Navigation Links
Tracking genes' remote controls
Date:1/9/2012

As an embryo develops, different genes are turned on in different cells, to form muscles, neurons and other bodily parts. Inside each cell's nucleus, genetic sequences known as enhancers act like remote controls, switching genes on and off. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, can now see and predict exactly when each remote control is itself activated, in a real embryo. Their work is published today in Nature Genetics.

Stefan Bonn, Robert Zinzen and Charles Girardot, all in Eileen Furlong's lab at EMBL, found that specific combinations of chromatin modifications chemical tags that promote or hinder gene expression are placed at and removed from enhancers at precise times during development, switching those remote controls on or off.

"Our new method provides cell-type specific information on the activity status of an enhancer and of a gene, within a developing multicellular embryo," says Furlong.

The scientists looked at known enhancers, and compared those that were active to those that were inactive in a type of cells called mesoderm at a particular time in fruit fly development. They noted what chromatin modifications each of those enhancers had, and trained a computer model to accurately predict if an enhancer is active or inactive, based solely on what chromatin marks it bears.

In future, the scientists plan to use this method to study the interplay between the activity status of an enhancer and the presence of key switches, termed transcription factors, at different stages of embryonic development, and in different tissue types, generating an ever more complete picture of how a single cell grows into a complex organism.


'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1

Related medicine news :

1. ASAP Systems Pioneers the Use of Built-In Video Help on their Passport Inventory, Stock, Warehouse Management System and Asset Tracking Software
2. The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide
3. Massive Food Flavoring Recall Underscores Need for New Tracking Technology to Contain Outbreaks of Foodborne Illness
4. Tickerspy.com Announces New Stock Index Tracking Chinese Healthcare Stocks
5. COO Becomes 75% More Effective in Tracking Delegated Tasks
6. TalentWise Integrates Employment Screening with Leading Applicant Tracking Solution for Healthcare Industry TalentWise becomes HealthcareSource Certified Integration Partner For Position Manager Product
7. Newest Release of FileTrail Sets New Standard in Global Physical Records Management and File Tracking
8. USPack Courier Brings Tracking Precision to Medical and Blood Shipments
9. Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Tracking PSA Test Results Over Time Gives Clues to Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking genes' remote controls
(Date:6/3/2015)... On Sunday, June 7, 2015, tens of ... their local communities to observe the 28th annual National ... and abroad will hold celebrations on this day to ... challenges of cancer survivorship, and to show the world ... rewarding, and inspiring.,  , National Cancer Survivors Day® is ...
(Date:6/3/2015)... are challenging and unpredictable times for traditional organizations across ... are rewriting the rules for business as we knew ... businesses to take on a more agile approach in ... On top of this there is a growing trend ... new innovation and approaches to business. , The manager ...
(Date:6/3/2015)... ON (PRWEB) June 03, 2015 On ... a Marketing Authorization (MA), effective immediately, which now permits ... foods that contain oats as ingredients. The MA is ... being developed. All stakeholders should be aware that, unlike ... in the USA, there are restrictions for gluten-free oat ...
(Date:6/3/2015)... Veatch Consulting Services is excited to ... opened for business in April 2006, they have made ... their clients. Each and every year they have worked ... proud to say that they are off to a ... recently added this year is the Customer Review site ...
(Date:6/2/2015)... BALTIMORE, Md. – Ellarea Maria ... about wellness after being diagnosed with lupus. In spite ... lifestyle changes which enhance health, lupus and other autoimmune ... Wellspring for Wellness ,” she offers a holistic approach ... book provides an overview of some autoimmune diseases—especially ...
Breaking Medicine News(10 mins):Health News:Communities to Recognize Cancer Survivors, Raise Awareness on National Cancer Survivors Day® – Sunday, June 7 2Health News:Communities to Recognize Cancer Survivors, Raise Awareness on National Cancer Survivors Day® – Sunday, June 7 3Health News:Communities to Recognize Cancer Survivors, Raise Awareness on National Cancer Survivors Day® – Sunday, June 7 4Health News:Chief Digital Officer of Travelex joins Bayer, Abellio and Just Eat at The Open Mobile Summit London 2Health News:Health Canada Allows For Conditional Use Of Gluten-Free Oats 2Health News:Health Canada Allows For Conditional Use Of Gluten-Free Oats 3Health News:Veatch Consulting Services Is Breaking New Ground in Customer Satisfaction 2Health News:Veatch Consulting Services Is Breaking New Ground in Customer Satisfaction 3Health News:New book offers holistic approach in living with autoimmune diseases 2Health News:New book offers holistic approach in living with autoimmune diseases 3
... By Amanda Gardner HealthDay Reporter , THURSDAY, March ... that screening for prostate cancer does not substantially reduce the ... hand, a good many men might receive false-positive results and ... researchers report in the March 31 online issue of the ...
... A potential new experimental diagnostic test able to quickly ... latent TB infection has been developed. If the preliminary ... larger population sample, the new diagnostic system could allow ... re-emerging pathology. The work was performed by ...
... system to perform in vivo RNAi screens for ... hepatocyte proliferation during chronic liver damage.1 Functional ... of the candidate gene by different shRNAs can ... and also increase the regenerative capacity of chronically ...
... new TNM 7 lung cancer staging system seems to ... of lung cancer following surgery, according to a study ... of Thoracic Oncology . Being able to better ... important, especially given the controversies surrounding the use of ...
... target for lung cancer has been discovered by researchers at ... the protein AIMP2 is highly expressed in lung cancer cells ... show lower survival. The study is published on March 31 ... Lung cancer is one of the world,s most common cancers ...
... leading cancer organizations shows rates of death in the United States ... 2003 and 2007. The findings come from the latest Annual Report ... report also finds that the overall rate of new cancer diagnoses ... than 1 percent per year for the same period. Edward ...
Cached Medicine News:Health News:Prostate Cancer Screening Doesn't Cut Death Rates: Study 2Health News:Prostate Cancer Screening Doesn't Cut Death Rates: Study 3Health News:A new experimental diagnostic test able to quickly distinguish infection from tuberculosis disease 2Health News:A new experimental diagnostic test able to quickly distinguish infection from tuberculosis disease 3
(Date:6/3/2015)... 2015 The treatment pipeline for ... says  GBI Research . ... Acute Myeloid Leukemia Therapeutics Market to 2020 - forecasts ... moderately from $632.6 million in 2013 to $878.6 million by ... Several drugs to treat AML are expected to ...
(Date:6/3/2015)... SHANGHAI , June 3, 2015 MEDTEC China South ... an extension of MEDTEC China 2015, MEDTEC China South has ... attributes, standing out as a key event for the medical ... After many years of challenges, this year marks the successful return ... 10 years after the event first debuted there in 2005. ...
(Date:6/3/2015)... 2015  Lightlake Therapeutics Inc. ("Lightlake") (OTCQB: LLTP), ... its expertise in opioid antagonists, announced today that ... opioid overdose with intranasal naloxone, has commenced a ... to the United States Food and Drug Administration ... a drug intended to treat opioid overdose.  A ...
Breaking Medicine Technology:Novel Acute Myeloid Leukemia Therapies to Offer Clinical Benefit in Small Patient Cohorts 2Novel Acute Myeloid Leukemia Therapies to Offer Clinical Benefit in Small Patient Cohorts 3MEDTEC Successfully Returns to Southern China 2MEDTEC Successfully Returns to Southern China 3Lightlake Therapeutics Inc. Announces Adapt Pharma Limited Commences Rolling NDA Submission To The FDA For Intranasal Naloxone 2Lightlake Therapeutics Inc. Announces Adapt Pharma Limited Commences Rolling NDA Submission To The FDA For Intranasal Naloxone 3
... MUNDELEIN, Ill. , July 20 ... and information systems technology, today announced the addition of ... Sysmex hematology product offering.  The DM1200 enables Sysmex America ... analysis, which improves both the quality of results and ...
... Mich. , July 20 Two southeast Michigan ... in the region.  Delphinus Medical Technologies and Quantum Signal were approved today for ... of Michigan . , , , ... Arbor region continues to be a magnet for growing, high tech companies," ...
Cached Medicine Technology:Sysmex America Begins Distribution of CellaVision® DM1200 2Sysmex America Begins Distribution of CellaVision® DM1200 3Quantum Signal and Delphinus Medical Technologies Awarded MEGA Funding to Expand in Ann Arbor Area 2Quantum Signal and Delphinus Medical Technologies Awarded MEGA Funding to Expand in Ann Arbor Area 3
... With the GE Innova 2100IQ: See the ... legs. Place interventional devices. Its all enabled ... panel that helps deliver excellent image quality ... Innova family systems installed worldwide, more physicians ...
... provides clinically valuable, device-derived information applicable ... to help specialty physicians discern if ... stable or deteriorating. For example, heart ... Medtronic InSync Sentry™ CRT-D system can ...
... (ALS) is a GH dependent protein which is ... acid peptide with a predicted molecular weight of ... confined to a ~150 KDa GH-dependent ternary protein ... or IGF-II, and this unique acid-labile subunit (ALS) ...
... was first identified in 1980 (1) and has ... of appetite (2). PYY is produced by the ... intake, and is found to decrease appetite. The ... the circulation is PYY3-36, the N-terminal truncated form ...
Medicine Products: