Navigation Links
Tracking down smallest biomarkers
Date:11/27/2012

Microvesicles are smallest cell elements which are present in all body fluids and are different, depending on whether a person is healthy or sick. This could contribute to detecting numerous diseases, such as, e.g., carcinomas, at an early stage, and to treating them more efficiently. The problem is that the diameter of the relevant microvesicles generally lies below 100 nm, which makes them technically detectable, but their exact size and concentration hardly possible to determine. A new device is now to provide the metrological basis for these promising biomarkers. The vacuum-compatible version of the Pilatus hybrid pixel detector for X-rays, which was developed by Dectris in cooperation with the Physikalisch-Technische Bundesanstalt (PTB), now allows also the size of nano-particles which, to date, have been difficult to characterize to be determined using small-angle X-ray scattering at low photon energies. The detector can also be used for other X-ray-based techniques.

What makes this detector unique is the size of its total surface (17 cm 18 cm) as well as the fact that it can be operated in vacuum. Operating the detector in vacuum drastically increases the sensitivity of the measuring facility, since the soft X-rays, which are scattered on the sample, are not absorbed by air molecules on their way towards the detector. This device now allows, for example, experiments for size determination of nanoparticles to be carried out with small-angle X-ray scattering (SAXS) also at the absorption edges of the light elements calcium, sulphur, phosphor or silicon at photon energies below 5 keV with high dynamics and good spatial resolution.

For a few months, the new Pilatus X-ray detector has been used for some of PTB's own research projects. At the synchrotron radiation source BESSY II in Berlin-Adlershof, where PTB has been operating its own laboratory for 15 years, scientists are now using the new detector, for example, to establish the urgently needed metrological basis for the size determination of microvesicles. A project carried out within the scope of the European Metrology Research Programme (EMRP) and with the significant participation of the Amsterdam Medical Center in the Netherlands is to contribute decisively to fully exploiting the potential of microvesicles for the early diagnosis of diseases. if/ptb


'/>"/>

Contact: Michael Krumrey
michael.krumrey@ptb.de
49-030-348-17110
Physikalisch-Technische Bundesanstalt (PTB)
Source:Eurekalert  

Related medicine news :

1. New tumor tracking technique may improve outcomes for lung cancer patients
2. Tracking environmental causes of good and bad health
3. Health Officials Tracking Salmonella Outbreak Linked to Pet Turtles
4. Cell-Based Tracking Devices Might Help Monitor Treatments
5. AFTS Labs Partners With Physicians To Complement NY's Mandated I-STOP Tracking System For Pain Pill Prescriptions: A Recipe For A Safer Community
6. Tracking the wave of success for Team GBs swimmers
7. Tracking Love, Lust in the Brain
8. Smallest, Largest Fetuses at Higher Risk of Stillbirth
9. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
10. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
11. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking down smallest biomarkers
(Date:4/28/2017)... ... ... The Radiology Business Management Association (RBMA) is pleased to announce ... process has been in place since the RBMA was founded in 1968 with all ... Jim Hamilton, MHA, CMM, FRBMA, as president. Dr. Dickerson the chief executive officer for ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... exposed to more adverse experiences than children in the general population. That’s because ... abuse, neglect or other family challenges. While no fault of their own, youth ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... of America (UCAOA) and College of Urgent Care Medicine will host industry leaders ... sessions and speakers will help those in the industry adapt to the issues ...
(Date:4/28/2017)... ... April 28, 2017 , ... People are starting to accept ... a hearing aid doesn’t have the stigma it had when great-grandpa wore his hearing ... Greater Boston, in a NALA North American Speaker Series (NASS) segment. “He ...
(Date:4/28/2017)... ... ... Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, has published a ... does not. Yisrayl says with so many titles and names for the Creator, it’s ... with a little Scripture, backed with a lot of research, the truth is undeniable. ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... PLANO, Texas , April 20, 2017  Vivify ... via mobile devices, has been awarded a very significant ... care via EMRs to continual care via digital health. ... of key intellectual property and further secures Vivify,s position ... Vivify, launched in 2009, was the first company to ...
(Date:4/20/2017)... 2017  CVS Pharmacy, the retail division of ... store design to enhance the retail customer experience ... products and expanded beauty selections paired with informational ... new offerings. Together with its innovative digital programs, ... customer experience at CVS Pharmacy.  ...
(Date:4/20/2017)... 20, 2017 NeuroVive Pharmaceutical AB (Nasdaq ... positive preclinical results demonstrating anti-fibrotic effects with ... steatohepatitis (NASH), in an additional well-validated experimental ... has previously shown similar anti-fibrotic effects in ... scientists present novel data demonstrating anti-fibrotic effects ...
Breaking Medicine Technology: