Navigation Links
Toxin from brain cells triggers neuron loss in human ALS model
Date:2/6/2014

eurons."

In the study, Dr. Przedborski and study co-authors Diane Re, PhD, and Virginia Le Verche, PhD, associate research scientists, removed astrocytes from the brain and spinal cords of six ALS patients shortly after death and placed the cells in petri dishes next to healthy motor neurons. Because motor neurons cannot be removed from human subjects, they had been generated from human embryonic stem cells in the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research, also at CUMC.

Within two weeks, many of the motor neurons had shrunk and their cell membranes had disintegrated; about half of the motor neurons in the dish had died. Astrocytes removed from people who died from causes other than ALS had no effect on the motor neurons. Nor did other types of cells taken from ALS patients.

The researchers confirmed that the cause of the motor neurons' death was a toxin released into the environment by immersing healthy motor neurons in the astrocytes' culture media. The presence of the media, even without astrocytes, killed the motor neurons.

How the Toxin Triggers Motor Neuron Death

The researchers have not yet identified the toxin released by the astrocytes. But they did discover the nature of the neuronal death process triggered by the toxin.The toxin triggers a biochemical cascade in the motor neurons that essentially causes them to undergo a controlled cellular explosion.

Drs. Przedborski, Re, and Le Verche found that they could prevent astrocyte-triggeredmotor neuron death by inhibiting one of the key components of this molecular cascade.

These findings may lead to a way to prevent motor neuron death in patients and potentially prolong life. But the therapeutic potential of such inhibition is far from clear. "For example, we don't know if this would leave patients with living but dysfunctional neurons," Dr. Przedborski said. The researchers are now testing the idea of inhibition in
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. NIH-created toxin can kill HIV-infected cells that persist despite treatment
2. How to Sleep Away Harmful Brain Toxins Discussed in Health Nutrition News Video
3. Bel Marra Health Reports on Recent Research Revealing a Dangerous Toxin Linked to Increased Risk of Stroke
4. Research Report on Feed Mycotoxin Absorbent Market in China
5. Environmental toxins linked to heart defects
6. Diet Doc Hormone Diets & Weight Loss Plans Announces Detox Formula, Designed to Cleanse the Liver of Dangerous Toxins & Avoid Weight Loss Plateaus
7. Quality Treatment for Biotoxin Related Illness is Getting Easier to Find
8. Neurotoxin effectively relieves bone cancer pain in dogs, Penn researchers find
9. New Studies Linking Environmental Toxins to Infertility Validate Benefits of Fairhaven Health's FertileDetox
10. European Food Safety Testing Market (Pathogen, GMO, Toxin, Pesticide) Worth $4,068.8 Million by 2018 - New Report by MarketsandMarkets
11. Diet Doc Weight Loss Plans Announces New Detox Formula, Designed to Promote Safe and Rapid Weight Loss By Cleansing the Body of Harmful Toxins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Toxin from brain cells triggers neuron loss in human ALS model
(Date:10/20/2014)... Angeles, CA (PRWEB) October 20, 2014 ... fitness expertise, nutritional coaching, corporate wellness programming, authorship, international ... CPT, is excited to announce the release of the ... , After many years of coaching thousands of individuals ... nutrition tracking app that does not require calorie counting ...
(Date:10/20/2014)... 2014 Rockynol Retirement Community ... Oct. 14. The $11 million project will include the ... cooked-to-order kitchen with full-service restaurant style dining. , “We ... first class Assisted Living apartments,” said Kara Hanzie, Rockynol ... highest quality of care and this investment is proof ...
(Date:10/20/2014)... Unveiled at the Sept. 18 board meeting, The ... member hospital ROI on membership dues at 12.5. In other ... $12.50 in value to member hospitals. The calculation used to ... Dues. , “This is the first time we’ve actually ... the methodology is really sound,” said Bill Ryan , ...
(Date:10/19/2014)... Hastings and Hastings, a Phoenix personal injury law firm ... Phoenix area and across Arizona reports record demand in ... accidents. Statistics have indicated a steady increase in automobile ... Hastings and Hastings has seen a steady increase in ... been injured through no fault of their own that ...
(Date:10/19/2014)... October 20, 2014 Having been working in ... good knowledge of customer needs. According to James, one of ... with dazzling sequins, or with high-low skirts that add beauty ... huge demand. Recently, LunaDress has unveiled its new selection of ... fact, the company’s brand new items are available in over ...
Breaking Medicine News(10 mins):Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2
... , , WEST PALM BEACH, ... leading providers of he a ring aids ... a hearing care program designed exclusively for AARP members. The program is scheduled ... October and will eventually be extended to AARP members in all 50 states ...
... , Dr. Mubin Syed evaluates findings; ... Ohio, Aug. 11 A new study by Mayo Clinic researchers ... of vertebroplasty to treat osteoporotic spinal fractures. , , ... is injected into vertebrae to relieve pain and improve mobility in ...
... , , Survey seeks feedback from ... , , CHICAGO, Aug. 11 Participate in the American ... and become eligible to win a $150 Amazon.com gift certificate ... , ADA.org provides news and information on hundreds of dental ...
... , , FRAMINGHAM, Mass. and SYDNEY, Aug. ... today announced that it is scheduled to make an investor presentation at ... on Thursday, August 13, 2009. The conference will be held at the ... live webcast of the Company,s presentation at the conference will be available ...
... , , LAKEWOOD, Colo., Aug. 11 ... that its Board of Directors has declared a regular quarterly cash ... September 15, 2009 to shareholders of record at the close of ... Laboratories develops, acquires, manufactures and markets electronic instruments and disposables for ...
... , CLEVELAND, Aug. 11 Herbruck ... convene six medical insurance companies on Thursday, August 20 ... impact of pending federal healthcare legislation on employers. ... important because Americans across the country are discussing and ...
Cached Medicine News:Health News:HearUSA Makes Hearing Aids and Care Available to AARP Members 2Health News:HearUSA Makes Hearing Aids and Care Available to AARP Members 3Health News:HearUSA Makes Hearing Aids and Care Available to AARP Members 4Health News:Noted Vertebroplasty Expert Cites Concerns About Recently Published Study 2Health News:American Dental Association Web Survey Offers Chance at $150 Gift Certificate 2
(Date:10/17/2014)... , Oct. 17, 2014 With the ... Affairs function has come across several challenges in ... and managing globalization.  The ... is dedicated to providing benchmarking and best practices ... Consortium is a service composed of three stages: ...
(Date:10/17/2014)... 2014  Hanger, Inc. (NYSE: HGR ) ... of operations for the quarter ended September 30, 2014, ... A conference call to discuss these results is scheduled ... 7, 2014. Those wishing to participate should call 1-877-662-6095. ... 2014 by dialing 1-855-859-2056 and referencing Conference ID # ...
(Date:10/17/2014)... 2014 UBM Medica US announces that ... and information resource for neurologists and other healthcare providers, features ... disease , with discussions of the latest developments in approaches ... have Parkinson disease , more than the total of those ... disease. Diagnosis can be difficult because there are no ...
Breaking Medicine Technology:Early Key Findings from the Medical Affairs Consortium Research 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 3
... Business Council is pleased to announce that General Electric (GE), ... joint ventures in Russia. These joint ventures bolster GE,s position ... power generation and healthcare sectors. Under the ... billion in sales, GE will sell at least 77 gas ...
... NEW YORK, Sept. 16, 2011 Choosing ... be a confusing process.  Referrals from peers and subsequent ... experience and results.  Patients need to be educated on ... go in search of a plastic surgeon for treatment. ...
Cached Medicine Technology:USRBC President Ed Verona Lauds GE Announcement on Energy and Healthcare Joint Ventures in Russia 2Trust Your Derm: The JUVA Skin & Laser Center Advises Patients To Seek Board Certified Dermatologists and AAAHC Accredited Facilities For Safe Cosmetic Procedures 2
Chin Implants are used for cosmetic augmentation, repairing trauma related injuries and genetic deficiencies. They are inserted through an incision in the mouth below the incisor teeth or through an ...
... The IEC CL40 and FL40 ... power, safety and versatility to increase ... with a broad array of rotors ... processing and microplate applications, the IEC ...
... The IEC CL30 Series from ... exceptional value for your low-speed ... AUTO-LOCK rotor exchange system, user-friendly ... the IEC CL30 Series delivers ...
Chembio Diagnostic Systems, Inc.s SURE CHECK HIV 1 / 2, HIV 1/ 2 STAT-PAK and HIV 1/ 2 STAT-PAK Dipstick tests are easy-to-perform, single-use diagnostic tests for the rapid, visual detection of anti...
Medicine Products: