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Transfusing Anemic Cancer Patients Boosts Clot Risk
Date:11/28/2008

But the danger is about the same as using drugs for treatment, study suggests

FRIDAY, Nov. 28 (HealthDay News) -- Giving blood transfusions to treat anemia in cancer patients increases the risk of potentially lethal blood clots, say University of Rochester, N.Y., researchers.

But this risk is no greater than other treatments for cancer treatment-related anemia, the scientists said, after having analyzed data on more than 70,500 cancer patients who received transfusions at 60 medical centers from 1995 to 2003.

Of those patients, 7.2 percent developed venous thromboembolism (VTE), and 5.2 percent developed arterial thromboembolism (ATE), compared with rates of 3.8 percent and 3.1 percent, respectively, among patients who didn't receive transfusions.

The study was published in the latest issue of the journal Archives of Internal Medicine.

Anemia is a common side effect of chemotherapy. Red blood cell-boosting drugs called erythropoiesis-stimulating agents (ESAs) are used to fight anemia, but these medications increase the risk of blood clots, and the U.S. Food and Drug Administration last year issued restrictions on their use. It was hoped that red blood cell transfusions would offer a safe alternative.

While blood transfusion did increase the risk of blood clots, the risk is comparable to that of ESAs.

The researchers said their findings pose a dilemma for doctors who want to prevent blood clots, one of the leading causes of illness and death in cancer patients. Parts of blood clots can break off and travel to other parts of the body, causing a serious problem in the lungs (pulmonary embolism) or a heart attack or stroke.

"We've known that medications used for the treatment of anemia in cancer cause blood clots, and using transfusions was an alternative that some doctors chose to try to avoid this problem, lead author Dr. Alok Khorana said in a university news release
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