Navigation Links
Traffic Fumes Plus Genes Boosts Kids' Asthma Risk
Date:8/22/2007

Study finds some children are more vulnerable

WEDNESDAY, Aug. 22 (HealthDay News) -- Traffic pollution raises asthma risk in children who are already genetically susceptible to the disease, according to a new study of more than 3,000 asthmatic children.

According to a team at the University of Southern California Keck School of Medicine, Los Angeles, prior research had spotted variations in genes that control enzymes responsible for clearing harmful chemicals breathed into the body. These gene variants have also been linked to the development of asthma and other respiratory diseases.

In this new study, researchers analyzed the children's microsomal epoxide hydrolase (EPHX1) levels and genetic variations in gluathione S-transferase P1 (GSTP1) -- enzymes that help rid the body of toxins, including polyaromatic hydrocarbons from vehicle exhaust.

Overall, children with very active EPHX1 were 1.5 times more likely to have asthma as children with low EPHX1 activity, and those who had high EPHX1 activity and a variation in the GSTP1 gene were four times more likely to have asthma.

The researchers also found that exposure to traffic pollution was a major factor in triggering genetic susceptibility to asthma.

Children with very active EPHX1 who lived within 75 meters of a main road were more than three times as likely to have asthma as those with low EPHX1 levels. But children with one or two variations in the GSTP1 gene who lived close to a major road were up to nine times more likely to have asthma than children who lived farther away from a major road.

Children with high EPHX1 activity who have genetic variants of GSTP1 have an increased risk of developing asthma, the researchers said, and the risk is even greater among those who are exposed to traffic pollution.

The study is published in the journal Thorax.

More information

The American Lung Association has more about childhood asthma.



-- Robert Preidt



SOURCE: BMJ Specialist Journals, news release, Aug. 21, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Traffic Violations Result in Safer Drivers
2. Drug trafficking via Internet a growing threat
3. Traffic pollution linked to severe asthma attacks
4. Traffic Smoke May Damage DNA
5. HIV Infection Higher In Drug Trafficking Countries
6. Alcohol And Drug Abuse (Cannabis) Leading Causes For Road Traffic Accidents
7. Trafficking of Women from Asia and East Europe For Flesh Trade
8. Travel And Tourism Industry Calls For Global Efforts To Limit Sexual Trafficking Of Children
9. Asthma Risk Pronounced In Children Living Close to Traffic Ridden Roads
10. Striking Doctors Form Human Chain, Block Traffic
11. Road Traffic Accidents Kill 4,000 people in Delhi
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... , ... Only two months after the official release of The Private Collection ... XO Private has initiated a second print-run of its lavish luxury travel coffee table ... when open, weighs in at more than six kilos, retails at EUR 1,000 per ...
(Date:2/24/2017)... ... 2017 , ... The Smart Machine Age is here, and it’s disrupting everything. ... of all jobs in the United States may be taken over by technology in ... aggressive know-it-all who steamrolls over colleagues is drawing to a close. Success will belong ...
(Date:2/24/2017)... ... February 24, 2017 , ... The narrative in “ Signal 8: ... ’s true account of his paramedic experiences. Schanssema describes the tragedies he saw, as ... attempts to overcome them. , Schanssema, initially unsure of the career path he wanted ...
(Date:2/24/2017)... ... ... The International Association of Eating Disorders Professionals (iaedp) announces the 2017 top five ... art competition. Selected from 15 submissions from around the nation, the top five finalists ... iaedp Symposium, March 22 – 26 in Las Vegas. , This year, the competition ...
(Date:2/24/2017)... , ... February 24, 2017 , ... ... into the Senior International Elite division on February 12th. Ms. Esparza qualified ... at the elite qualifier competition held in Las Vegas, Nevada. Frida is one ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Research and Markets has announced the addition of the "Urinary ... their offering. ... The latest research Urinary Incontinence Drugs Price Analysis and Strategies - ... Incontinence market. The research answers the following questions: ... Incontinence and their clinical attributes? How are they positioned in the ...
(Date:2/23/2017)... , Südkorea, 23. Februar 2017 LG ... für Sterilisationsaufgaben vorgestellt. Die Sterilisationsleistung beträgt das 1,5-fache des ... ultraviolette Strahlung im Bereich zwischen 200 und 280 nm und ... von Bakterien, indem es ihre DNA zerstört. Das Produkt ... ...
(Date:2/23/2017)... -- Research and Markets has announced the addition of the ... their offering. ... research Menopause Drugs Price Analysis and Strategies - 2016, provides drug pricing ... the following questions: What are the key ... in the Global Menopause market? What are the unit ...
Breaking Medicine Technology: