Navigation Links
Transparent Fish Gives New Window on Disease
Date:2/6/2008

Scientists watched as cancer cells spread throughout living zebrafish's body

TUESDAY, Feb. 5 (HealthDay News) -- Medical researchers can now get a clearer view into human biology and disease with a newly developed, totally transparent breed of zebrafish, a common model for medical research.

According to the Children's Hospital Boston researchers who developed the new breed, zebrafish are genetically similar to humans. This new transparent form of the small fish will provide researchers with a direct view of its internal organs and the opportunity to observe processes such as the spread of cancer or blood production after bone marrow transplant, as they occur in a living organism.

In normal zebrafish, embryos are transparent but adults become opaque. The new permanently transparent fish, created by mating two existing zebrafish breeds, is described in the Feb. 7 issue of Cell Stem Cell.

Currently, researchers studying human diseases in animals induce the illness and allow it to progress, then kill and dissect the animals. But that approach is bound to miss something in cancer and other rapidly changing processes, according to the team that developed the transparent zebrafish.

"It's like taking a photograph when you need a video," Dr. Richard White, a clinical fellow in the Stem Cell Program at Children's Hospital Boston and an instructor of medicine at the Dana-Farber Cancer Institute, said in a prepared statement.

In his first experiment with the transparent zebrafish, White viewed how cancer spreads.

"The process by which a tumor goes from being localized to widespread and ultimately fatal is the most vexing problem that oncologists face," White said. "We don't know why cancer cells decide to move away from their primary site to other parts of the body."

He placed a fluorescent melanoma (skin cancer) tumor in the abdominal cavity of a transparent zebrafish and, using a microscope, saw the cancer cells begin to spread within five days. The melanoma cells moved toward the skin after leaving the abdominal cavity.

"This told us that when tumor cells spread to other parts of the body, they don't do it randomly. They know where to go," White said.

He plans to investigate cancer cell homing and to look for ways to prevent spreading cancer cells from finding their way to their intended destination.

In another experiment, White investigated how transplants of blood stem cells can help rebuild healthy blood in cancer patients after treatment. He irradiated bone marrow in a transparent zebrafish and then transplanted fluorescent blood-forming stem cells from another zebrafish.

After four weeks, White could see that the transplanted fluorescent stem cells had migrated and grown in the fish's bone marrow. Even individual stem cells were visible.

Being able to observe how stem cells embed and build blood in the transparent fish may help scientists find faster ways to help rebuild healthy blood in cancer patients. For example, drugs and genes could be tested in the fish and scientists could directly view the effects, White said.

Because their brain, heart and digestive tract are readily visible, the transparent fish will enable researchers to study genetic defects in these organs and learn more about a variety of disorders ranging from Alzheimer's disease to inflammatory bowel disease, White added.

More information

The University of Oregon has more about zebrafish.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, Feb. 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Transparent zebrafish help researchers track breast cancer
2. AstraZeneca Gives $1.5 million to Support North Carolina Worksite Wellness Project
3. EPA Gives $97,204 to Ohio to Raise Awareness of Environmental Health Risks to Women
4. United States Gives $12 Million to Pediatric AIDS Foundation Initiative
5. What gives us fingertip dexterity?
6. Evolution of human genomes guardian gives people unique protections from DNA damage
7. American Lung Association Report Gives Illinois Mixed Grades
8. Jan Marini Skin Research Gives Familiar Logo a Facelift
9. DaVita Nurse Gives Keynote Speech to St. Georges Hospital Vascular Access Annual Meeting in London
10. As More Americans Live to 100, Long Term Care Insurance Leader Gives Health Assist
11. Blue Cross of California Gives $30,000 in Holiday Donations to Food Banks Throughout the State
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Transparent Fish Gives New Window on Disease
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Agile Software Development, has been awarded a contract by the Center for Medicare ... (BPA) aims to accelerate the enterprise use of Agile methodologies in a consistent ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance ... management, will showcase a range of technology and learning solutions at the 68th ... and Expo to be held October 14–18, 2017 at the Mandalay Bay Resort ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion ... notable awards. Ranked as number one in the South Florida ... time in Inc. 5000 yearly list, the national specialty pharmacy ... Armando Bardisa will soon be honored by SFBJ ... Set to receive his award in ...
(Date:9/25/2017)... R.I. , Sept. 25, 2017  EpiVax, ... assessment, vaccine design, and immune-engineering today announced the ... on the development of personalized therapeutic cancer vaccines. ... has provided exclusive access to enabling technologies to ... Eng., MBA will lead EpiVax Oncology as Chief ...
(Date:9/22/2017)... Sept. 22, 2017 AVACEN Medical (AVACEN) announced ... now successfully helping those with the widespread pain associated ... diagnosed Amanda in Essex, England ... my hair, experiencing no sleep at all, tremendous pain, ... I cannot recommend [the AVACEN 100] enough, how this ...
Breaking Medicine Technology: