Navigation Links
Towards more effective treatment for multiple myeloma
Date:1/9/2012

ells from patients. When used in animal studies with the proteasome inhibitor bortezomib, MAL3-101 significantly boosted its anti-myeloma effects. Dr. Batuman's team found that by targeting Hsp70 activity, the dosage of synergic agents such as bortezomib could be reduced without compromising their effectiveness. The ability to reduce dosage makes it possible to continue the use of drugs that are toxic at higher concentrations. The addition of new synergistic agents also enriches the treatment arsenal by reducing drug resistance.

"The results of our study are very encouraging," says Dr. Batuman. "While this is not a cure and it will be some time before the compound is developed as a drug, we believe that MAL3-101, when used synergistically with existing therapies, could reduce overall drug concentrations and avoid treatment resistance."

Dr. Batuman adds, "It is possible to speculate that MAL3-101 may also modulate development of the multiple myeloma cancer stem cell. The relapse of multiple myeloma in patients in whom complete remission had been achieved is currently thought to indicate the presence of treatment-resistant multiple myeloma cancer stem cells. At Downstate, a group effort is now geared towards identifying and targeting these cancer stem cells in multiple myeloma. The anti-myeloma effects of MAL3-101 could include inhibition of cancer stem cell development, since the Hsp-70 function is required in early plasma cell development. Our prediction is that antagonism of the Hsp-70 chaperone or chaperones by affecting non-redundant pathways could be effective in multiple myeloma treatment."


'/>"/>
Contact: Ron Najman
ron.najman@downstate.edu
718-270-2696
SUNY Downstate Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Chocolate Industry Leaders Sign Agreement, Align on Path Towards Increasing Consumer Availability & Consistency of Beneficial Cocoa Flavanols
2. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
3. Electronic Health Information Leader Says Physician Practice Redesign is Vital Next Step Towards Safer, More Effective Care Delivery
4. Miles for Hope’s Moving Towards A Cure(SM) Brain Tumor Walk in Boston Raising Funds for Brain Tumor Vaccine and Massachusetts General Hospital
5. PaperFree Florida to help move physicians towards electronic health records
6. Study shows behaviors and attitudes towards oral sex are changing
7. Warning about benevolent sexism and mens apparently positive attitudes towards women
8. Top scientists unite to develop global scientific strategy Towards An HIV Cure
9. Steps towards the use of adult stem cells for gene therapy
10. Steps being taken towards achieving an early diagnosis of cancer of the large intestine
11. Transending Borders Towards Global Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... mutation that causes a rare premature aging disease could ... rapid, unstoppable cell division that makes cancer so deadly. ... the U-M Health System recently discovered a protein mutation ... precious hematopoietic stem cells can,t regenerate and make new ... to cancer and bone marrow failure. , But ...
(Date:9/30/2014)... FDA-approved injectable dermal fillers (i.e. hyaluronic ... in several procedures that are performed to restore ... primarily used for wrinkle treatment of the skin, ... are being used as popular treatments in nonsurgical ... the hands. (1) (2) Dr. Cynthia Elliott of ...
(Date:9/30/2014)... Mirada, CA (PRWEB) September 30, 2014 ... Cortes is now performing advanced foot and ankle reconstruction ... a board-certified orthopedic surgeon, Dr. Cortés specializes in the ... and ankle injuries . She is also trained to ... with their orthopedic needs. Dr. Cortés is also fluent ...
(Date:9/30/2014)... September 30, 2014 To mark National ... Board of Living with a Disability magazine ... on hematological disorders as disabling conditions. , ... than a diagnosis to establish a disability related to ... myelofibrosis, hereditary telangiectasia, coagulation defects, polycythemia vera, and aplastic ...
(Date:9/30/2014)... Jiwa Law Corporation, a personal injury law ... now be offering free consultation for personal injury claims of ... firm for the first time to meet the Vancouver ICBC ... opportunity to understand what their rights are. The experts at ... to explain to them what the law firm can do ...
Breaking Medicine News(10 mins):Health News:Disease decoded: Gene mutation may lead to development of new cancer drugs 2Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 2Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 3Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 4Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 2Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 3Health News:Living with a Disability Magazine Marks National Sickle Cell Health Month with New Article on Hematological Disorders 2Health News:Living with a Disability Magazine Marks National Sickle Cell Health Month with New Article on Hematological Disorders 3Health News:Jiwa Law Corporation Now Offers Personal Injury Consultation Without Any Charge 2
... be used for artificial blood vessels in the future as ... synthetic materials currently used for bypass operations, reveals a thesis ... Produced by a bacterium known as Acetobacter xylinum ... pressure and works well with the body,s own tissue. The ...
... cold knows, food tastes wrong when the nose is clogged, ... of taste operates normally only when the olfactory system is ... influences olfactory perception, however, has been vanishingly rareuntil now. In ... Brandeis researchers report just such an influence. Neuroscientist ...
... , ... America,s audio therapy partner enlisting the public to send free treatment e-cards to the ... ... Sound Solutions for a Healthier Life, today launched an online holiday program advancing the ...
... against inherited form of disease , TUESDAY, Dec. 22 (HealthDay ... gene therapy may offer lifetime protection against the progression of ... study in mice. , The most common form of emphysema ... mutation in the alpha-1 anti-trypsin gene, the authors of the ...
... Senate bill, which could be approved by Christmas, but others ... health-care experts are throwing their support behind the Senate version ... will be passed before Christmas since Senate Democrats have garnered ... , "Overall, it is a multi-dimensional attack on the ...
... ... unprecedented opportunities on the horizon, and more scientists than ever working ... the National Multiple Sclerosis Society continues to propel research forward to ... to support 345 new and ongoing projects in its research portfolio, ...
Cached Medicine News:Health News:Got taste? 2Health News:Prescription Audio Gives the Gift of Stress Relief This Holiday Season 2Health News:Prescription Audio Gives the Gift of Stress Relief This Holiday Season 3Health News:Gene Therapy Holds Promise for Emphysema 2Health News:Health Reform Package Continues to Advance 2Health News:Health Reform Package Continues to Advance 3Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 2Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 3Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 4Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 5Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 6Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 7Health News:National MS Society Continues to Propel Research Forward to End MS - Launches 2010 With Call for Research Grants to Pursue CCSVI Leads 8
(Date:9/30/2014)... , Sept. 30, 2014 One week after World ... milestone: Alzheimer,s Team reaches over 200,000 supporters. ... caregivers, was developed to draw attention to clinical trials, ... It also provides inspirational support and fosters online engagement ... the leading healthcare concern for people over the age ...
(Date:9/30/2014)... , Sept. 30, 2014 Headquartered in ... is a diversified company comprised of several specialized partners ... technology and the proven expertise of its team of ... wellness. WholeHealth Products, line of more than 10 professional ... and its more than 8 retail consumer tests is ...
(Date:9/30/2014)... N.Y. , Sept. 30, 2014  Millennium ... Millennium Medical Devices, has executed a sales, marketing ... Florida based provider of ... Accountable Care Organizations (ACOs) and hospitals through a ... serves over 10,400 active Physician Purchasing Accounts that ...
Breaking Medicine Technology:MediciGlobal's Alzheimer's Community Reaches 200,000 likes and more than half a million weekly visitors 2MediciGlobal's Alzheimer's Community Reaches 200,000 likes and more than half a million weekly visitors 3MediciGlobal's Alzheimer's Community Reaches 200,000 likes and more than half a million weekly visitors 4WholeHealth Products Announces The Discovery Of The "Autism And Fragile X" Microwell And Rapid Diagnostic Test 2Millennium Healthcare Secures New Sales, Marketing and Distribution Agreement 2Millennium Healthcare Secures New Sales, Marketing and Distribution Agreement 3
... Arizona Alliance for Chronic Care (AACC) , an assembly ... complex medical conditions such as cancer, multiple sclerosis, hemophilia, ... a small win with the advancement of SB 1401. ... SB 1401 protects patients from new, unfair out-of-pocket costs ...
... the leader in heart rate monitoring and fitness assessment technologies, ... Technology Supplier" for U.S. Soccer through 2013.  ... national and international events, including the London 2012 Olympic and ... used to help these nine National Teams gain a competitive ...
Cached Medicine Technology:Legislation to Keep Life-saving Drugs Affordable Advances to the Senate Floor 2Legislation to Keep Life-saving Drugs Affordable Advances to the Senate Floor 3Polar Named Official Heart Rate Technology Supplier of U.S. Soccer Federation 2Polar Named Official Heart Rate Technology Supplier of U.S. Soccer Federation 3
... In addition to three conventional measurement modes ... also incorporates a new axial length measuring ... by calculating sonic velocity for conversion at ... length by calculating each tissues sonic velocity ...
... first very high frequency digital ultrasound eye ... provides microscopic resolution images and precision measurement ... of the human eye. Artemis is a ... In use, the patient leans forward placing ...
... 1000 is the most advanced ophthalmic ultrasound ... operates with a single Macintosh desktop or ... a streamlined internal probe rotator. Every aspect ... The UltraFast 12 MHz B-probe operates on ...
... a combination A-scan and B-scan system, providing ... incorporates a high frequency, low noise probe ... capture immediately upon application of the probe ... the axial length of both eyes differ ...
Medicine Products: