Navigation Links
Tracking proteins behaving badly provides insights for treatments of brain diseases

A research team led by the University of Melbourne, Australia, has developed a novel technique that tracks diseased proteins behaving badly by forming clusters in brain diseases such as Huntington's and Alzheimer's.

The technique published in Nature Methods today is the first of its kind to rapidly identify and track the location of diseased proteins inside cells and could provide insights into improved treatments for brain diseases and others such as cancer.

Developed by Dr Danny Hatters and his team of the Department of Biochemistry and Molecular Biology at the Bio21 Institute, University of Melbourne, the technique uses a flow cytometer to track the protein clusters in cells at a rate of 1000s per minute. In addition, cells with clustered proteins can be recovered for further study - neither of which had been possible before.

"Being able to identify locations of diseased proteins in cells enables drugs to be developed to target different stages of disease development," he said.

He said the technique has application to many neurological diseases, which are characterised by formations of proteins clustering such as in Alzheimer's, Parkinson's and Huntington's diseases.

"A challenge for researchers has been trying to understand how proteins cluster and cause damage in diseases like Huntington's and Alzheimer's. This is the first approach which could enable us to answer those questions."

"Now we can see how the proteins form clusters inside a cell and can examine which cell functions are being damaged at different steps of the clustering process."

"No drugs at this stage can stop the clustering process in Huntington's disease for example. This sets up platforms to develop drugs that block the formation of clusters," Dr Hatters said.

The technique can also be used to examine how signaling processes occur such as when genes are switched on and off.

"It has application to track events of abnormal gene signaling such as in cancer " Dr Hatters said.

"This technique offers hope in improving treatments for a range of neurological and other conditions," he said.

This work builds on Dr Hatters previous research where he and his team identified the behaviour of diseased Huntington proteins forming into clusters.

The work was done in collaboration with Monash University.


Contact: Rebecca Scott
University of Melbourne

Related medicine news :

1. New high definition fiber tracking reveals damage caused by traumatic brain injury, Pitt team finds
2. Tracking genes remote controls
3. Tracking Lyme Disease in Dogs May Help Protect Humans
4. You are what you tweet: Tracking public health trends with Twitter
5. Tracking groundwater pollution to its source
6. Tracking Swine Flu Virus in Pigs Reveals Mutations
7. Tracking down the origin of leukemia relapse
8. Tracking down particulates
9. Tracking PSA Test Results Over Time Gives Clues to Cancer
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution
Post Your Comments:
(Date:11/30/2015)... Caicos Islands, BWI (PRWEB) , ... December 01, 2015 , ... ... Recently Caribbean Journal, one of the leading digital news sites highlighting Caribbean destinations, ... reason? The weather. While much of North America shivers under chilly grey skies ...
(Date:11/30/2015)... ... 01, 2015 , ... Live Very Well is excited to ... on . The multi-carrier insurance exchange platform offers individual vision and ... to compare, quote and match plans to meet their needs. , Beginning ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... four states in the U.S. require dental technicians to be certified or obtain ... industry, NADL created the “What’s In Your Mouth?” campaign to inform dentists that ...
(Date:11/30/2015)... ... November 30, 2015 , ... The world of hair transplants and restoration ... extraction. These techniques and procedures have been in use for many years and are ... Dr. Parsa Mohebi, M.D. has utilized many of these methods over the years, he ...
(Date:11/30/2015)... ... 30, 2015 , ... During the week of Thanksgiving, the ... for its research, education, support, and advocacy efforts. The campaign is held every ... Mesothelioma Applied Research Foundation, which also goes by Meso Foundation, holds the ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Nov. 30, 2015 MEDTEC Japan 2016, Asia,s ... is to be held in Tokyo from 20 th  - 22 nd April ... --> -->   --> --> ... the United States . With the aging population and the government ... grow steadily. --> the United States . With the ...
(Date:11/30/2015)... 30, 2015 Diplomat Pharmacy, Inc. (NYSE: ... the Detroit Free Press as a Top Workplace , ... to work for in 2015. ... 100 winners annually, based on employee surveys rating company leadership, ... Workplaces are based solely on employee feedback. The survey is ...
(Date:11/30/2015)...  IBA Molecular North America, Inc. (IBAMNA), a U.S. ... that as of January 1, 2016, it will do ... to rebrand the company reflects a refined vision for ... close relationship with Zevacor Molecular.  Both IBAMNA and Zevacor ... Peter Burke , Vice President Sales ...
Breaking Medicine Technology: