Navigation Links
Tracking genes' remote controls
Date:1/9/2012

As an embryo develops, different genes are turned on in different cells, to form muscles, neurons and other bodily parts. Inside each cell's nucleus, genetic sequences known as enhancers act like remote controls, switching genes on and off. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, can now see and predict exactly when each remote control is itself activated, in a real embryo. Their work is published today in Nature Genetics.

Stefan Bonn, Robert Zinzen and Charles Girardot, all in Eileen Furlong's lab at EMBL, found that specific combinations of chromatin modifications chemical tags that promote or hinder gene expression are placed at and removed from enhancers at precise times during development, switching those remote controls on or off.

"Our new method provides cell-type specific information on the activity status of an enhancer and of a gene, within a developing multicellular embryo," says Furlong.

The scientists looked at known enhancers, and compared those that were active to those that were inactive in a type of cells called mesoderm at a particular time in fruit fly development. They noted what chromatin modifications each of those enhancers had, and trained a computer model to accurately predict if an enhancer is active or inactive, based solely on what chromatin marks it bears.

In future, the scientists plan to use this method to study the interplay between the activity status of an enhancer and the presence of key switches, termed transcription factors, at different stages of embryonic development, and in different tissue types, generating an ever more complete picture of how a single cell grows into a complex organism.


'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1

Related medicine news :

1. ASAP Systems Pioneers the Use of Built-In Video Help on their Passport Inventory, Stock, Warehouse Management System and Asset Tracking Software
2. The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide
3. Massive Food Flavoring Recall Underscores Need for New Tracking Technology to Contain Outbreaks of Foodborne Illness
4. Tickerspy.com Announces New Stock Index Tracking Chinese Healthcare Stocks
5. COO Becomes 75% More Effective in Tracking Delegated Tasks
6. TalentWise Integrates Employment Screening with Leading Applicant Tracking Solution for Healthcare Industry TalentWise becomes HealthcareSource Certified Integration Partner For Position Manager Product
7. Newest Release of FileTrail Sets New Standard in Global Physical Records Management and File Tracking
8. USPack Courier Brings Tracking Precision to Medical and Blood Shipments
9. Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Tracking PSA Test Results Over Time Gives Clues to Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking genes' remote controls
(Date:1/23/2017)... ... January 23, 2017 , ... Zachary Cattell, President of the ... healthcare industry expert at the 2017 Sector Summit hosted by Ivy Tech Community ... host Gerry Dick, will feature an employer and an association representative from five ...
(Date:1/23/2017)... ... January 23, 2017 , ... Moisture measurement is a necessary ... is paramount to success. Selecting an inappropriate measurement method can cause costly errors, ... the same equipment. Rare or expensive substances are wasted and production may even ...
(Date:1/23/2017)... California (PRWEB) , ... January 23, 2017 , ... "ProRandom is a set of camera ... to create dynamic looks in Final Cut Pro X," said Christina Austin - CEO of ... up to two layers of text with video footage. ProRandom works by using a ...
(Date:1/23/2017)... IL (PRWEB) , ... January ... ... and Education Foundation (OREF), in partnership with the American Society of Anesthesiologists® ... Safety Foundation (APSF), the American Academy of Orthopaedic Surgeons (AAOS) and the ...
(Date:1/23/2017)... , ... January 23, 2017 , ... “The Inn at the Mill”: a story ... fears in her quest to become happy and content. , “The Inn at the ... has also lived in Germany and Vermont and is now living in Berks County on ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... NEW YORK , Jan. 23, 2017 /PRNewswire/ ... a long way from conventional syringes with vials ... free systems. These modern devices have become preferred ... demand for prefilled syringes has been rising strongly ... of healthcare facilities are now adopting this format ...
(Date:1/24/2017)... , January 23, 2017 ... Growth A majority of medicines ... formulating Active Pharmaceutical Ingredients (API), and such processes require ... glycol. Production of pharmaceutical solvents continues to ... excluding Japan (APEJ) region as ...
(Date:1/23/2017)... 23, 2017 Endo International plc (NASDAQ / ... today filed a joint motion in the U.S. District ... seeking the entry of a ten-year Stipulated ... disputes between the FTC and Endo relating to the ... its Opana® ER and Lidoderm® products.  It also resolves ...
Breaking Medicine Technology: