Navigation Links
Tracking proteins behaving badly provides insights for treatments of brain diseases
Date:3/19/2012

A research team led by the University of Melbourne, Australia, has developed a novel technique that tracks diseased proteins behaving badly by forming clusters in brain diseases such as Huntington's and Alzheimer's.

The technique published in Nature Methods today is the first of its kind to rapidly identify and track the location of diseased proteins inside cells and could provide insights into improved treatments for brain diseases and others such as cancer.

Developed by Dr Danny Hatters and his team of the Department of Biochemistry and Molecular Biology at the Bio21 Institute, University of Melbourne, the technique uses a flow cytometer to track the protein clusters in cells at a rate of 1000s per minute. In addition, cells with clustered proteins can be recovered for further study - neither of which had been possible before.

"Being able to identify locations of diseased proteins in cells enables drugs to be developed to target different stages of disease development," he said.

He said the technique has application to many neurological diseases, which are characterised by formations of proteins clustering such as in Alzheimer's, Parkinson's and Huntington's diseases.

"A challenge for researchers has been trying to understand how proteins cluster and cause damage in diseases like Huntington's and Alzheimer's. This is the first approach which could enable us to answer those questions."

"Now we can see how the proteins form clusters inside a cell and can examine which cell functions are being damaged at different steps of the clustering process."

"No drugs at this stage can stop the clustering process in Huntington's disease for example. This sets up platforms to develop drugs that block the formation of clusters," Dr Hatters said.

The technique can also be used to examine how signaling processes occur such as when genes are switched on and off.

"It has application to track events of abnormal gene signaling such as in cancer " Dr Hatters said.

"This technique offers hope in improving treatments for a range of neurological and other conditions," he said.

This work builds on Dr Hatters previous research where he and his team identified the behaviour of diseased Huntington proteins forming into clusters.

The work was done in collaboration with Monash University.


'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Related medicine news :

1. New high definition fiber tracking reveals damage caused by traumatic brain injury, Pitt team finds
2. Tracking genes remote controls
3. Tracking Lyme Disease in Dogs May Help Protect Humans
4. You are what you tweet: Tracking public health trends with Twitter
5. Tracking groundwater pollution to its source
6. Tracking Swine Flu Virus in Pigs Reveals Mutations
7. Tracking down the origin of leukemia relapse
8. Tracking down particulates
9. Tracking PSA Test Results Over Time Gives Clues to Cancer
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... ... Aimed at nurses and employees in the health care world, this installment ... nursing and health care industry. It also provides insight to the developing trends and ... As the nursing industry is coming out of one of the biggest recessions in ...
(Date:5/27/2016)... ... 27, 2016 , ... With a team of certified experts, ... Aside from its GMP accreditation, Validation Center is also a registered authority of ... and staff. , Validation Center is ISO17025 accredited and only offers its clients ...
(Date:5/26/2016)... Washington, DC (PRWEB) , ... May 26, 2016 , ... ... the National Hot Dog and Sausage Council (NHDSC) suggests that Americans prefer their dogs ... hot dogs, 63 percent say grilling is their favorite way to cook a hot ...
(Date:5/26/2016)... California (PRWEB) , ... May 26, 2016 , ... ... associated with discovery of thousands of defective respirators, according to court documents and ... the case of William and Becky Tyler v. American Optical Corporation, Case No. ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... in intellectual property (IP) to its specialty academic programs. , Answering to the ... college’s existing certificate programs in health law, and environmental and land use law. ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... 27, 2016 Kitov ... focused on late-stage drug development, today announced the ... of pivotal batches required for registration of KIT-302 ... This follows Kitov,s announcement in December ... met its primary efficacy endpoint. "We ...
(Date:5/27/2016)... YORK , May 27, 2016 ... biotechs, drug manufacturers, health insurance companies all falling under ... small healthcare companies. While not often talked about, these ... The United States is by far ... world. Advanced Medical Isotope Corp. (OTC: ADMD), Nutranomics Inc. ...
(Date:5/26/2016)... India , May 26, 2016 ... drugs market growth is the emergence of new treatments. ... astaxanthin therapies for osteoarthritis treatment. The therapy is expected ... Moreover, Arthritis Research UK is conducting studies to develop ... arcOGEN study, where the genes involved in osteoarthritis are ...
Breaking Medicine Technology: