Navigation Links
Tracking down smallest biomarkers
Date:11/27/2012

Microvesicles are smallest cell elements which are present in all body fluids and are different, depending on whether a person is healthy or sick. This could contribute to detecting numerous diseases, such as, e.g., carcinomas, at an early stage, and to treating them more efficiently. The problem is that the diameter of the relevant microvesicles generally lies below 100 nm, which makes them technically detectable, but their exact size and concentration hardly possible to determine. A new device is now to provide the metrological basis for these promising biomarkers. The vacuum-compatible version of the Pilatus hybrid pixel detector for X-rays, which was developed by Dectris in cooperation with the Physikalisch-Technische Bundesanstalt (PTB), now allows also the size of nano-particles which, to date, have been difficult to characterize to be determined using small-angle X-ray scattering at low photon energies. The detector can also be used for other X-ray-based techniques.

What makes this detector unique is the size of its total surface (17 cm 18 cm) as well as the fact that it can be operated in vacuum. Operating the detector in vacuum drastically increases the sensitivity of the measuring facility, since the soft X-rays, which are scattered on the sample, are not absorbed by air molecules on their way towards the detector. This device now allows, for example, experiments for size determination of nanoparticles to be carried out with small-angle X-ray scattering (SAXS) also at the absorption edges of the light elements calcium, sulphur, phosphor or silicon at photon energies below 5 keV with high dynamics and good spatial resolution.

For a few months, the new Pilatus X-ray detector has been used for some of PTB's own research projects. At the synchrotron radiation source BESSY II in Berlin-Adlershof, where PTB has been operating its own laboratory for 15 years, scientists are now using the new detector, for example, to establish the urgently needed metrological basis for the size determination of microvesicles. A project carried out within the scope of the European Metrology Research Programme (EMRP) and with the significant participation of the Amsterdam Medical Center in the Netherlands is to contribute decisively to fully exploiting the potential of microvesicles for the early diagnosis of diseases. if/ptb


'/>"/>

Contact: Michael Krumrey
michael.krumrey@ptb.de
49-030-348-17110
Physikalisch-Technische Bundesanstalt (PTB)
Source:Eurekalert  

Related medicine news :

1. New tumor tracking technique may improve outcomes for lung cancer patients
2. Tracking environmental causes of good and bad health
3. Health Officials Tracking Salmonella Outbreak Linked to Pet Turtles
4. Cell-Based Tracking Devices Might Help Monitor Treatments
5. AFTS Labs Partners With Physicians To Complement NY's Mandated I-STOP Tracking System For Pain Pill Prescriptions: A Recipe For A Safer Community
6. Tracking the wave of success for Team GBs swimmers
7. Tracking Love, Lust in the Brain
8. Smallest, Largest Fetuses at Higher Risk of Stillbirth
9. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
10. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
11. US Army: Pre-injury cartilage biomarkers associated with subsequent ACL injuries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracking down smallest biomarkers
(Date:1/17/2017)... ... January 17, 2017 , ... ... the National Association of Music Merchants (NAMM) winter trade show, Booth #2876, at ... Etymotic’s ER•4® has long been the gold standard for high-definition, in-ear earphones. This ...
(Date:1/17/2017)... , ... January 17, 2017 , ... ... online continuing education for EMS and firefighting professionals, has released four new continuing ... These new courses are taught live in an online classroom and meet the ...
(Date:1/17/2017)... ... January 17, 2017 , ... SensorInsight ®, an Internet ... in the U.S.A. to offer Internet of Things (IoT) solutions based on ... sensor deployments such as monitoring solutions used to detect potentially hazardous conditions in ...
(Date:1/17/2017)... , ... January 17, 2017 , ... Livionex, Inc., a ... of a double blind clinical study for its dental gel that shows significant reduction ... brand of toothpaste containing triclosan. The study was conducted at the Beckman Laser Institute ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... ranked among the top US security companies for consecutive years, today announced the ... brings a year-long independent board nomination process to a close and positions Lynx ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan 17, 2017 Research and Markets ... by Type (Innovative, Generic), Manufacturer (Captive, Merchant), Synthesis (Synthetic, Biotech), Product ... Global Forecast to 2021" report to their offering. ... The global active pharmaceutical ... from USD 157.95 Billion in 2016, growing at a CAGR of ...
(Date:1/17/2017)... WARSAW, Ind. , Jan. 17, 2017  Zimmer ... leader in musculoskeletal healthcare , today announced ... capitalizes on the strength of the Zimmer Biomet ... D. Delp will assume the position of ... of the Company. Mr. Delp previously served as Zimmer ...
(Date:1/17/2017)... , Jan. 17, 2017 Tempus, ... cancer care, and University Hospitals Seidman Cancer Center ... by making genomic data, advanced molecular analysis and ... researchers, physicians and healthcare providers. ... provide genomic and transcriptomic sequencing and analysis for ...
Breaking Medicine Technology: