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Transcept Pharmaceuticals Presents Data from Studies of Two Product Candidates at Annual Meeting of the American Psychiatric Association
Date:5/21/2009

The 3.5 mg zolpidem tartrate sublingual tablet was well tolerated and no safety issues were identified.

The second poster, titled "Ondansetron Augmentation in Treatment Resistant OCD: A Preliminary Single-Blind Prospective Study," was presented on May 20, 2009 by Eric Hollander, M.D., Director, Neuropharmacology Services, LLC and former Esther and Joseph Klingenstein Professor and Chair of Psychiatry at the Mount Sinai School of Medicine. The pilot study, which involved 14 patients with a DSM-IV diagnosis of treatment resistant obsessive compulsive disorder (OCD) and under stable treatment with selective serotonin reuptake inhibitors (SSRIs) and neuroleptic augmentation, aimed to evaluate the potential of ondansetron augmentation as an alternative treatment for OCD.

Following a 12-week single blind trial of ondansetron initiated at a dose of 0.25 mg twice daily for six weeks, and titrated to 0.5 mg twice daily for six weeks, results demonstrated that nine of 14 subjects (65 percent) experienced a treatment response at 12 weeks based on a score of greater than or equal to 25 percent reduction in the Yale Brown Obsessive Compulsive Scale (YBOCS). The average reduction in YBOCS-rated symptoms of the whole group was 23.2 percent. According to the researchers, the results suggested that low-dose ondansetron may have promise as an alternative treatment strategy for some patients suffering from OCD resistant to SSRIs and antipsychotic augmentation. None of the treated patients experienced symptom exacerbation or significant side effects.

Glenn Oclassen, President and Chief Executive Officer of Transcept Pharmaceuticals, commented, "The posters presented by Dr. Rosenberg and Dr. Hollander lend further support to the Transcept strategy of deriving significant new patient benefits from proven drugs to address significant unmet medical needs. We are honored to have the opportunity to collaborate with such renowned resea
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SOURCE Transcept Pharmaceuticals, Inc.
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