Navigation Links
Tracking down smallest biomarkers

Microvesicles are smallest cell elements which are present in all body fluids and are different, depending on whether a person is healthy or sick. This could contribute to detecting numerous diseases, such as, e.g., carcinomas, at an early stage, and to treating them more efficiently. The problem is that the diameter of the relevant microvesicles generally lies below 100 nm, which makes them technically detectable, but their exact size and concentration hardly possible to determine. A new device is now to provide the metrological basis for these promising biomarkers. The vacuum-compatible version of the Pilatus hybrid pixel detector for X-rays, which was developed by Dectris in cooperation with the Physikalisch-Technische Bundesanstalt (PTB), now allows also the size of nano-particles which, to date, have been difficult to characterize to be determined using small-angle X-ray scattering at low photon energies. The detector can also be used for other X-ray-based techniques.

What makes this detector unique is the size of its total surface (17 cm 18 cm) as well as the fact that it can be operated in vacuum. Operating the detector in vacuum drastically increases the sensitivity of the measuring facility, since the soft X-rays, which are scattered on the sample, are not absorbed by air molecules on their way towards the detector. This device now allows, for example, experiments for size determination of nanoparticles to be carried out with small-angle X-ray scattering (SAXS) also at the absorption edges of the light elements calcium, sulphur, phosphor or silicon at photon energies below 5 keV with high dynamics and good spatial resolution.

For a few months, the new Pilatus X-ray detector has been used for some of PTB's own research projects. At the synchrotron radiation source BESSY II in Berlin-Adlershof, where PTB has been operating its own laboratory for 15 years, scientists are now using the new detector, for example, to establish the urgently needed metrological basis for the size determination of microvesicles. A project carried out within the scope of the European Metrology Research Programme (EMRP) and with the significant participation of the Amsterdam Medical Center in the Netherlands is to contribute decisively to fully exploiting the potential of microvesicles for the early diagnosis of diseases. if/ptb


Contact: Michael Krumrey
Physikalisch-Technische Bundesanstalt (PTB)

Related medicine news :

1. New tumor tracking technique may improve outcomes for lung cancer patients
2. Tracking environmental causes of good and bad health
3. Health Officials Tracking Salmonella Outbreak Linked to Pet Turtles
4. Cell-Based Tracking Devices Might Help Monitor Treatments
5. AFTS Labs Partners With Physicians To Complement NY's Mandated I-STOP Tracking System For Pain Pill Prescriptions: A Recipe For A Safer Community
6. Tracking the wave of success for Team GBs swimmers
7. Tracking Love, Lust in the Brain
8. Smallest, Largest Fetuses at Higher Risk of Stillbirth
9. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
10. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
11. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
Post Your Comments:
Related Image:
Tracking down smallest biomarkers
(Date:10/13/2017)... AR (PRWEB) , ... October 13, 2017 , ... ... with locations throughout Arkansas that offers insurance and financial preparation services, is providing ... the Rock City Rescue organization. , Rock City Rescue is a locally recognized ...
(Date:10/13/2017)... ... October 13, 2017 , ... While it’s often important ... problem. Fortunately, an inventor from Austin, Texas, has identified a solution. , She developed ... darkness or restricted lighting. As such, it eliminates the need to turn on a ...
(Date:10/13/2017)... ... 2017 , ... The International Association of Eating Disorders Professionals ... the field of eating disorders, announces the opening of early registration for the ... at the Omni Resort at ChampionsGate. , The annual iaedp™ Symposium ...
(Date:10/13/2017)... Ill. (PRWEB) , ... October ... ... Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer ... healthcare professionals on guideline updates for the primary prevention of cardiovascular diseases ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ... Aspen Surgical facility in Las Piedras, Puerto ... scalpels and blades. ... that the facility sustained minor structural damage, temporary loss ... Maria. Repairs have been completed, manufacturing operations have resumed, ...
(Date:10/4/2017)... SEOUL, South Korea , Oct. 4, 2017 /PRNewswire/ ... launched its next-generation CPR training aide "cprCUBE" on Kickstarter. ... of chest compression during cardiac arrests with better efficiency ... patient-mannequins. It also offers real-time feedback on efficacy of ... The crowdfunding campaign has a goal to raise ...
(Date:10/2/2017)...  AllianceRx Walgreens Prime, the combined central specialty pharmacy ... benefit manager Prime Therapeutics LLC (Prime), today officially began ... unveiling of new signage at its headquarters in ... a few other company-owned facilities across the country. This ... of whom will begin to see the AllianceRx Walgreens ...
Breaking Medicine Technology: