Navigation Links
Tracking Cancer Drug's Effectiveness
Date:6/5/2008

Bioluminescence imaging a lower cost tool than MRI for evaluating new drugs, study says

THURSDAY, June 5 (HealthDay News) -- Researchers say they can cheaply and easily track how effective some cancer drugs are at cutting off a tumor's blood supply by using the same gene that gives fireflies their distinctive glow.

Using a technique called bioluminescence imaging (BLI), the University of Teexas Southwestern Medical Center team added a molecule substrate called luciferin to the bloodstream of mice with human breast cancer tumors. The tumors had been altered to carry the firefly gene, so they would emit light when the luciferin reached them.

Using special light-detecting equipment, the researchers detected a correlation between how much light was emitted and the tumors' growth. The light emission fell drastically after a drug designed to disrupt the blood flow to the cancer cells was given to the mice.

"What we've done is offer proof-of-concept that BLI may be an effective and cheaper method to assess drug development and effectiveness," study senior author Dr. Ralph Mason, director of the UT Southwestern Cancer Imaging Center, said in a prepared statement. "The technique is not intended to be used for imaging tumors or diagnosing cancer in humans, but it potentially allows us to do much more efficient preclinical experiments."

He stressed that the effectiveness of BLI would depend greatly on the tumor location.

The findings are available online and were expected to be published in a future issue of The Journal of the Federation of American Societies for Experimental Biology.

BLI has some advantages over magnetic resonance imaging (MRI), considered the gold standard of medical imaging, such as allowing some additional detection of cell viability and lower cost, the researchers said.

"Ultimately, the MRI is much more sophisticated and can do more, but BLI is very straightforward," Mason said. "It's perfect for evaluating new classes of drugs designed to cause acute vascular changes in tumors, because the tests are inexpensive and easy to do."

More information

The U.S. National Library of Medicine has more about diagnostic imaging techniques.



-- Kevin McKeever



SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, May 29, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Baxa Launches Microsite Featuring the MedBoard(TM) Medication Tracking System
2. Tracking and feedback registry helps reduce disparities in breast cancer care
3. Polar, Virgin HealthMiles Partnership Adds Heart Rate Tracking to Employee Health Incentive Program
4. Ekahau Offers Clear Visibility Into Real-Time Location Tracking With Ekahau Vision
5. Four Rivers Software Systems and ECRI Institute Announce New, Real-Time Interfaces to Improve Inventory Management and Patient Safety Alert and Recall Tracking
6. AT4 wireless and Ekahau Partner to Deploy Combined Asset and Staff Tracking Solution for Hospitals
7. AT&T Delivers Benefits of RFID Inventory Tracking to Health First
8. Tracking your carbon footprint
9. KLAS Ranks TeleTracking Bed Management Suite No. 1
10. Breaking Studies at AARC Congress Show Masimo SET and Masimo Rainbow SET to be Accurate, Effective and Uniquely Beneficial in Detecting and Tracking Disease States
11. Tracking Drug Levels Helps Pregnant Women With Epilepsy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/26/2017)... ... September 26, 2017 , ... Atmosera ... Release Management as a Service (RMaaS) to automate the deployment of ... include any companies, e-tailers, and web development agencies who want to improve time-to-revenue ...
(Date:9/26/2017)... ... September 26, 2017 , ... Two ... only entirely new and different, it is scientifically proven as well: ABAlife™. Euromed ... has received an exclusive license agreement with BioTherapeutics Inc. for patented technology for ...
(Date:9/26/2017)... ... 26, 2017 , ... After a summer-long contest to crown ... Designated Drivers proudly announced the winners of the HEROtini Mocktail Challenge at the ... on the challenge of competing in three categories: Best HEROtini Mocktail, Top HEROtini ...
(Date:9/26/2017)... Falls Church, VA (PRWEB) , ... September 26, 2017 , ... ... FDAnews and Cerulean Associates LLC **, Dec. 5-6, 2017 – Arlington, VA, http://www.fdanews.com/fdadataintegrity ... its investigators: “If initial findings indicate the firm’s electronic records may not be trustworthy ...
(Date:9/26/2017)... Scotch Plains, NJ (PRWEB) , ... September 26, ... ... Surgery Fellowship trained orthopedic surgeon and the Chair of the Leg, Ankle, and ... Dr. Kovatis is currently the only fellowship trained orthopedic surgeon at Hackensack UMC ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... , Sept. 6, 2017  Medical professionals ... and skills while treating their patients. Medical ... experience without involving patients. Simulation provides a ... can carry out procedures, refine techniques and ... Integration of new technology, such as augmented ...
(Date:9/5/2017)... Colo. , Sept. 5, 2017 Sapheneia ... XR-29 DoseCheck solution. Scannerside DoseCheck is a third-party Vendor ... existing CT scanners and allows compliance with current MITA ... Sapheneia-Scannerside proprietary XR 29 DoseCheck solution is specifically designed ... and alerts of potential radiation doses over a predefined ...
(Date:9/5/2017)... Pharmaceuticals Inc. (NASDAQ: ORMP ) (TASE: ORMP) ... the development of oral drug delivery systems, announced today ... U.S. Food and Drug Administration (FDA) regarding ORMD-0801, the ... At the meeting, the FDA gave clear ... would be a Biologics License Application (BLA).  Such a ...
Breaking Medicine Technology: