Navigation Links
Tracking genes' remote controls
Date:1/9/2012

As an embryo develops, different genes are turned on in different cells, to form muscles, neurons and other bodily parts. Inside each cell's nucleus, genetic sequences known as enhancers act like remote controls, switching genes on and off. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, can now see and predict exactly when each remote control is itself activated, in a real embryo. Their work is published today in Nature Genetics.

Stefan Bonn, Robert Zinzen and Charles Girardot, all in Eileen Furlong's lab at EMBL, found that specific combinations of chromatin modifications chemical tags that promote or hinder gene expression are placed at and removed from enhancers at precise times during development, switching those remote controls on or off.

"Our new method provides cell-type specific information on the activity status of an enhancer and of a gene, within a developing multicellular embryo," says Furlong.

The scientists looked at known enhancers, and compared those that were active to those that were inactive in a type of cells called mesoderm at a particular time in fruit fly development. They noted what chromatin modifications each of those enhancers had, and trained a computer model to accurately predict if an enhancer is active or inactive, based solely on what chromatin marks it bears.

In future, the scientists plan to use this method to study the interplay between the activity status of an enhancer and the presence of key switches, termed transcription factors, at different stages of embryonic development, and in different tissue types, generating an ever more complete picture of how a single cell grows into a complex organism.


'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert  

Page: 1

Related medicine news :

1. ASAP Systems Pioneers the Use of Built-In Video Help on their Passport Inventory, Stock, Warehouse Management System and Asset Tracking Software
2. The Pediatric Dengue Vaccine Initiative Introduces www.DengueWatch.org - a News hub for Tracking Dengue Fever Epidemics Worldwide
3. Massive Food Flavoring Recall Underscores Need for New Tracking Technology to Contain Outbreaks of Foodborne Illness
4. Tickerspy.com Announces New Stock Index Tracking Chinese Healthcare Stocks
5. COO Becomes 75% More Effective in Tracking Delegated Tasks
6. TalentWise Integrates Employment Screening with Leading Applicant Tracking Solution for Healthcare Industry TalentWise becomes HealthcareSource Certified Integration Partner For Position Manager Product
7. Newest Release of FileTrail Sets New Standard in Global Physical Records Management and File Tracking
8. USPack Courier Brings Tracking Precision to Medical and Blood Shipments
9. Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution
10. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
11. Tracking PSA Test Results Over Time Gives Clues to Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking genes' remote controls
(Date:3/29/2017)... ... , ... Hamlin Dental Group, multi-location dental office in North Hollywood , ... are safe and effective options, and can be used alone or in conjunction with ... of care. , Dr. Hamid Reza of Hamlin Dental Group offers other treatments as ...
(Date:3/29/2017)... ... ... has helped over 1.5 million SharePoint users learn the content management system faster and ... for SharePoint was at the farm level. Enterprises using SharePoint Online in Office 365 ... recently released a modified version of the Help System, VisualSP for Site Collections, which ...
(Date:3/28/2017)... ... March 28, 2017 , ... Greenfield Advisors is expanding ... extensive knowledge of appraisals, property values, ad valorem taxation, and government policy to ... for more than 40 years. , “Ruel is a great addition to the ...
(Date:3/28/2017)... Seattle, WA (PRWEB) , ... March 28, 2017 ... ... reach a 22% share of all holidays (IBT World Travel Trends Report). As ... physically challenging, include a range in temperatures, and prolonged sun exposure. In response, ...
(Date:3/28/2017)... Wallingford, CT (PRWEB) , ... March 28, 2017 ... ... hemostatic devices, announces today that the University of Pittsburgh Medical Center (UPMC) will ... Central and Western Pennsylvania. , The program, developed in association with efforts by ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... TORONTO , March 28, 2017 /PRNewswire/ - ... service medical device development firm, announced today that it ... Toronto -based medical device industrial design and productization ... companies throughout North America with ... device talent spanning the design, engineering, regulatory, and manufacturing ...
(Date:3/28/2017)... and TEL AVIV, Israel , March 28, 2017 ... Israel . This new business entity, Emosis Ltd, ... dedicated to research and development of novel assays complementing the mother ... when relevant, locally support commercialization and sales development of Emosis kits. ... This strategic move ...
(Date:3/28/2017)... Mass. , March 28, 2017 ... company developing innovative therapeutics that address significant unmet ... a patent from the Japan Patent Office (JPO) ... connective tissue growth factor (CTGF) for the treatment ... limited to skin fibrosis and proliferative retinopathy (Japanese ...
Breaking Medicine Technology: