Philadelphia, Pa, 27 January 2010 - The growing numbers of new cases of substance abuse disorders are perplexing. After all, the course of drug addiction so often ends badly. The negative consequences of drug abuse appear regularly on TV, from stories of celebrities behaving in socially inappropriate and self-destructive ways while intoxicated to dramatization of the rigors of drug withdrawal on "Intervention" and other reality shows.
Schools now educate students about the risks of addiction. While having a keen awareness of the negative long-term repercussions of substance use protects some people from developing addictions, others remain vulnerable.
One reason that education alone cannot prevent substance abuse is that people who are vulnerable to developing substance abuse disorders tend to exhibit a trait called "delay discounting", which is the tendency to devalue rewards and punishments that occur in the future. Delay discounting may be paralleled by "reward myopia", a tendency to opt for immediately rewarding stimuli, like drugs.
Thus, people vulnerable to addiction who know that drugs are harmful in the long run tend to devalue this information and to instead be drawn to the immediately rewarding effects of drugs.
Delay discounting is a cognitive function that involves circuits including the frontal cortex. It builds upon working memory, the brain's "scratchpad", i.e., a system for temporarily storing and managing information reasoning to guide behavior.
In a new article in Biological Psychiatry that studied this process, Warren Bickel and colleagues used an approach borrowed from the rehabilitation of individuals who have suffered a stroke or a traumatic brain injury. They had stimulant abusers repeatedly perform a working memory task, "exercising" their brains in a way that promoted the functional enhancement of the underlying cognitive circuits.
They found that this type of training improved working memory and
|Contact: Chris Pfister|