Navigation Links
Tracking proteins behaving badly provides insights for treatments of brain diseases
Date:3/19/2012

A research team led by the University of Melbourne, Australia, has developed a novel technique that tracks diseased proteins behaving badly by forming clusters in brain diseases such as Huntington's and Alzheimer's.

The technique published in Nature Methods today is the first of its kind to rapidly identify and track the location of diseased proteins inside cells and could provide insights into improved treatments for brain diseases and others such as cancer.

Developed by Dr Danny Hatters and his team of the Department of Biochemistry and Molecular Biology at the Bio21 Institute, University of Melbourne, the technique uses a flow cytometer to track the protein clusters in cells at a rate of 1000s per minute. In addition, cells with clustered proteins can be recovered for further study - neither of which had been possible before.

"Being able to identify locations of diseased proteins in cells enables drugs to be developed to target different stages of disease development," he said.

He said the technique has application to many neurological diseases, which are characterised by formations of proteins clustering such as in Alzheimer's, Parkinson's and Huntington's diseases.

"A challenge for researchers has been trying to understand how proteins cluster and cause damage in diseases like Huntington's and Alzheimer's. This is the first approach which could enable us to answer those questions."

"Now we can see how the proteins form clusters inside a cell and can examine which cell functions are being damaged at different steps of the clustering process."

"No drugs at this stage can stop the clustering process in Huntington's disease for example. This sets up platforms to develop drugs that block the formation of clusters," Dr Hatters said.

The technique can also be used to examine how signaling processes occur such as when genes are switched on and off.

"It has application to
'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New high definition fiber tracking reveals damage caused by traumatic brain injury, Pitt team finds
2. Tracking genes remote controls
3. Tracking Lyme Disease in Dogs May Help Protect Humans
4. You are what you tweet: Tracking public health trends with Twitter
5. Tracking groundwater pollution to its source
6. Tracking Swine Flu Virus in Pigs Reveals Mutations
7. Tracking down the origin of leukemia relapse
8. Tracking down particulates
9. Tracking PSA Test Results Over Time Gives Clues to Cancer
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... December 22, 2014 Physicians in China ... for the treatment of non-Hodgkin’s lymphoma (NHL), according to ... leading global healthcare consulting firm. MabThera is the only ... the most common form of NHL. , According to ... Barriers,” the incidence of NHL in China has been ...
(Date:12/22/2014)... 22, 2014 Explorys, the leader in ... its leadership team: Greg Yarrington as Vice President of ... Patrick Wells as Vice President of Solutions. These new ... new jobs in 2015 to support client demand for ... platform-as-a-service offerings, and growth of its partner network. ...
(Date:12/22/2014)... 2014 In recognition of Veteran’s Day, ... Hero Reward, a local organization that provides services to ... , Located on a couple hundred acres in the ... lodging, world class fishing, hunting, hiking, horseback riding, 4-wheeling, ... several years ago to support U.S. Service men and ...
(Date:12/22/2014)... New York NY (PRWEB) December 22, 2014 ... reports that a federal panel of judges has granted ... lawsuits in the U.S. District Court, Eastern District ... (JPML) issued an order on December 12 to transfer ... actions–pending in 22 districts to the Louisiana court for ...
(Date:12/22/2014)... 2014 Luxury Linen purveyor Peacock Alley ... Dallas to provide logistics and support for one of ... has a long history of giving back to the community ... this year's Toy Drive were Whataburger® and 99.5 The Wolf. ... the holidays. Providing gifts to children who would otherwise not ...
Breaking Medicine News(10 mins):Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 2Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 3Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 3Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 4Health News:Peacock Alley and Community Partners of Dallas Fulfill an Estimated 12,000 Holiday Wishes for Deserving Children 2
... to treat bipolar disorder are more likely to get ... the //Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). ... National Institutes of Health’s (NIH) National Institute of Mental ... 2007 issue of the Archives of General Psychiatry. ...
... it off as just a part of growing older and ... ,“I was increasingly having painful menstrual periods, cramping, ... ,After running some tests, her doctor discovered that Ruma ... women, usually of childbearing age. In addition to painful menstrual ...
... Hindus and Sikhs to be allowed to hold open-air funerals, ... a charity //fighting for the cause being allowed to present ... the Anglo Asian Friendship Society, has been given permission to ... Justice Andrew Collins. ,The development follows a legal ...
... sun appears to impact more on the skin of males than ... exposed a breed of hairless mice to ultraviolet rays from a ... WebMD, The mice underwent eight- to 10-minute tanning sessions three times ... male and female mice skin cancer. ,"We found males ...
... This is one line of thought bra-burning women libbers ... book - Dressed To Kill (Avery Press, revised edition 2001) by ... had come out with claims that wearing a bra throughout ... , The authors claim to have discovered a possible trigger ...
... the chaos created by striking nurses, dentists have thrown in their ... medical card holders stand to lose access to free oral healthcare, ... voting for a withdrawal of support for the Dental Treatment Services ... scheme set up in 1994 to provide free oral ...
Cached Medicine News:Health News:Intensive Psychotherapy Effective in Treating Bipolar Disorder 2Health News:Intensive Psychotherapy Effective in Treating Bipolar Disorder 3Health News:Hope for Ending the Pain, Infertility of Endometriosis? 2Health News:Hope for Ending the Pain, Infertility of Endometriosis? 3Health News:Breast Cancer and Bra Wearing: Possibly Linked 2
(Date:12/22/2014)... Dec. 22, 2014  Mark Farrah Associates (MFA), ... a summary of the 2015 marketplace exchange projections ... According to a recent ASPE ... Evaluation, Department of Health and Human Services) report, ... individual medical plans through the Marketplace as of ...
(Date:12/19/2014)...  In the Friday, December 19 edition of ... Information Technology (HIT) features Konica Minolta, the company announced today. The ... several leading healthcare organizations. In addition to the ... such as New York , Chicago ... , Minneapolis and San Francisco ...
(Date:12/19/2014)... , Dec. 19, 2014 Breckenridge Pharmaceutical, Inc. ... agreement with MSN Laboratories Pvt. Ltd. ( Hyderabad, ... to commercialize several new ANDAs.  Under the terms of ... products exclusively to Breckenridge for the U.S. market, and ... label.  Breckenridge and MSN have agreed to develop an ...
Breaking Medicine Technology:Insights into the Marketplace and Individual Market Growth 2USA Today Supplement Featuring Konica Minolta Focuses on Impact of Healthcare IT 2Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2
... /PRNewswire-FirstCall/ -- VION,PHARMACEUTICALS, INC. announced that it presented ... 43rd Annual Meeting of The American,Society of Clinical ... as a single agent in a Phase II ... lung cancer. , The Phase II trial evaluates ...
... Reports EORTC 40983 (EPOC),Intergroup Study Results, CHICAGO, ... the,randomized phase III EORTC 40983 Intergroup study, ... that peri-operative (pre and post,surgery) FOLFOX4 (Eloxatin(R) ... regimen for colon cancer,5-fluorouracil/leucovorin (5-FU/LV)) given to ...
Cached Medicine Technology:Vion Pharmaceuticals Presents Updated Clinical Data from a Phase II,trial of Cloretazine (VNP40101M) in Patients with Relapsed or,Refractory Small Cell Lung Cancer 2Vion Pharmaceuticals Presents Updated Clinical Data from a Phase II,trial of Cloretazine (VNP40101M) in Patients with Relapsed or,Refractory Small Cell Lung Cancer 3Vion Pharmaceuticals Presents Updated Clinical Data from a Phase II,trial of Cloretazine (VNP40101M) in Patients with Relapsed or,Refractory Small Cell Lung Cancer 4The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 2The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 3The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 4The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 5The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 6The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 7The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 8The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved,Progression Free Survival When Given Before and After Surgery in,Patients With Resectable Liver Metastases From Colorectal Cancer 9
... VenaCure Laser Vein Treatment. It is estimated ... worldwide have varicose veins. In the United States, ... of 60 suffer from painful and unsightly venous ... the capabilities of vascular therapy for the treatment ...
ELVeS is a new minimally-invasive laser treatment for patients with superficial vein reflux of the greater saphenous vein. The ELVeS laser treatment offers your patients an effective out-patient alt...
... technology provides practitioners with the ability to treat ... permanent hair reduction on all skin types and ... the practitioner to instantly switch to a 3, ... a simple twist of the handpiece dial while ...
... people are diagnosed with varicose veins every ... never seek treament and are apprehensive of ... them an effective alternative to conventional therapies., ... hook phlebectomy), is considered a laborious procedure ...
Medicine Products: