Navigation Links
Transfusions of 'Older' Blood Don't Work as Well
Date:3/19/2008

Mortality, complication rates higher than with freshly stored units, study finds

WEDNESDAY, March 19 (HealthDay News) -- Heart-surgery patients who get transfusions of blood that has been stored for more than 14 days do worse than those who get newer blood, a new study shows.

In-hospital death rates, incidence of complications and long-term death rates were higher for those getting older blood, conclude physicians at the Cleveland Clinic.

While other studies have shown the same effect, "we're not necessarily advocating a policy change at this time," said Dr. Colleen Gorman Koch, vice chairman of education and research at the clinic's department of cardiothoracic anesthesia.

But Koch said she and her colleagues are conducting a controlled trial that could lead to a change in the current policy of the U.S. Food and Drug Administration, which says that blood can be stored for as long as 42 days before transfusion.

The trial, which will closely track the condition of heart-surgery patients who get transfusions, will include 2,000 participants, Koch said. Fewer than 100 have been enrolled so far, and results are not expected for at least two years, she said.

The newly reported study, published in the March 20 issue of the New England Journal of Medicine, examined almost 2,900 people who underwent coronary artery bypass procedures or heart valve operations and who got blood that had been stored for 14 days or less. They were compared with more than 3,100 people undergoing those procedures who got blood that had been stored for at least 14 days.

The study found that 2.8 percent of those getting older blood died in the hospital, compared to 1.7 percent of those getting fresher blood. The incidence of infection among the older-blood group was 4.0 percent, compared to 2.8 percent in the fresh-blood group. And in the year following the transfusions, 11.0 percent of those getting older blood died, compared to 7.4 percent of those getting newer blood.

"It's nice to know that other people are coming around to the same conclusion as we did," said Dr. Sunil Rao, assistant professor of medicine at Duke University Medical Center's Division of Cardiology, who worked with Dr. Jonathan Stamler at Duke on a series of studies showing adverse effects of older blood.

"The biggest impact of a paper like this is that it is really a call to arms, coming from a well-established institute with some of the best cardiac surgery in the world," Rao said.

The Duke studies have shown that "blood undergoes changes profoundly, even in the first 24 hours," Rao said. The major effect is loss of nitric oxide, "which is really fundamental to the process of oxygen exchange," he said.

The Duke researchers are trying to get funding for a study in which nitric oxide would be added to transfused blood, to see whether that offers benefits over the long run, he said. "It needs to be tested in studies long enough to improve survival and outcome," Rao said.

While the various studies are considered and conducted, practical steps can be taken to reduce the need for transfusions, Koch said. Patients should be tested before surgery to determine if their hematocrit -- a measure of possible anemia -- is low enough to cause worry. "If there is anemia, you should find the source of it and treat it," she said.

The Cleveland Clinic is also using medication that decreases bleeding, and even gathers red cells that are washed and restored to the patient's body, she said.

More information

To learn more about transfusions and blood donations, visit the U.S. National Library of Medicine.



SOURCES: Colleen Gorman Koch, M.D., Cleveland Clinic department of cardiothoracic anesthesia; Sunil Rao, M.D., assistant professor of medicine, Duke University Medical Center; March 20, 2008, New England Journal of Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Children with sickle cell disease, silent strokes show some relief with blood transfusions
2. Study links blood transfusions to surgery complications in women
3. Controversial Anemia Drug Doesnt Cut Need for Transfusions
4. New Brain Fitness Training Promotes Health and Independence of Long Term Care Insurance Policyholders
5. Broad Stakeholder Coalition Concludes that the Pathway for Biosimilars Act Fails to Ensure Timely Access to Safe, Affordable Biogeneric Medicines for Patients
6. Rate of escalator injuries to older adults has doubled
7. Aspirin Reduces Asthma Risk Among Older Women
8. New World Record Holder in Powerlifting Credits NutraCeas Unique Rice-Bran-derived Product as his Secret Weapon
9. Teenage girls arent the only ones who tan indoors -- older adults do so as well
10. Older Men With Low Testosterone Face Greater Depression Risk
11. Governor Rendell Proclaims Older Pennsylvanians Nutrition Awareness Week
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Transfusions of 'Older' Blood Don't Work as Well
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
Breaking Medicine Technology: