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Transcatheter aortic valve implantation with the Edwards valve prosthesis in patients with low
Date:8/30/2011

Results from a study presented today at the ESC Congress 2011, show that TAVI implantation in low risk patients, met with 100% procedural success (versus 95.3% in the high Euroscore group (p=0.1).

"The most interesting point to observe is the absence of death at one month in the low Euroscore group, versus a mortality rate of 11.1% in the high Euroscore group (>20%), (p < 0.04) and this result is confirmed at 1-year with 5 vs 24.8 %, (p<0.01). While we were expecting a lower mortality among patients with low Euroscore, the observed difference was much greater than anticipated. In fact the mortality rates have approached the results with conventional surgery," explained Dr Matthieu GODIN, from the University Hospital of Rouen, France.

Aortic stenosis is the most frequently acquired valve disease in adults. 2% are symptomatic and thus should require aortic valve replacement because, in this disease, a long latency is followed by rapid progression after the appearance of symptoms, with more than half of patients dying within two years. It can be estimated that with the aging population, within 15 years, the number of aortic stenosis patients will double.

After more than 15 years of research, the first-in-man percutaneous valve implantation was performed in our center at the University Hospital of Rouen by Prof. Cribier in April 2002. Since then, about 40 000 patients have been implanted worldwide with the use of two different models of valve: the balloon expandable valve 1 and the self expanding device 2. The CE mark was obtained for both in 2007. TAVI can today be proposed as an alternative treatment and has recently demonstrated its great efficiency with the results of the pivotal PARNER-US trial.

Based on the recommendations of both the European Society of Cardiology and the European Society of Cardiac Surgery, most of the registries have so far only included patients with high logistic Euroscore > 20%. (a system deve
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Contact: Jacqueline Partarrieu
press@escardio.org
33-633-473-335
European Society of Cardiology
Source:Eurekalert

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