Navigation Links
Transcription factors may dictate differences between individuals
Date:3/18/2010

Researchers are only beginning to understand how individual variation in gene regulation can have a lasting impact on one's health and susceptibility to certain diseases. Now, an ambitious survey of the human genome has identified differences in the binding of master regulators called transcription factors to DNA that affect how genes are expressed in different people.

The study, which is published in the March 18, 2010, issue of Science, looked at two common transcription factors. HHMI medical research fellow Maya Kasowski and her colleagues in the laboratory of molecular biologist Michael Snyder at Yale University conducted the work with Jan Korbel at the European Molecular Biology Laboratory. Snyder has since joined the faculty at Stanford University.

Transcription factors account for as much as 10 percent of the coding genome in humans and other organisms. When activated, transcription factors switch on or off hundreds or thousands of genes, a cascade that programs cells to grow or divide. "The activity of transcription factors determines what a cell is doing at any given moment," says Kasowski, who was a medical student at Yale when she received her HHMI medical research fellowship. She has since decided to pursue an M.D./Ph.D. degree.

Despite their large numbers and critical role, many aspects of transcription factor biology remain poorly understood. Until now, no one had looked at whether there was any variability in the targets of transcription factors from one person to the next. The current study found a "number of differences between individuals" in the binding sites of two transcription factors, Snyder says.

Transcription factors bind to the human genome within areas of the genome still viewed as a black boxvast stretches of DNA sequence between known genes. Gradually, biologists have found that much of this DNA performs a vital functionhelping turn genes on and off in specific situations. Some of the r
'/>"/>

Contact: Andrea Widener
widenera@hhmi.org
301-215-8807
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Medical Transcription Services and EHR Provider MxSecure Promotes Tim Erkel to VP, Client Services
2. Update: MedQuist Wins Contract with Detroit Medical Center for Emergency Medicine Transcription at Six Healthcare Organizations
3. MedQuist Wins Contract with Detroit Medical Center for Emergency Medicine Transcription at Six Healthcare Organizations
4. Medical Transcription Services and EHR Provider MxSecure Launches New Enhanced Website with Goal of Improved Physician Productivity
5. VIVA Transcription Engages Satrix Solutions to Develop Customer Feedback Programs
6. Webmedx Announces #1 Ranking in KLAS 2009 Transcription Services Report
7. Medical and Legal Professionals Find Relief Leveraging Apple iPhone App for Dictation and Transcription 'On the Go'
8. Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
9. Randy Olver Named Emdat CEO, Will Lead Next Phase of Growth for Medical Transcription Solutions Provider
10. Medical Transcription Service Provider, MxSecure, Teams with HealthCare Partners/PACIS to Accelerate Physician EHR Adoption
11. AHDI 2009 President, Susan Lucci, Joins 4th Largest Medical Transcription Company, Webmedx
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... HORAN, a leading advisor in employee ... Carl as Vice President – Retirement Services. , Paul ... retirement planning. In addition, he monitors investments, fees and ... Paul has been a retirement services industry professional for ... as a Senior Investigator at the Department of Labor ...
(Date:9/16/2014)... London, UK (PRWEB) September 16, 2014 ... paediatric clinical trials has risen considerably in line with ... USA, over 350 product labels include novel paediatric information ... safety review. In the European countries, there has been ... medicinal products from the submission of old or new ...
(Date:9/16/2014)... Atlanta, GA (PRWEB) September 16, 2014 ... New York Automobile Dealers Association’s newly elected chairman, Robert ... discusses his association’s plans to further the causes of ... also stories from some of the retail automotive industry’s ... Equifax, who explains why it’s important to take a ...
(Date:9/16/2014)... CITY, CALIF. (PRWEB) September 16, 2014 ... center and customer service solutions, announced today that ... Excellence in Learning Award for the creation of ... independent contractor agents. Brandon Hall Group honors companies ... modalities, processes, systems and tools that have helped ...
(Date:9/16/2014)... NJ (PRWEB) September 16, 2014 ... leading Bariatric Surgeon, Leigh Montes, MD, has joined ... Surgery at Christ Hospital. Our system welcomes Dr. ... a medical and surgical weight loss center, helps ... most advanced bariatric surgery procedures, including Gastric Sleeve, ...
Breaking Medicine News(10 mins):Health News:Paul Carl Joins HORAN's Retirement Plan Consulting Organization 2Health News:Paediatric Drug Development Market Analysed by CBR Pharma Insights in In-demand Report Available at MarketPublishers.com 2Health News:Paediatric Drug Development Market Analysed by CBR Pharma Insights in In-demand Report Available at MarketPublishers.com 3Health News:September Issue of Car Biz Today Magazine Available Online 2Health News:LiveOps Wins Silver At The 2014 Brandon Hall Group Excellence In Learning Awards For Best Use Of Social/Collaborative Learning 2Health News:LiveOps Wins Silver At The 2014 Brandon Hall Group Excellence In Learning Awards For Best Use Of Social/Collaborative Learning 3Health News:LiveOps Wins Silver At The 2014 Brandon Hall Group Excellence In Learning Awards For Best Use Of Social/Collaborative Learning 4Health News:Top Bariatric Surgeon Joins CarePoint Health 2Health News:Top Bariatric Surgeon Joins CarePoint Health 3
... ... Leading Physicians of the World has now made their elite group of physicians accessible online. ... put themselves in the hands of an expert physician for their next visit., , ... New York, NY (PRWEB) March 23, ...
... , President & CEO of Medicaid Health Plans of America (MHPA), the leading trade association solely focused on representing Medicaid health plans, issued the following statement after the House ... ... ... ...
... National Alliance on Mental Illness ( NAMI ) has launched StrengthofUs.org , a new online community where young adults living with mental ... ... , , ... ...
... Lindt Chocolate , the world,s leading producer of premium chocolate, today announces the 2010 Lindt Unsung Heroes of Autism . ... affected by autism in their families, homes and communities.   , ... ... ...
... , March 23 Connectyx Technologies Holdings Group, ...  has appointed Dr. James R. Taylor to its ... healthcare and pharmaceutical field. He has written several publications; in ... elite institutions, such as the University of Florida , ...
... ... , ... ... ATLANTA , March 23 Radiotherapy Centers of Georgia (RCOG), a division of RC Cancer Centers announced today ...
Cached Medicine News:Health News:Findatopdoc.com Uses Cutting Edge Technology in Bringing the Leading Physicians of the World Directly to Your Computer For Consumers to Find a Top Doctor 2Health News:MHPA Statement on Health Reform Legislation 2Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 2Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 3Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 4Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 5Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 6Health News:NAMI Launches Social Networking Site for Young Adults: Mental Health, Finances, Relationships, Music and More 7Health News:Lindt USA Announces 'Lindt Unsung Heroes of Autism' 2Health News:Lindt USA Announces 'Lindt Unsung Heroes of Autism' 3Health News:Lindt USA Announces 'Lindt Unsung Heroes of Autism' 4Health News:Lindt USA Announces 'Lindt Unsung Heroes of Autism' 5Health News:Lindt USA Announces 'Lindt Unsung Heroes of Autism' 6Health News:Connectyx Technologies Holdings Group, Inc. Appoints Dr. James R. Taylor to Its Board of Advisors 2Health News:Connectyx Technologies Holdings Group, Inc. Appoints Dr. James R. Taylor to Its Board of Advisors 3Health News:Connectyx Technologies Holdings Group, Inc. Appoints Dr. James R. Taylor to Its Board of Advisors 4Health News:Connectyx Technologies Holdings Group, Inc. Appoints Dr. James R. Taylor to Its Board of Advisors 5Health News:Prostate Cancer Treatment Database Hits Milestone of 12,500 2Health News:Prostate Cancer Treatment Database Hits Milestone of 12,500 3Health News:Prostate Cancer Treatment Database Hits Milestone of 12,500 4Health News:Prostate Cancer Treatment Database Hits Milestone of 12,500 5
(Date:9/16/2014)... LONDON , Sept. 16, 2014 ... wound closure market, Frost & Sullivan recognises Incisive ... Award for Customer Value Leadership. Incisive Surgical,s uniquely-designed, ... closure technology that eliminates the need for patients ... punctures and staple removal  that may result in ...
(Date:9/16/2014)... Sept. 16, 2014  Synereca Pharmaceutics, Inc. ... orally active drugs that restore or increase ... a $1.4 million convertible debt financing. Accele ... sciences accelerator Accele Biopharma, Inc., led the ... nationally recognized private not-for-profit corporation focused on ...
(Date:9/16/2014)... Sept. 16, 2014  Relmada Therapeutics, Inc., (OTCBB: RLMD), ... of chronic pain, announced today that it has entered ... (MSKCC) in a series of animal studies for levorphanol, ... extended release form of levorphanol.  Gavril Pasternak, MD, PhD, ... Dr. Pasternak said, "Levorphanol is a ...
Breaking Medicine Technology:Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 2Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 3Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 4Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 5Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 2Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 3Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 4Relmada Therapeutics Enters Into Agreement with Memorial Sloan Kettering to Better Clarify Unique Mechanism of Action for LevoCap ER 2Relmada Therapeutics Enters Into Agreement with Memorial Sloan Kettering to Better Clarify Unique Mechanism of Action for LevoCap ER 3
... Study Success in Using Virus Enzyme to Treat Mouse ... Be Used to,Prevent Both Ear Infection and Pneumonia in ... -- Parents might one,day give their children a weekly ... them from getting a severe middle ear,infection, based on ...
... the Drug Improves Memory, SARASOTA, Fla., March 22, ... it has received positive,preliminary results in its major ... application for the treatment of Alzheimer's,disease. The clinical ... first human clinical study conducted by a,Florida-based research ...
Cached Medicine Technology:Viral Enzyme Recruited in Fight Against Ear Infection 2Viral Enzyme Recruited in Fight Against Ear Infection 3Sarasota's Roskamp Institute Announces Positive Safety Data in,Human Clinical Study for Alzheimer's Disease 2
BD Vacutainer® PST™ Tubes contain spray-coated lithium heparin and a gel for plasma separation. They are used for plasma determinations in chemistry....
The Erythrocyte Sedimentation Rate (ESR) can be used as a nonspecific search technique in case of suspicion of inflammatory reactions as well as for judgement of their development. VACUETTE ESR tubes...
VACUETTE paediatric tubes have decreased sample volumes and are ideal for small childrens' veins and geriatric patients....
Glucose tubes contain an anti-coagulant and a stabiliser. The tubes are ideal for glucose and lactate determinations....
Medicine Products: