Navigation Links
Transforming scar tissue into beating hearts: The next instalment
Date:4/1/2012

ut" in animal models, they disrupted normal formation of the heart.

In the 2010 Cell paper, working in a Petri dish, the team were able to identify three of these genes Gata4, Mef2c, and Tbx5 that could convert fibroblasts taken from the hearts of adult mice into new myocytes. "By removing each gene one at a time we were able to whittle things down to the three factors that were indispensible," explained Srivastava.

In the second part of the study, the team injected fibroblasts that already had the three genes inserted directly into the scar tissue of mice. They were able to show the fibroblasts differentiated into cardiomyocyte-like cells.

"The fibroblasts converted into cells with nice patterns of striations, typical of myocytes, and developed units that could generate force," he said.

In the latest study (currently in press), Srivastava explained, they have been able to take the process one step further by injecting a viral vector encoding the genes for Gata4, Mef2c, and Tbx5 directly into the scar tissue of mice who had just experienced an MI. "With these studies we've obtained even better results showing that the fibroblasts become more like cardiomyocytes and functionally couple with their neighbours. They could beat in synchrony and improve the function of the heart," he said.

The team have also shown that fibroblasts taken from the skin of mice (dermal fibroblasts) can be converted into muscle-like cells. "Such data suggests fibroblasts throughout the body have the potential to be transformed, which means that similar approaches, using different factors, could be used to regenerate nerve cells for patients with spinal cord injuries and other cells for diabetic patients," said Srivastava.

For MI treatment, said Srivastava, the next step will be to test the direct injection approach in a larger animal, such as a pig, whose hearts are similar in size to humans. But a big question remains w
'/>"/>

Contact: ESC Press Office
press@escardio.org
33-049-294-8627
European Society of Cardiology
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Palliative Care: Transforming the Care of Serious Illness
2. National committee releases findings on transforming and improving the nursing profession
3. Transforming medical implants
4. New study suggests stem cells sabotage their own DNA to produce new tissues
5. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
6. Step Up to Speak Up Events Use Spoken Word and African-American Greek Tradition of Stepping to Raise Awareness for Organ and Tissue Donation
7. CSMG Technologies, Inc. Engages New Team to Manage Live Tissue Connect, Inc.
8. Paired drugs kill precancerous colon polyps, spare normal tissue
9. Tissue engineers create a new way to assemble artificial tissues
10. Ultrasound could boost tissue implant success
11. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... benefit from being prescribed exercise as medicine, according ... high intensity activity is essential to reducing the ... Debra Anderson, from QUT,s Institute of Health and ... treatments for physical and mental health, health professionals ... women. , Professor Anderson and QUT,s Dr Charlotte ...
(Date:7/11/2014)... University has revealed that people who have grown up ... likely as their urban counterparts to develop the most ... The study findings have recently been published in the ... extremely exciting that we can now see that not ... appear to depend on the environment we are exposed ...
(Date:7/11/2014)... Emily Johnson, owner of the Portland Fit Body Boot Camp, ... has held two charity workout events and is about to ... 7:15 - 8:30 at Col Summers City Park, SE 20th and ... raised $510 for Medical Teams International. Their second workout event resulted ... On July 26th, Johnson and Portland Fit Body Boot Camp ...
(Date:7/11/2014)... Recently, iFitDress.com, a leading online supplier of wedding ... new collection of evening dresses for 2014. ... all these beautiful items are provided with big discounts, ... offer is July 22. , According to the ... to customer satisfaction. On the company’s website, sincere customer ...
(Date:7/11/2014)... 11, 2014 H.E.A.R Me Out Listens ... launches this week to provide comprehensive information and services ... half a million Coloradoans with hearing loss, this organization ... encompassing information of the local and state resources that ... hearing impaired. , H.E.A.R. Me Out and its website ...
Breaking Medicine News(10 mins):Health News:Exercise is the best medicine: QUT study 2Health News:Growing up on a livestock farm halves the risk of inflammatory bowel diseases 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 3Health News:Worldwide Chic Ladies Can Buy Cheap Evening Dresses at iFitDress.com 2Health News:H.E.A.R Me Out Listens to Needs of Hearing Impaired 2Health News:H.E.A.R Me Out Listens to Needs of Hearing Impaired 3
... CREEK, Mich., April 8, 2008 Diplomat ... the company as Director of,National Accounts. Maynard ... of Managed Markets., Maynard is responsible ... disease management programs, focusing initially on chronic,kidney ...
... Ill., April 8, 2008 The Northern Illinois,Fire Sprinkler ... a fire from spreading in a multi-unit building last ... the Chicago area., According to the Lake Zurich ... in a cardboard box where oily rags,thinner and paintbrushes ...
... rate when moms-to-be work out regularly , , TUESDAY, April 8 ... when the one exercising is a pregnant woman. , A ... reaps cardiac benefits. The benefits show up as lower fetal heart ... at the Experimental Biology 2008 annual meeting in San Diego. , ...
... who receive microwave therapy for enlarged prostates experience significant ... of a heart attack or stroke, according to new ... The Mayo Clinic-led study of 185 consecutive patients who ... that 42 percent experienced systolic blood pressure surges of ...
... in the most serious healthcare settings, even when patients are ... in the April issue of the UK-based Journal of Clinical ... and carrying out interviews with staff, patients and families in ... people with terminal illnesses. , They concluded that ...
... Board: CLAI), a leading provider of electronic transaction,services ... have signed,an agreement with Aetna to provide electronic ... Claimsnet will deliver claims,and receive Electronic Remittance Advice ... healthcare providers., "Claimsnet is extremely pleased to ...
Cached Medicine News:Health News:Diplomat Specialty Pharmacy Hires National Accounts Director To Expand Kidney Disease Services 2Health News:Fire Sprinklers Prevented More Than a Dozen Major Fires This Year in Chicago Area 2Health News:Microwave treatments for enlarged prostate cause blood pressure surges 2Health News:Humor plays an important role in healthcare even when patients are terminally ill 2Health News:Humor plays an important role in healthcare even when patients are terminally ill 3Health News:Claimsnet Announces Agreement With Aetna for Electronic Claims and Remittance Processing 2
(Date:7/11/2014)... According to a new market ... (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) - Global ... the global endoscopy devices market was valued at USD ... at a CAGR of 6.8% from 2013 to 2019, ... in 2019. Browse the full Endoscopy Devices Market ...
(Date:7/11/2014)... 11, 2014 Neurelis, Inc. ("Neurelis") today announced ... the option held by Biotie to purchase Neurelis, clearing ... NRL-1 (intranasal diazepam) for pediatric and adult epilepsy patients ... past year, Biotie has advanced the development program for ... pivotal clinical work required for NDA submission to the ...
(Date:7/10/2014)... CARLSBAD, Calif. , July 10, 2014 /PRNewswire/ ... products and services, has launched the FreeRunner™ knee ... runners, who suffer from patella mal-tracking return to ... anatomy differently than other braces, providing support when ... move normally when they don,t. Patellofemoral ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2
... Kendle (Nasdaq: KNDL ), a leading, global full-service clinical research organization, today ... on June 23, 2010 , at the InterContinental Hotel in Boston . ... Kendle,s formal presentation will be given by Chairman ... Time . , , , ...
... June 17 Brainlab AG today announced that it ... business unit of the Toshiba Group, to integrate its Aquilion™ LB ... operating room (OR). , , ... Stephan Holl , Chief Operating Officer, Brainlab, indicated that ...
Cached Medicine Technology:Kendle to Present at 2010 Wells Fargo Securities Healthcare Conference 2Brainlab Collaborates With Toshiba Medical Systems on Integrated Surgical Suite 2Brainlab Collaborates With Toshiba Medical Systems on Integrated Surgical Suite 3
... The NMP22® Test Kit is a quantitative ... NMP22 protein. Healthy individuals generally have very small ... the level of NMP22 protein is often elevated ... even at early stages of the disease. The ...
... connect an infusion bag ... and then to a ... to conduct urodynamics studies. ... Medical Technologies infusion pumps. ...
Used for cystometry and urethral pressure profilometry. A loop is employed to enhance catheter retention and stabilization within the bladder. Supplied sterile in peel-open packages. Intended for one...
... Used for cystometry and urethral pressure ... for faster filling of the bladder ... Dual lumen catheter construction allows the ... is performed. Triple lumen catheter construction ...
Medicine Products: