Navigation Links
Tracking how breast cancer spreads: Einstein receives $10M NIH grant
Date:6/19/2014

June 19, 2014 (BRONX, NY) The American Cancer Society predicts that 40,000 American women will die from breast cancer this year. Most of those deaths will occur due to cells from the primary tumor that spread to other parts of the bodythe process known as metastasis. Now, the National Cancer Institute, part of the National Institutes of Health (NIH), has awarded a $10 million grant to researchers at Albert Einstein College of Medicine of Yeshiva University to fund research into how breast cancer cells move and spread in the body, and how to predict which breast cancer tumors will metastasize.

"The main clinical problem is that there is no widely reliable test to determine the likelihood that metastasis will occur in an individual breast-cancer patient," said John Condeelis, Ph.D., the principal investigator on the grant. "Current tests focus on indirect measuressuch as biomarkers indicating the growth of the primary tumorthat are not directly related to metastasis. We're trying to change that." Dr. Condeelis is professor and co-chair of anatomy and structural biology, co-director of the Gruss Lipper Biophotonics Center and the Judith and Burton P. Resnick Chair in Translational Research at Einstein.

Over the past 10 years, Dr. Condeelis and his colleagues at the Tumor Microenvironment and Metastasis Program at the NCI-designated Albert Einstein Cancer Center, have studied how cancer cells move and spread. The researchers use intravital imaging, a technology that allows them to track individual cells and molecules moving within living animals in real time. Their studies of the molecular mechanisms underlying metastasis have revealed the complex cellular cross-talk that pulls and pushes certain primary tumor cells, helping them penetrate blood vessels, where they are carried by the bloodstream to other parts of the body.

The Einstein scientists have already shown that tumor cells "primed" to metastasize secrete a protein that attracts immune cells called macrophages. Tumor cell/macrophage pairs then migrate toward nearby blood vessels, drawn by endothelial cells that make up the blood-vessel wall. Most significantly, they have found that the close proximity in breast cancer tissue of a trio of cellsa tumor cell, a macrophage and an endothelial cellis a sign that breast cancer metastasis may occur. This trio of cells is called a tumor microenvironment of metastasis, or TMEM.

The Einstein researchers have developed a test that counts the number of TMEMs within a given portion of biopsy tissue: the more TMEMs present, the greater the likelihood that the tumor will metastasize. A recent study in the Journal of the National Cancer Institute found that the TMEM test was more accurate than currently marketed tests in predicting whether breast tumors will spread.

The new NIH grant will help Dr. Condeelis and his colleagues deepen their insights into metastasis. In particular, the researchers will study the various subpopulations of macrophages that are present in primary and metastatic tumors. They hope to determine how these macrophage subpopulations differentially affect three key processes involved in cancer metastasis: intravasation (when cells from the primary tumor penetrate blood vessels), extravasation (when bloodborne tumor cells exit blood vessels after being carried to distant parts of the body) and angiogenesis (the formation of blood vessels to nourish growing tumors). In addition to Dr. Condeelis, the project leaders of the program project grant are Jeffrey Pollard, Ph.D., Richard Stanley, Ph.D., Dianne Cox, Ph.D., Jeffrey Segall, Ph.D., Jon Backer, M.D., and Anne Bresnick, Ph.D.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Tracking Love, Lust in the Brain
2. Tracking the wave of success for Team GBs swimmers
3. AFTS Labs Partners With Physicians To Complement NY's Mandated I-STOP Tracking System For Pain Pill Prescriptions: A Recipe For A Safer Community
4. Cell-Based Tracking Devices Might Help Monitor Treatments
5. Health Officials Tracking Salmonella Outbreak Linked to Pet Turtles
6. Tracking environmental causes of good and bad health
7. New tumor tracking technique may improve outcomes for lung cancer patients
8. Tracking down smallest biomarkers
9. Tracking the origins of HIV
10. Tracking the spread of dengue fever: Domestic networks drive rapid transmission of human infection
11. Cornerstone Municipal President to Speak on Tracking Part Time Employment Status Under PPACA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
(Date:6/24/2016)... Frederick, Maryland (PRWEB) , ... June 24, 2016 ... ... Mid-Atlantic Angels is actively feeding the Frederick area economy by obtaining investment capital ... support over the past 2½ years that have already resulted in more than ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ... company developing innovative inhaled drugs, announced today that it ... Russell Investments reconstituted its comprehensive set of U.S. ... "This is an important milestone for Pulmatrix," said ... increase shareholder awareness of our progress in developing drugs ...
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
Breaking Medicine Technology: