Navigation Links
Tracking genes' remote controls
Date:1/9/2012

As an embryo develops, different genes are turned on in different cells, to form muscles, neurons and other bodily parts. Inside each cell's nucleus, genetic sequences known as enhancers act like remote controls, switching genes on and off. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, can now see and predict exactly when each remote control is itself activated, in a real embryo. Their work is published today in Nature Genetics.

Stefan Bonn, Robert Zinzen and Charles Girardot, all in Eileen Furlong's lab at EMBL, found that specific combinations of chromatin modifications chemical tags that promote or hinder gene expression are placed at and removed from enhancers at precise times during development, switching those remote controls on or off.

"Our new method provides cell-type specific information on the activity status of an enhancer and of a gene, within a developing multicellular embryo," says Furlong.

The scientists looked at known enhancers, and compared those that were active to those that were inactive in a type of cells called mesoderm at a particular time in fruit fly development. They noted what chromatin modifications each of those enhancers had, and trained a computer model to accurately predict if an enhancer is active or inactive, based solely on what chromatin marks it bears.

In future, the scientists plan to use this method to study the interplay between the activity status of an enhancer and the presence of key switches, termed transcription factors, at different stages of embryonic development, and in different tissue types, generating an ever more complete picture of how a single cell grows into a complex organism.


'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1

Related medicine news :

1. ASAP Systems Pioneers the Use of Built-In Video Help on their Passport Inventory, Stock, Warehouse Management System and Asset Tracking Software
2. The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide
3. Massive Food Flavoring Recall Underscores Need for New Tracking Technology to Contain Outbreaks of Foodborne Illness
4. Tickerspy.com Announces New Stock Index Tracking Chinese Healthcare Stocks
5. COO Becomes 75% More Effective in Tracking Delegated Tasks
6. TalentWise Integrates Employment Screening with Leading Applicant Tracking Solution for Healthcare Industry TalentWise becomes HealthcareSource Certified Integration Partner For Position Manager Product
7. Newest Release of FileTrail Sets New Standard in Global Physical Records Management and File Tracking
8. USPack Courier Brings Tracking Precision to Medical and Blood Shipments
9. Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Tracking PSA Test Results Over Time Gives Clues to Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking genes' remote controls
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Pa. , June 23, 2016 Bracket ... will launch its next generation clinical outcomes platform, Bracket eCOA ... Meeting held on June 26 – 30, 2016 in ... the first electronic Clinical Outcome Assessment product of its kind ... Booth #715. Bracket eCOA 6.0 is a flexible ...
(Date:6/23/2016)... announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. Colombia ... ... ... ... Astellas is a pharmaceutical ...
(Date:6/23/2016)... , June 23, 2016 The vast ... an outpatient dialysis facility.  Treatments are usually 3 times ... hours per visit, including travel time, equipment preparation and ... patient, but especially grueling for patients who are elderly ... a skilled nursing and rehabilitation centers for some duration ...
Breaking Medicine Technology: