Navigation Links
Tracing unique cells with mathematics
Date:1/23/2014

This news release is available in German.

Each cell in our body is unique. Even cells of the same tissue type that look identical under the microscope differ slightly from each other. To understand how a heart cell can develop from a stem cell, why one beta-cell produces insulin and the other does not, or why a normal tissue cell suddenly mutates to a cancer cell, scientists have been targeting the activities of ribonucleic acid, RNA.

Proteins are constantly being assembled and disassembled in the cell. RNA molecules read blueprints for proteins from the DNA and initiate their production. In the last few years scientists around the world have developed sequencing methods that are capable of detecting all active RNA molecules within a single cell at a certain time.

At the end of December 2013 the journal Nature Methods declared single-cell sequencing the "Method of the Year." However, analysis of individual cells is extremely complex, and the handling of the cells generates errors and inaccuracies. Smaller differences in gene regulation can be overwhelmed by the statistical "noise."

Easier and more accurate, thanks to statistics

Scientists led by Professor Fabian Theis, Chair of Mathematical modeling of biological systems at the Technische Universitaet Muenchen and director of the Institute of Computational Biology at the Helmholtz Zentrum Muenchen, have now found a way to considerably improve single-cell analysis by applying methods of mathematical statistics.

Instead of just one cell, they took 16-80 samples with ten cells each. "A sample of ten cells is much easier to handle," says Professor Theis. "With ten times the amount of cell material, the influences of ambient conditions can be markedly suppressed."
'/>"/>

Contact: Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Tracing the Paralympic movements freak show roots
2. Unique approach needed to accurately assess health of young adult cancer survivors
3. Unique physiology key to diagnosing and treating diabetes in Asian populations
4. FirstVitals Health and Wellness, Inc. awarded $4 Million CMS Innovation Grant for Unique Telehealth Diabetes Progam Focused on Glycemic Control and Prevention of Diabetic Foot Complications
5. Unique program bringing electronic medical record data to ambulances lauded
6. LA BioMed offers unique educational and research opportunity to local high school seniors
7. Heat-shock factor reveals its unique role in supporting highly malignant cancers
8. Brain Scans of Hoarders Show Unique Abnormalities
9. Moffitt Cancer Center melanoma expert reviews unique adverse events with newly approved drug
10. A CNIO team creates a unique mouse model for the study of aplastic anaemia
11. Kings to develop unique sunscreen with Aethic
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tracing unique cells with mathematics
(Date:8/20/2014)... Missouri federal judge has remanded a lawsuit filed by a ... NaturaLyte to the City of St. Louis Circuit Court, reports ... rejected an assertion by the defendants that the plaintiffs’ claims ... v. Fresenius Medical Care North America Inc., et al., No. ... of the dialysis products GranuFlo and NaturaLyte. In 2012, the ...
(Date:8/20/2014)... News) -- Leaving the car at home and getting to ... your health, a new study indicates. Researchers looked at ... 76 percent of men and 72 percent of women drove ... women used public transit, and 14 percent of men and ... drove to work weighed more and had higher levels of ...
(Date:8/20/2014)... The Workgroup for Electronic Data Interchange ... use of health IT to create efficiencies in ... its annual fall conference, WEDI-Con 2014: The Next ... take place at the HYATT Regency in Reston, ... cross-section of payers, providers, government regulators, industry vendors ...
(Date:8/20/2014)... WI (PRWEB) August 20, 2014 Parents ... While the transition from summer months means buying textbooks ... element that is often a forgotten part of the ... , According to the American Psychological Association, 27% of ... year. Nearly half (45%) say they are stressed by ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 Verndale is ... Inc. 500|5000 list; an exclusive list ranking the fastest-growing ... are ranked according to their yearly percentage revenue growth ... 8th time on the Inc. 5000 list where it ... Company, Verndale offers its clients a wide range of ...
Breaking Medicine News(10 mins):Health News:GranuFlo/NaturaLyte Case Remanded to State Court By Missouri Federal Judge, Baron and Budd Reports 2Health News:Want to Stay Slim? Leave the Car at Home 2Health News:WEDI Releases Full Conference Agenda for Its Annual Fall Conference – WEDI-Con 2014 2Health News:WEDI Releases Full Conference Agenda for Its Annual Fall Conference – WEDI-Con 2014 3Health News:Five Easy Steps to Help Your Child Manage Back-to-school Stress 2Health News:Five Easy Steps to Help Your Child Manage Back-to-school Stress 3Health News:For the 8th Time, Verndale Has Been Honored on the Inc. 5000 List 2
... Simple exercise routines can improve lung function and overall fitness ... a small new study suggest. Cystic fibrosis, or CF, ... mucus in the lungs, resulting in frequent lung infections, breathing ... regimens are difficult to adhere to long-term, so a team ...
... at The Scripps Research Institute have found a temperature-sensing protein within ... activate an immune response. This process can occur as temperature rises, ... immune cells are "called" from the body,s warm interior to a ... online ahead of print by Nature Chemical Biology , is ...
... FRIDAY, May 6 (HealthDay News) -- Nail salon workers may ... a new study warns. Researchers recruited 80 Vietnamese women ... their work-related exposure to toluene, ethyl acetate and isopropyl acetate. ... Journal of Public Health , showed that the workers were ...
... bacteria associated with exposure to livestock was recently discovered ... contact with livestock, according to University of Iowa researchers. ... study of Staphylococcus aureus in child day care facilities ... in the UI College of Public Health, for her ...
... Reinberg HealthDay Reporter , THURSDAY, May ... antibiotics can often cure appendicitis, surgery remains the ... appendicitis may be treated with antibiotics alone, but ... surgery, and it is difficult to discern between ...
... May 6 (HealthDay News) -- Americans walked and biked a ... new research finds. But the increases were minor, especially ... in the American Journal of Public Health . ... 2009 U.S. National Household Travel Surveys and found that the ...
Cached Medicine News:Health News:Everyday Exercise Can Help Kids With Cystic Fibrosis: Study 2Health News:Scripps Research scientists show how shifts in temperature prime immune response 2Health News:Scripps Research scientists show how shifts in temperature prime immune response 3Health News:Study finds livestock-related 'Staph' strain in child care worker 2Health News:Surgery May Beat Antibiotics for Appendicitis, Study Finds 2Health News:Surgery May Beat Antibiotics for Appendicitis, Study Finds 3Health News:Americans Walking, Biking a Bit More, Research Shows 2
(Date:8/20/2014)...   Ventana Medical Systems, Inc.  (Ventana), a ... its VENTANA System for Primary Diagnosis 1 ... for routine pathology, including primary diagnosis with human ... software coupled with either the VENTANA iScan Coreo ... automated digital slide creation, case management and computer ...
(Date:8/20/2014)... LAKE CITY , Aug. 20, 2014 ... revolutionary mobile diagnostic platform during a special event at ... Utah , on September 5, 2014. The event, ... LiveStreamed on the ApolloDx website, www.apollodx.com .    ... transform diagnostic testing," said Jared Bauer , Co-Founder ...
(Date:8/20/2014)... , Aug. 20, 2014 Trovagene, Inc. ... announced today that results from two clinical studies will ... for the Company,s urine-based diagnostic test for the detection ... IPV conference is scheduled to take place in ... to 25 th . Additionally, a new U.S. patent ...
Breaking Medicine Technology:Full digitization of the anatomic pathology lab is here with the VENTANA System for Primary Diagnosis 2Full digitization of the anatomic pathology lab is here with the VENTANA System for Primary Diagnosis 3Trovagene Provides Update on Its Urine-Based HPV Test 2Trovagene Provides Update on Its Urine-Based HPV Test 3
... HeartWare International, Inc. (NASDAQ: HTWR ... miniaturized circulatory support technologies that are revolutionizing the treatment ... Godshall is scheduled to present at the Lazard Capital ... p.m. ET on Thursday, September 22, 2011.  The one-day ...
... and SEATTLE, Sept. 19, 2011 Varian ... Calypso Medical Technologies, Inc., today announced they have signed ... a privately-owned, Seattle-based developer and supplier of specialized products ... during radiosurgery and radiotherapy.  The acquisition, which is anticipated ...
Cached Medicine Technology:HeartWare to Present at The Lazard Capital Markets 3rd Annual Circulatory Assist Device Day 2Varian Medical Systems Signs Agreement to Acquire Calypso Medical Technologies; Acquisition Adds Products for Tracking Tumor Motion During Radiosurgery and Radiotherapy 2Varian Medical Systems Signs Agreement to Acquire Calypso Medical Technologies; Acquisition Adds Products for Tracking Tumor Motion During Radiosurgery and Radiotherapy 3Varian Medical Systems Signs Agreement to Acquire Calypso Medical Technologies; Acquisition Adds Products for Tracking Tumor Motion During Radiosurgery and Radiotherapy 4Varian Medical Systems Signs Agreement to Acquire Calypso Medical Technologies; Acquisition Adds Products for Tracking Tumor Motion During Radiosurgery and Radiotherapy 5
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: