Navigation Links
Traditional herbal medicine kills pancreatic cancer cells, Jefferson researchers report
Date:5/19/2008

(PHILADELPHIA) An herb used in traditional medicine by many Middle Eastern countries may help in the fight against pancreatic cancer, one of the most difficult cancers to treat. Researchers at the Kimmel Cancer at Jefferson in Philadelphia have found that thymoquinone, an extract of nigella sativa seed oil, blocked pancreatic cancer cell growth and killed the cells by enhancing the process of programmed cell death.

While the studies are in the early stages, the findings suggest that thymoquinone could eventually have some use as a preventative strategy in patients who have gone through surgery and chemotherapy or in individuals who are at a high risk of developing cancer.

According to Hwyda Arafat, M.D., Ph.D., associate professor of Surgery at Jefferson Medical College of Thomas Jefferson University, nigella sativa helps treat a broad array of diseases, including some immune and inflammatory disorders. Previous studies also have shown anticancer activity in prostate and colon cancers, as well as antioxidant and anti-inflammatory effects.

Using a human pancreatic cancer cell line, she and her team found that adding thymoquinone killed approximately 80 percent of the cancer cells. They demonstrated that thymoquinone triggered programmed cell death in the cells, and that a number of important genes, including p53, Bax, bcl-2 and p21, were affected. The researchers found that expression of p53, a tumor suppressor gene, and Bax, a gene that promotes programmed cell death, was increased, while bcl-2, which blocks such cell death, was decreased. The p21 gene, which is involved in the regulation of different phases of the cell cycle, was substantially increased. She presents her findings May 18 at the Digestive Disease Week in San Diego.

Dr. Arafat and her co-workers also found that thymoquinone caused epigenetic changes in pancreatic cancer cells, modifying the cells DNA. She explains that these changes involve adding acetyl
'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Newer Prostate Cancer Treatment Similar to Traditional Surgery
2. Traditional Medicare Benefit Information Soon to be Available Online to Doctors and Hospitals through Blue Cross Blue Shield of Michigan Web Portal
3. PPO Industry Calls for Increased Collaboration Among Non-Traditional Allies
4. Remembering Non-Traditional Moms on Mothers Day
5. Inhaled tuberculosis vaccine more effective than traditional shot
6. Video: New Survey Shows Young Women Turn to Traditional Values in Life, Relationships and Health
7. Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer
8. Wai Wai choose conservation economy for traditional Amazon territory
9. Nurses play a key role in police custody suites, complementing the traditional role of doctors
10. MJGC Hosts Traditional Atonement Services
11. USDA Grants Organic Certification to Ayalas Herbal Water(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... be treated more quickly after Manchester research , ... blood test on arrival, is effective in reducing ... study shows., The findings of a research group ... could potentially make a huge difference to a ... most common reason for emergency hospital admission. In ...
(Date:7/25/2014)... some patients is real and is only natural. However, ... in Cancer , the incidence and effects of ... computed tomography (CT) lung cancer screening exams are far ... , "Unsubstantiated claims of systemic and harmful patient ... continue to delay implementation of CT lung cancer screening ...
(Date:7/25/2014)... Ross A. Clevens, MD, FACS, and ... join the exclusive Obagi Clinical Advisory Board, comprised of ... plastic surgeons and dermatologists. , Dr. Clevens recently ... of thought leaders held its first meeting in three ... give Obagi the opportunity to meet with eight of ...
(Date:7/25/2014)... A report released by the Juvenile Diabetes ... 2013 (July 1, 2012- June 30, 2013). , Outside of ... is the largest single funder of type 1 diabetes research ... with most of the top research centers. There is ... 1 diabetes in the near future. , Since the 2008 ...
(Date:7/25/2014)... HealthDay Reporter , THURSDAY, July ... girls and boys are getting the human papillomavirus (HPV) vaccine, ... officials said Thursday. The U.S. Centers for Disease Control ... 12 get the three-dose vaccine so that protection is in ... Yet, despite a slight increase over the year before, only ...
Breaking Medicine News(10 mins):Health News:Heart attack patients could be treated more quickly after Manchester research 2Health News:ACR statement on cancer study regarding patient anxiety from CT lung cancer screening 2Health News:Renowned Melbourne Plastic Surgeon to Join Private Medical Advisory Board 2Health News:Report: JDRF 2013 Annual Research Spending Down by $50 million 2Health News:Too Few Teens Receive HPV Shot, CDC Says 2Health News:Too Few Teens Receive HPV Shot, CDC Says 3
... outbreaks reported from Vietnam and South Korea has put ... stocked and ready to deal with the situation, if ... Ministry has a stock of 2.5 million capsules of ... doses of influenza vaccines to be given to risk ...
... autoimmune disorder marked by early skin lesions and ... this thickening and hardening of connective tissue affects ... and the heart. In SSc patients, fibrosis frequently ... Researchers have yet to determine the underlying cause ...
... New York: A new study has shown a connection ... breast cancer after menopause//. While there is little doubt that ... seems to be convincing evidence that weight gain in adult ... disease. , ,Yet, not much was known about the ...
... A California based company has developed a pill called Excalia ... researchers working for this announced// the results ... the North American Association for the Study of Obesity.This organisation ... obesity. They claim that this preparation can effectively help ...
... Bharatiya Janta Party has been inspired from the most ... family planning programme for the Muslim community// based on ... and clerics for awareness campaign as well as the ... the way of family planning is ignorance and not ...
... prompt women to both scale back risky drinking and ... ,Prenatal alcohol exposure is a leading preventable cause ... States. This CDC study explored a strategy that could ... ,“A lot of people find this to be ...
Cached Medicine News:Health News:New Treatment Offers Hope for Systemic Sclerosis 2Health News:Madhya Pradesh Imbibes Family Planning Lessons from Pakistan 2Health News:Counseling Helps Young Women Cut Drinking, Improve Contraception Use 2Health News:Counseling Helps Young Women Cut Drinking, Improve Contraception Use 3
(Date:7/24/2014)... -- Uroplasty, Inc. (NASDAQ: UPI ), a medical ... proprietary products to treat voiding dysfunctions, today reported ... ended June 30, 2014.  Global revenue for ... 19% to $4.1 million, as compared to $3.4 ... year.  Total revenue for the fiscal first quarter ...
(Date:7/24/2014)... July 24, 2014  Mettler-Toledo International Inc. (NYSE: ... 2014.  Provided below are the highlights: , ... quarter compared with the prior year. Reported sales increased ... , Net earnings per diluted share as reported (EPS) ... of 2013. Adjusted EPS was $2.57, an increase of ...
(Date:7/24/2014)... 24, 2014 Amgen (NASDAQ: AMGN ) ... results on Tuesday, July 29, 2014, after the close of ... a conference call with the investment community at 2 p.m. ... Robert A. Bradway , chairman and chief executive officer, and ... audio of the conference call will be simultaneously broadcast over ...
Breaking Medicine Technology:Uroplasty Reports Fiscal First Quarter Results 2Uroplasty Reports Fiscal First Quarter Results 3Uroplasty Reports Fiscal First Quarter Results 4Uroplasty Reports Fiscal First Quarter Results 5Uroplasty Reports Fiscal First Quarter Results 6Uroplasty Reports Fiscal First Quarter Results 7Uroplasty Reports Fiscal First Quarter Results 8Uroplasty Reports Fiscal First Quarter Results 9Uroplasty Reports Fiscal First Quarter Results 10Uroplasty Reports Fiscal First Quarter Results 11Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2014 Results 14Amgen Announces Webcast of 2014 Second Quarter Financial Results 2
... March 12 Genta,Incorporated (Nasdaq: GNTA ) today announced ... 31, 2007. The Company noted,significant recent milestones, including:, ... biomarker initiates in melanoma -- New oral product, ... 505(b)(2) strategy -- Tesetaxel, a leading ...
... Achieve Weight Loss with Education & ... ... Findings in the Journal of,the American Medical Association on the largest ... prevention.,The combination of both personal contact and web-based support are,identified as ...
Cached Medicine Technology:Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights 2Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights 3Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights 4Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights 5Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights 6Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights 7Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights 8Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights 9Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights 10Study Finds Personal and Web-Based Support Equal Weight Loss Success 2Study Finds Personal and Web-Based Support Equal Weight Loss Success 3Study Finds Personal and Web-Based Support Equal Weight Loss Success 4
... ophthalmic solution is an anti-infective ... doctor may instruct you to ... eye infection caused by bacteria. ... are the 2 types of ...
ALPHAGAN® (brimonidine tartrate ophthalmic solution) 0.2% is indicated for lowering IOP in patients with open-angle galucoma or ocular hypertension....
ALPHAGAN® P (brimonidine tartrate ophthalmic solution) 0.15% is medication in the form of an eye drop that is used to lower the pressure inside your eye(s), also referred to as intraocular pressu...
ALOCRIL® ophthalmic solution is a prescription eye drop for itchy allergy eyes. ALOCRIL® provides control beyond relief by providing continuous symptom control throughout the allergy season....
Medicine Products: