T9 LED Tube with Transparent PC Cover from Zhongtian Lighting
3. Study: Transparent pricing doesnt curb doctors use of high-cost hospital imaging tests
4. Mouse Study Hints at New Path for Diabetes Treatment
5. This mousetrap may save lives
6. Its Not Just What You Eat, Its When You Eat, Mouse Study Finds
7. Belly Membrane May Regulate Immune System, Mouse Study Finds
8. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
9. New mouse model helps explain gene discovery in congenital heart disease
10. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
11. Scientists develop mouse model that could lead to new therapies for liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Transparent' Mouse Brain Could Shed Light on Human Brain Health
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
(Date:6/23/2016)... , , , WHEN: ... , , , , LOCATION: , , , Online, with ... , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice ... Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... industry is witnessing an exceptional era. Several new demand spaces, such ...
(Date:6/23/2016)... Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new ... affiliate in Latin America . ... ... ... ...
Breaking Medicine Technology: