Navigation Links
Tracking proteins behaving badly provides insights for treatments of brain diseases
Date:3/19/2012

A research team led by the University of Melbourne, Australia, has developed a novel technique that tracks diseased proteins behaving badly by forming clusters in brain diseases such as Huntington's and Alzheimer's.

The technique published in Nature Methods today is the first of its kind to rapidly identify and track the location of diseased proteins inside cells and could provide insights into improved treatments for brain diseases and others such as cancer.

Developed by Dr Danny Hatters and his team of the Department of Biochemistry and Molecular Biology at the Bio21 Institute, University of Melbourne, the technique uses a flow cytometer to track the protein clusters in cells at a rate of 1000s per minute. In addition, cells with clustered proteins can be recovered for further study - neither of which had been possible before.

"Being able to identify locations of diseased proteins in cells enables drugs to be developed to target different stages of disease development," he said.

He said the technique has application to many neurological diseases, which are characterised by formations of proteins clustering such as in Alzheimer's, Parkinson's and Huntington's diseases.

"A challenge for researchers has been trying to understand how proteins cluster and cause damage in diseases like Huntington's and Alzheimer's. This is the first approach which could enable us to answer those questions."

"Now we can see how the proteins form clusters inside a cell and can examine which cell functions are being damaged at different steps of the clustering process."

"No drugs at this stage can stop the clustering process in Huntington's disease for example. This sets up platforms to develop drugs that block the formation of clusters," Dr Hatters said.

The technique can also be used to examine how signaling processes occur such as when genes are switched on and off.

"It has application to track events of abnormal gene signaling such as in cancer " Dr Hatters said.

"This technique offers hope in improving treatments for a range of neurological and other conditions," he said.

This work builds on Dr Hatters previous research where he and his team identified the behaviour of diseased Huntington proteins forming into clusters.

The work was done in collaboration with Monash University.


'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Related medicine news :

1. New high definition fiber tracking reveals damage caused by traumatic brain injury, Pitt team finds
2. Tracking genes remote controls
3. Tracking Lyme Disease in Dogs May Help Protect Humans
4. You are what you tweet: Tracking public health trends with Twitter
5. Tracking groundwater pollution to its source
6. Tracking Swine Flu Virus in Pigs Reveals Mutations
7. Tracking down the origin of leukemia relapse
8. Tracking down particulates
9. Tracking PSA Test Results Over Time Gives Clues to Cancer
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... of the most popular and least understood books in the Holy Scriptures, Revelation. The ... that have baffled scholars for centuries. Many have tossed it off as mere rubbish, ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of ... Philippines. “The Journey: From the Mountains to the Mission Field” is the creation of ... taught all ages and currently teaches a class of ladies at her church, which ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated ... in breathing. Oral appliances can offer significant relief to about 75 percent of ...
(Date:10/12/2017)... ... ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s premier ... of the shoulder pad. The shoulder pad provides optimal support and full contact ... using cold therapy. By utilizing ice and water that is circulated from an insulated ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the ... to develop to enable prevention of a major side effect of chemotherapy in ... in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., ... analytics, today announced that it has been ranked #1 by ... Black Book™ Rankings 2017 User Survey. ZirMed was recognized ... for large hospitals and medical centers over 200 beds and ... Book,s healthcare technology user survey history. ...
Breaking Medicine Technology: