Navigation Links
Tracing unique cells with mathematics
Date:1/23/2014

However, cells with different properties are then distributed randomly on the samples. Therefore Theis's collaborator Christiane Fuchs developed statistical methods to still identify the single-cell properties in the mixture of signals.

Combining model and experiment

On the basis of known biological data, Theis and Fuchs modeled the distribution for the case of genes that exhibit two well-defined regulatory states. Together with biologists Kevin Janes and Sameer Bajikar at the University of Virginia in Charlottesville (USA), they were able to prove experimentally that with the help of statistical methods samples containing ten cells deliver results of higher accuracy than can be achieved through analysis of the same number of single cell samples.

In many cases, several gene actions are triggered by the same factor. Even in such cases, the statistical method can be applied successfully. Fluorescent markers indicate the gene activities. The result is a mosaic, which again can be checked to spot whether different cells respond differently to the factor.

The method is so sensitive that it even shows one deviation in 40 otherwise identical cells. The fact that this difference actually is an effect and not a random outlier could be proven experimentally.


'/>"/>
Contact: Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Tracing the Paralympic movements freak show roots
2. Unique approach needed to accurately assess health of young adult cancer survivors
3. Unique physiology key to diagnosing and treating diabetes in Asian populations
4. FirstVitals Health and Wellness, Inc. awarded $4 Million CMS Innovation Grant for Unique Telehealth Diabetes Progam Focused on Glycemic Control and Prevention of Diabetic Foot Complications
5. Unique program bringing electronic medical record data to ambulances lauded
6. LA BioMed offers unique educational and research opportunity to local high school seniors
7. Heat-shock factor reveals its unique role in supporting highly malignant cancers
8. Brain Scans of Hoarders Show Unique Abnormalities
9. Moffitt Cancer Center melanoma expert reviews unique adverse events with newly approved drug
10. A CNIO team creates a unique mouse model for the study of aplastic anaemia
11. Kings to develop unique sunscreen with Aethic
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracing unique cells with mathematics
(Date:7/14/2014)... Doctor Mike Hamilton from Inception Chiropractic ... company website. The Inception website is a place for ... It's also a place for potential clients to learn ... When contacted at his office, Doctor Hamilton said, "We're ... website. Our site is obviously a great place for ...
(Date:7/14/2014)... 2014 Love Digits LLC has successfully ... Digits. The App brings ancient astrology to the modern ... their compatibility using a five-star rating system. By entering ... instantaneously test their compatibility for love and marriage across ... app’s five-star rating system generates a weighted average of ...
(Date:7/14/2014)... Spine Team Texas continues to stay ... treatment and recovery. Currently all physical therapists at Spine ... for certification in The McKenzie Method. Two therapists, Craig ... program. , “We require certification of our therapists because ... outcomes for spine pain patients,” said Mark Hood, CEO ...
(Date:7/14/2014)... Townsend Security, a leading authority ... IBM i (AS/400, iSeries) Two Factor Authentication Partner ... threats evolve and make passwords ineffective for system ... their applications and implement two factor authentication (2FA). ... for ISVs on the IBM i platform to ...
(Date:7/14/2014)... Crystal Dental has recently announced that it will ... made via LAD Solutions in in order to increase awareness ... in order to draw in new patients that can now ... Dental offers a variety of services for both routine and ... include cosmetic dentistry procedures such as porcelain veneers and dental ...
Breaking Medicine News(10 mins):Health News:Doctor Mike Hamilton From Inception Chiropractic Websites Announces the Launch of Their New Website 2Health News:Love Digits, Numerical Approach to Modern Love, Now Available on iTunes 2Health News:Love Digits, Numerical Approach to Modern Love, Now Available on iTunes 3Health News:Spine Team Texas’ Physical Therapists Complete The McKenzie Method Training and Certification 2Health News:Spine Team Texas’ Physical Therapists Complete The McKenzie Method Training and Certification 3Health News:IBM i ISVs Can Now Easily Integrate Mobile-Based Two Factor Authentication to Increase Security of Solutions 2Health News:IBM i ISVs Can Now Easily Integrate Mobile-Based Two Factor Authentication to Increase Security of Solutions 3Health News:Crystal Dental Announces the Opening of New Office Location in Sacramento 2
... Centre and Kenya has been asked to spell out, account ... intended 134 million. The fund was provided to Kenya to ... have to provide the accounts of how the money was ... Kenya has been ridden with serious corruption problems that have ...
... The burden of HIV, malaria and Tuberculosis in most ... //The European Union, UNAIDS, WHO and the Indian Government ... the diseases. ,"These diseases mostly affect the ... aim to share our experiences and develop strategies to ...
... drug manufactured by German pharmaceutical company TeGenero by medical research ... designed to treat rheumatoid arthritis, leukaemia and multiple sclerosis was ... who fell seriously ill after taking part in a drug ... brain was on fire. Student Nav Modi, 24, said that ...
... an NGO official India’s population stabilization solely rests on ... which has the highest fertility rates. ,'India's population ... an immediate lead in checking population growth' A.R. Nanda, ... ,'If high growth states like Bihar and Uttar Pradesh, ...
... funds to the tune of ?4m or more will be ... This spending should take care of containing// the unhealthy trend, ... gone up by almost 50%. ,A senior medical ... problems with suicidal tendencies, according to Mr Woodward. To enable ...
... high risk of the potentially-fatal condition of pre-eclampsia, should ... Vitamin C and E. // Recent research has suggested that ... and can trigger pre-eclampsia. ,Pre-eclampsia, is a dangerous condition ... women which is a common cause of deaths and still ...
Cached Medicine News:
(Date:7/11/2014)... N.C. , July 11, 2014 ... approaches are evolving across industry sectors to better ... examining better ways to engage with and understand ... inform themselves and make critical purchasing decisions. ... firm, Best Practices, LLC, one area where organizations ...
(Date:7/11/2014)... Research and Markets has announced the addition ... Industry Report 2014" report to their offering. ... And Chinese Medical X-Ray Film Industry Report 2014 is ... of the Global medical X-ray film industry with a ... a basic overview of the industry including definitions, classifications, ...
(Date:7/11/2014)... 2014 Research and Markets  has announced ... 2014-2018" report to their offering. ... is a hollow needle commonly used with a syringe ... extract fluids from it. A hypodermic needle is used ... that cannot be ingested. Hypodermic needles are broadly classified ...
Breaking Medicine Technology:New Technologies Transforming Consumer Marketing Research Playbook 2Global and Chinese Medical X-ray Film Industry Report 2014 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3
... (Nasdaq: NVAX ) announced today that it has ... H1N1 influenza vaccine in Mexico in collaboration with Avimex ... and pharmaceutical products for use in Mexico and more ... is providing financial support for the trial and is ...
... SHENYANG, China, Oct. 20 /PRNewswire-Asia-FirstCall/ -- 3SBio ... China-based biotechnology,company focused on researching, developing, manufacturing and marketing,biopharmaceutical ... of shareholders held on October 12, 2009. , ... re-elected Dr. Jing Lou and Mr.,Moujia Qi to serve ...
Cached Medicine Technology:Novavax Launches Pivotal Clinical Study of Novel 2009 H1N1 VLP Flu Vaccine in Mexico 2Novavax Launches Pivotal Clinical Study of Novel 2009 H1N1 VLP Flu Vaccine in Mexico 3Novavax Launches Pivotal Clinical Study of Novel 2009 H1N1 VLP Flu Vaccine in Mexico 4Novavax Launches Pivotal Clinical Study of Novel 2009 H1N1 VLP Flu Vaccine in Mexico 5
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: