Navigation Links
Transcatheter aortic valve implantation with the Edwards valve prosthesis in patients with low
Date:8/30/2011

Results from a study presented today at the ESC Congress 2011, show that TAVI implantation in low risk patients, met with 100% procedural success (versus 95.3% in the high Euroscore group (p=0.1).

"The most interesting point to observe is the absence of death at one month in the low Euroscore group, versus a mortality rate of 11.1% in the high Euroscore group (>20%), (p < 0.04) and this result is confirmed at 1-year with 5 vs 24.8 %, (p<0.01). While we were expecting a lower mortality among patients with low Euroscore, the observed difference was much greater than anticipated. In fact the mortality rates have approached the results with conventional surgery," explained Dr Matthieu GODIN, from the University Hospital of Rouen, France.

Aortic stenosis is the most frequently acquired valve disease in adults. 2% are symptomatic and thus should require aortic valve replacement because, in this disease, a long latency is followed by rapid progression after the appearance of symptoms, with more than half of patients dying within two years. It can be estimated that with the aging population, within 15 years, the number of aortic stenosis patients will double.

After more than 15 years of research, the first-in-man percutaneous valve implantation was performed in our center at the University Hospital of Rouen by Prof. Cribier in April 2002. Since then, about 40 000 patients have been implanted worldwide with the use of two different models of valve: the balloon expandable valve 1 and the self expanding device 2. The CE mark was obtained for both in 2007. TAVI can today be proposed as an alternative treatment and has recently demonstrated its great efficiency with the results of the pivotal PARNER-US trial.

Based on the recommendations of both the European Society of Cardiology and the European Society of Cardiac Surgery, most of the registries have so far only included patients with high logistic Euroscore > 20%. (a system developed to predict the operative mortality of coronary surgery).

In view of the overall good results in this high risk population, a significant trend to include lower risk patients in Europe has been observed. The last registries have seen their Euroscore decreasing to 15% and some prospective trials are planned to include patients whatever their Score.

"We sought to evaluate the results obtained in our subgroup of patients with a low Euroscore. It does not mean that the patients were at very low risk for TAVI, since they had been considered as having surgical contraindication which did not affect the Euroscore (radiotherapy, corticosteroids, thoracic deformation or porcelain aorta). However, the patients were often less sick and younger and it seemed interesting to assess the results in this population," said Dr Godin.

This study is a retrospective study from all 177 patients implanted with the Edwards prosthesis at the Rouen centre between May 2006 and January 2011. Patients were divided into two groups according to their predictive Logistic Euroscore: High Euroscore (>20%) vs Low Euroscore (<20%).

Results show that procedural success was 100% in the low Euroscore group versus 95.3% in the high Euroscore group (p=0.1).

The most interesting point to observe is the absence of death at one month in the low Euroscore group, versus a mortality rate of 11.1% in the high Euroscore group (>20%), (p < 0.04) and this result is confirmed at 1-year with 5 vs 24.8 %, (p<0.01)

While we were expecting a lower mortality among patients with low Euroscore, the observed difference was much greater than anticipated. In fact the mortality rates have approached the results with conventional surgery.

The results represent a first step towards a broader assessment of percutaneous techniques in populations at lower surgical risk but without forgetting that surgery is currently the gold standard


'/>"/>

Contact: Jacqueline Partarrieu
press@escardio.org
33-633-473-335
European Society of Cardiology
Source:Eurekalert

Related medicine news :

1. Press registration now open for Transcatheter Valve Therapies
2. Early transcatheter valve recipient honored with Courageous Patient Award at TCT 2010
3. Simple new bedside screening effectively identifies patients with acute aortic dissection
4. University of Michigan Cardiovascular Center studies new treatment for high-risk aortic patients
5. Mount Sinai first in US to implant aortic valve prosthesis to treat severe aortic stenosis
6. Aortic aneurysm treatable with asthma drugs
7. Clinical trial establishes catheter-based aortic valve replacement as new standard of care
8. New treatment for severe aortic stenosis shown to save lives, Stanford researchers say
9. New Procedure for Aortic Valve Replacement Looks Promising
10. Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
11. Regional protocols improve quality of care for aortic dissection patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Rob Lowe is a sought after ... Public Television. “Informed” brings the public important topics from all aspects of life, and ... feet and issues surrounding feet and ankles. , Podiatry is essential to people’s overall ...
(Date:5/24/2017)... , ... May 24, 2017 , ... Technique, technique, technique ... injury when either lifting weights for strength training and exercise or simply lifting heavy ... . , “Body position is everything,” Dr. Chang says. “Improper technique in lifting anything ...
(Date:5/23/2017)... ... ... Axiad IDS , a leading provider of trusted identities for enterprise, ... a “Top 25 Cybersecurity Companies 2017.” Axiad IDS received this honor in ... address potential cybersecurity threats before they happen. The annual list of top ...
(Date:5/23/2017)... ... 2017 , ... Cambridge, MA, May 23, 2017—Total costs per ... a Workers Compensation Research Institute (WCRI) study, a contrast from the increases of ... Benchmarks, 17th Edition looks at indemnity and medical payments for workers’ compensation ...
(Date:5/23/2017)... ... May 23, 2017 , ... The National Council ... pleased to announce the organization’s Certified Strength Coach credential has earned accreditation from ... (CSC) program validates the competency of qualified candidates for jobs in the Strength ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... WAYNE, Pa. , May 4, 2017 /PRNewswire/ ... made from thermoplastics and other highly-engineered materials, is ... Microextrusion tubing has been developed in recent ... neurovascular interventional therapies and surgical applications. More expensive ... used to produce microextrusion tubing due to their ...
(Date:5/3/2017)... May 3, 2017  Kalorama Information notes that ... percent next year and this is projected to ... stem cell (HSCT) or bone marrow transplants require ... are well-suited for this task. This according to ... Kalorama Information. The various PCR-based methodologies, Sanger sequencing ...
(Date:5/2/2017)... YORK and LONDON , ... of market intelligence, MarketResearch.com is pleased to announce a ... AB that allows for the marketing and distribution ... analyses through the MarketResearch.com website. The new ... to complete product descriptions and tables of contents from ...
Breaking Medicine Technology: