Navigation Links
Towards more effective treatment for multiple myeloma
Date:1/9/2012

ells from patients. When used in animal studies with the proteasome inhibitor bortezomib, MAL3-101 significantly boosted its anti-myeloma effects. Dr. Batuman's team found that by targeting Hsp70 activity, the dosage of synergic agents such as bortezomib could be reduced without compromising their effectiveness. The ability to reduce dosage makes it possible to continue the use of drugs that are toxic at higher concentrations. The addition of new synergistic agents also enriches the treatment arsenal by reducing drug resistance.

"The results of our study are very encouraging," says Dr. Batuman. "While this is not a cure and it will be some time before the compound is developed as a drug, we believe that MAL3-101, when used synergistically with existing therapies, could reduce overall drug concentrations and avoid treatment resistance."

Dr. Batuman adds, "It is possible to speculate that MAL3-101 may also modulate development of the multiple myeloma cancer stem cell. The relapse of multiple myeloma in patients in whom complete remission had been achieved is currently thought to indicate the presence of treatment-resistant multiple myeloma cancer stem cells. At Downstate, a group effort is now geared towards identifying and targeting these cancer stem cells in multiple myeloma. The anti-myeloma effects of MAL3-101 could include inhibition of cancer stem cell development, since the Hsp-70 function is required in early plasma cell development. Our prediction is that antagonism of the Hsp-70 chaperone or chaperones by affecting non-redundant pathways could be effective in multiple myeloma treatment."


'/>"/>
Contact: Ron Najman
ron.najman@downstate.edu
718-270-2696
SUNY Downstate Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Chocolate Industry Leaders Sign Agreement, Align on Path Towards Increasing Consumer Availability & Consistency of Beneficial Cocoa Flavanols
2. Fitness Trend Towards Online Personal Training Gets Real-World Weight Loss Results on FitOrbit.com
3. Electronic Health Information Leader Says Physician Practice Redesign is Vital Next Step Towards Safer, More Effective Care Delivery
4. Miles for Hope’s Moving Towards A Cure(SM) Brain Tumor Walk in Boston Raising Funds for Brain Tumor Vaccine and Massachusetts General Hospital
5. PaperFree Florida to help move physicians towards electronic health records
6. Study shows behaviors and attitudes towards oral sex are changing
7. Warning about benevolent sexism and mens apparently positive attitudes towards women
8. Top scientists unite to develop global scientific strategy Towards An HIV Cure
9. Steps towards the use of adult stem cells for gene therapy
10. Steps being taken towards achieving an early diagnosis of cancer of the large intestine
11. Transending Borders Towards Global Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... INTEGRATED Healthcare Strategies, a trusted compensation ... its 2015 Children’s Hospitals Executive Compensation Survey. This ... and the survey results are exclusive to participants. ... on 60 executive and director level positions, and ... subsidiary children’s hospitals. Additionally, it provided a separate ...
(Date:3/5/2015)... Leading nutritional supplement provider Metabolic Nutrition ... Arnold Fitness EXPO in Columbus, Ohio which ... display booth featuring free samples of its superior products ... fat burner Synedrex. The company will also be giving ... top-of-the-line supplements and miniature action figures of its iconic ...
(Date:3/5/2015)... 2015 Nutrition Leaders, a premier purveyor ... to offer reformulated Millennium 500 Creatine to its customers. ... a German grade creatine supplement that has been micronized ... and aid with overall strength gains in users. , ... a reserve energy source in the body and helps ...
(Date:3/5/2015)... Jordan, Utah (PRWEB) March 05, 2015 ... defibrillator by LifeVest® as a treatment option for sudden ... continuously monitors heart rhythm and can detect any life-threatening ... device will alert the patient before delivering a treatment ... , Dr. Adam Elhaddi of Jordan Valley Medical Center ...
(Date:3/5/2015)... 2015 Kevin Batsford lost his brother ... of drug addiction. The siblings frequented bridges, highways, and ... to seek refuge during the night. Batsford said that ... for his outward appearance, hygiene, or overall well being- ... Central reported on Feb. 23rd that Batsford left ...
Breaking Medicine News(10 mins):Health News:Participation Is Now Open For INTEGRATED Healthcare Strategies 2015 Children’s Hospitals Executive Compensation Survey 2Health News:Metabolic Nutrition Exhibiting at 2015 Arnold Sports Festival and Fitness EXPO This Week 2Health News:Nutrition Leaders Offers Reformulated Millennium 500 German Grade Creatine 2Health News:New Technology Behind LifeVest® Wearable Defibrillator Saves the Life of Utah Man in Cardiac Arrest 2Health News:New Technology Behind LifeVest® Wearable Defibrillator Saves the Life of Utah Man in Cardiac Arrest 3Health News:The Homeless’ Unaddressed Drug Addiction Continues to Spiral Out of Control, Harbor Village Detox Stresses Treatment for the Homeless 2Health News:The Homeless’ Unaddressed Drug Addiction Continues to Spiral Out of Control, Harbor Village Detox Stresses Treatment for the Homeless 3
... ... New Jersey Anti-Poverty Charity, Seeks Buyers for 35mm Michael Jackson Film Print of "Thriller" ... ... New Jersey anti-poverty charity, seeks serious inquiries only for historic 35mm film print of ...
... ... pressure, adrenal fatigue, and how to best deal with these health issues. , ... San Diego, CA (PRWEB) July 3, 2009 ... of common health issues such as high blood pressure. High blood pressure is caused by ...
... ... infusion, specialty medication, respiratory and DME services, is expanding. Two new pharmacies in Rochester, ... a new product line for Upstate HomeCare. , ... Clinton, NY (PRWEB) June 22, 2009 -- Upstate ...
... Support Principles to Govern Health Insurer Behavior , , ... voters (88%) believe that health insurance companies have too much ... out of five (80%) voters support the concept of a ... of guiding principles for health insurance companies with respect to ...
... forces won an important battle yesterday when the Ohio Supreme ... centers must properly follow FDA guidelines in administering RU-486 (also ... health of women using the drug. , , ... a challenge by Planned Parenthood to a 2004 law requiring ...
... of the incidence of breast cancer in Italy per 100,000 ... to 2005 shows a 72 percent spike above official estimates ... of +28.6 percent found in the youngest group studied (ages ... rely on hospitalization databases that track major breast surgeries rather ...
Cached Medicine News:Health News:A New Jersey Charity Seeks Serious Inquiries for Historic 35mm Film Print of Michael Jackson's "Thriller" Music Video 2Health News:A New Jersey Charity Seeks Serious Inquiries for Historic 35mm Film Print of Michael Jackson's "Thriller" Music Video 3Health News:A New Jersey Charity Seeks Serious Inquiries for Historic 35mm Film Print of Michael Jackson's "Thriller" Music Video 4Health News:A New Jersey Charity Seeks Serious Inquiries for Historic 35mm Film Print of Michael Jackson's "Thriller" Music Video 5Health News:Upstate HomeCare Expands, Adds Pharmacies 2Health News:Upstate HomeCare Expands, Adds Pharmacies 3Health News:4 out of 5 CA Voters Demand Health Insurer "Code of Conduct" 2Health News:4 out of 5 CA Voters Demand Health Insurer "Code of Conduct" 3Health News:4 out of 5 CA Voters Demand Health Insurer "Code of Conduct" 4Health News:4 out of 5 CA Voters Demand Health Insurer "Code of Conduct" 5Health News:4 out of 5 CA Voters Demand Health Insurer "Code of Conduct" 6Health News:Ohio Supreme Court Strikes a Blow to Planned Parenthood in Upholding Regulation of 'Abortion Pill' 2Health News:Rate of Breast Cancer in Italy Significantly Higher Than Previously Reported 2Health News:Rate of Breast Cancer in Italy Significantly Higher Than Previously Reported 3
(Date:3/5/2015)... , Mar. 05, 2015 Research and Markets ... the "Japan Pharma Outlook 2015: Year to Watch ... Initiatives" report to their offering. ... from April -2014 (Annexure 1) is a ... - whether generic or innovator. The most of the ...
(Date:3/5/2015)... March 5, 2015 Hitachi ... generation of OASIS *    at ECR 2015 ... power will set a benchmark for patient-centric care. The ... prevent delays whilst optimizing workflow management and costs. OASIS ... and safety for imaging in Neurology, Orthopaedics, Paediatrics, Oncology, ...
(Date:3/5/2015)... Mr Minoru Yoshizumi , ... Japan , is pleased to announce the release ... System at the European Radiology Congress (ECR). Delegates will ... the Hitachi Medical Systems booth 323, Expo C. ...      (Photo: http://photos.prnewswire.com/prnh/20150305/732754-b ) , , ...
Breaking Medicine Technology:Japan Pharma Outlook 2015: Year to Watch out for Authorized Generics (AGs), Biosimilars and Overseas Strategic Initiatives 2Japan Pharma Outlook 2015: Year to Watch out for Authorized Generics (AGs), Biosimilars and Overseas Strategic Initiatives 3Hitachi Medical Systems Europe Launches the New Generation of OASIS*- The World's Most Powerful Open High-Field 1.2T MRI - A New Level in Patient-Centric Care 2Hitachi Medical Systems Europe Launches the New Generation of OASIS*- The World's Most Powerful Open High-Field 1.2T MRI - A New Level in Patient-Centric Care 3Hitachi Aloka Medical, Ltd. Introduces EggQus AOS 100E - a Compact and Lightweight Ultrasound Bone Densitometry System 2Hitachi Aloka Medical, Ltd. Introduces EggQus AOS 100E - a Compact and Lightweight Ultrasound Bone Densitometry System 3
... the second consecutive year, Orthocare Innovations has been selected by R&D ... this award for its Galileo™ system, a novel approach for measuring, analyzing ... injury or disease. , , ...   http://photos.prnewswire.com/prnh/20100712/DA33752LOGO ) , , ...
... July 12 Mylan Inc. (Nasdaq: MYL ) announced today that ... 29, 2010 , at 10 a.m. ET , to review the company,s ... . Mylan will release its financial results on July 29 before ... The dial-in number ...
Cached Medicine Technology:Orthocare Innovations Receives Prestigious R&D 100 Award for Novel Web-Based Rehabilitation Outcomes Assessment System 2Mylan Schedules Second Quarter 2010 Financial Results Conference Call and Live Webcast 2
Multiwindow transcranial and peripheral Doppler system....
... Multi frequency and ... emboli detection and fitted ... and tests for hemodynamic ... suitable as well for ...
One channel transcranial Doppler...
... an advanced Doppler system that allows non-invasive ... body. This method of measurement is particularly ... blood to the brain. , ,TCD is ... problems such as vasospasm and intracranial stenosis. ...
Medicine Products: