Navigation Links
Toxins in cigarette smoke prevent stem cells from becoming cartilage
Date:3/3/2008

A toxic pollutant spread by oil spills, forest fires and car exhaust is also present in cigarette smoke, and may represent a second way in which smoking delays bone healing, according to research presented today at the annual meeting of the Orthopaedic Research Society in San Francisco.

In 2005, researchers from the University of Rochester Medical Center identified one ingredient in smoke, nicotine, that delays bone growth by influencing gene expression in the two-step bone healing process: stem cells become cartilage; cartilage matures into bone. In the current study, some of the same researchers found that a second smoke ingredient, the polyaromatic hydrocarbon benzo(a)pyrene (BaP), also slows bone healing, but in a different way.

Smoking has been shown to delay skeletal healing by as much as 60 percent following fractures. Slower healing means a greater chance of re-injury and can lead to chronic pain and disability. The obvious solution is for smokers to quit when they get hurt, but studies show that just 15 percent can.

Our results provide the first evidence that BaP prevents stem cells from becoming cartilage cells as part of healing, said Regis J. O'Keefe, M.D., Ph.D., chair of the Department of Orthopaedics and Rehabilitation at the Medical Center and a study investigator. These findings extend our understanding of the impact of cigarette smoke on a process that is critical to fracture repair. Perhaps down the road we will be able to speed bone healing among smokers in more than one way.

Study Details

Gene expression is the process by which instructions encoded in genes are followed for the building of proteins, the workhorses that make up the bodys organs and carry its signals. In the current study, polymerase chain reaction (PCR), a technique that measures gene expression levels, revealed the genetic changes caused by exposure to BaP in mouse stem cells.

Among the many factors that influ
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
University of Rochester Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. New study suggests link between environmental toxins and early onset puberty in girls
2. Scientists Find Cancer Culprits in Cigarette Smoke
3. Health Groups Launch Ad Campaign Supporting 70-Cent Increase in Kentucky Cigarette Tax
4. 84 Percent of Utah Voters Favor Cigarette Tax Increase
5. Quitting Marijuana Just as Hard as Quitting Cigarettes
6. Women and cigarettes, the causes for consumption
7. Marijuana withdrawal as bad as withdrawal from cigarettes
8. Cigarettes leave deadly path by purging protective genes
9. Hypnotist ready to kick cigarette butt
10. Smoke-Free Workplace Laws, Cigarette Taxes on the Rise
11. Hookah Smoking as Tough on Lungs as Cigarettes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... Phoseon Technology will present their advanced ... IMI European Ink Jet Conference (June 5-6, Barcelona, ... to invest in product development to enable breakthrough capability ... curing in printing applications. Phoseon currently has a ... both air cooled and water cooled solutions to match ...
(Date:5/21/2013)... May 21, 2013 MedMar Healing Center ... to benefit Second Harvest Food Bank. Twenty-eight businesses, including MedMar ... in the food drive. The goal is to raise food ... economic problems facing their families in recent years. , ... and help those in need,” explains Douglas Chloupek of MedMar ...
(Date:5/21/2013)... two proteins, thrombospondin-1 and prosaposin, play in discouraging ... a five-amino acid fragment of prosaposin that significantly ... breast and lung cancer. The findings suggest that ... a variety of cancers. , The study ... Children,s Hospital, Vivek Mittal, PhD, at Weill Cornell ...
(Date:5/21/2013)... and technological research So Paulo Research Foundation, FAPESP, based ... estimated in US$ 680 million to support 17 Research, ... up to eleven years, subject to continuation reviews on ... the 17 RIDCs will come from FAPESP and the ... infrastructure). Host institutions will participate in a portion of ...
(Date:5/21/2013)... 2013 The Las Vegas personal injury law ... that Crawford Gates, a senior at Coronado High School, is ... essay contest . As the winner of the essay contest, ... started on Dec. 1, 2012 and ran through April 30th, ... a three-page minimum essay on “The Role of the civil ...
Breaking Medicine News(10 mins):Health News:San Jose Cannabis Club Helps Feed Hungry Children with Second Harvest Food Bank 2Health News:Changing cancer's environment to halt its spread 2Health News:Changing cancer's environment to halt its spread 3Health News:Research at the cutting edge of knowledge 2Health News:Benson, Bertoldo, Baker & Carter is Pleased to Announce the Winner of its First Annual College Scholarship Essay Contest 2
... 26 Researchers at Wayne State University ... that may one day lead to new treatments.Prostate cancer, ... affects one in six men. In 2008, nearly ... nearly 186,000 were newly diagnosed, and approximately 28,000 died ...
... interactive pediatric healthcare education and resources for hospitals, physicians, and ... ... Wilmington, DE (PRWEB) March 26, 2009 -- Emmi Solutions ... and information programs, and KidsHealth ®, the largest provider ...
... Venture Capital Community to Drive Innovation through Investment Opportunities ... 26 The 510(k) program is under siege from ... complained in a letter to Congress that CDRH management ... 510(k)s. They followed that complaint to Congress with ...
... 26, 2009 Nearly 90 percent of the 700,000 strokes ... a blockage of blood vessels supplying the brain, known ... Catheterization and Cardiovascular Interventions , the official journal of ... solid evidence of the effectiveness of catheter-based therapy (CBT) ...
... a Mayo Clinic study show that a simple, noninvasive finger ... such as a heart attack or stroke, for people who ... study will be presented Tuesday, March 31, 2009 at 11:30 ... Annual Scientific Session in Orlando (0917-7).The noninvasive finger test device, ...
... Sure There,s a Rollover Bar Above Your Head , ... Bloomington, MN ... buyers of previously owned commercial zero-radius-turn (ZRT) mowers to check that each ... to a roll bar on a race car, an overhead ROPS and ...
Cached Medicine News:Health News:Wayne State University Scientists ID New Biomarker for Prostate Cancer 2Health News:Emmi + KidsHealth = Prescription for Informed and Involved Patients 2Health News:Emmi + KidsHealth = Prescription for Informed and Involved Patients 3Health News:FDA Fireside Chat @ The 8th Annual MedTech Investing Conference May 6-7, 2009 2Health News:FDA Fireside Chat @ The 8th Annual MedTech Investing Conference May 6-7, 2009 3Health News:FDA Fireside Chat @ The 8th Annual MedTech Investing Conference May 6-7, 2009 4Health News:Individualized stroke treatment available for patients, though underutilized 2Health News:Mayo Study Shows Simple Finger Device May Help Predict Future Heart Events, Such as Heart Attack 2Health News:Mayo Study Shows Simple Finger Device May Help Predict Future Heart Events, Such as Heart Attack 3Health News:Safety Alert for Buyers of Used Commercial Zero Turn Mowers 2Health News:Safety Alert for Buyers of Used Commercial Zero Turn Mowers 3Health News:Safety Alert for Buyers of Used Commercial Zero Turn Mowers 4Health News:Safety Alert for Buyers of Used Commercial Zero Turn Mowers 5
(Date:5/21/2013)... and PHILADELPHIA , May 21, ... introduced its new corporate image and impressive new product developments ... Philadelphia . "After ten years of unerring focus on ... we felt the need to mark the occasion," said founding ... time we have some interesting developments of benefit to our ...
(Date:5/21/2013)... , May 21, 2013  Armada Health ... of the new Armada corporate website ( www.armadahealthcare.com ... communicate Armada,s unique and first-to-market services and its ... focused on the specialty pharmacy industry. ... of the Armada business model in delivering an ...
(Date:5/21/2013)... , May 21, 2013  The North Shore-LIJ ... used to measure hand-washing compliance at North Shore University ... introducing cameras in operating rooms at Forest ... http://photos.prnewswire.com/prnh/20130521/NY17810 ) The new pilot program strengthens ... their operating rooms (ORs), the first time in the ...
Breaking Medicine Technology:Pi2 Solutions' 10th Anniversary Heralds New Corporate Image as Platinum Sponsor of SLA PHT Meeting in Philadelphia 2Pi2 Solutions' 10th Anniversary Heralds New Corporate Image as Platinum Sponsor of SLA PHT Meeting in Philadelphia 3Armada Announces New Corporate Website to Showcase Expanded Services to Specialty Pharmacy Marketplace 2North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs 2North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs 3North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs 4
...   New product launches are continually occurring across various ... to balance the dueling goals of containing costs and producing ... determining how much to invest, and how to best spend ... primary care launch is spent before during the launch ...
... this week,s 46th Annual Midyear Clinical Meeting and Exhibition ... Health launched BarCode360™ , a solution that supports ... timely and cost efficient to order medications and ensure ... bedside. ASHP has set a goal for ...
Cached Medicine Technology:Launch Spend Insights: Companies Now Invest More in Launch Year Than in Previous 3 Ramp-Up Years Combined 2Cardinal Health Launches Innovative Barcode Administration Solution to Help Hospitals Bridge Gaps in Medication Safety 2Cardinal Health Launches Innovative Barcode Administration Solution to Help Hospitals Bridge Gaps in Medication Safety 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: