Navigation Links
Toward medicines that recruit the body's natural disease-fighting proteins
Date:8/22/2012

PHILADELPHIA, Aug. 22, 2012 Like recruiters pitching military service to a throng of people, scientists are developing drugs to recruit disease-fighting proteins present naturally in everyone's blood in medicine's war on infections, cancer and a range of other diseases. They reported on the latest advances in this new approach here today at the 244th National Meeting & Exposition of the American Chemical Society, the world's largest scientific society.

David Spiegel, M.D., Ph.D., who heads one of the major research teams developing "antibody-recruiting molecules" (or ARMs), said that the approach is a response to the old and seemingly impossible dream of identifying "magic bullets" for wide-ranging diseases. Antibodies are components of the immune defense system that latch onto microbes and other foreign material in the body and mark them for destruction.

"Antibodies have been wonderful drugs for autoimmune diseases and cancer," Spiegel explained. "But, like other protein-based drugs, they cannot be given in a pill, and must be injected. They can also cause life-threatening allergic or immune reactions. We are developing a work-around ― antibody-recruiting medicines that can be taken orally and induce a patient's own antibodies to fight disease. They would be less expensive and easier to make. We hope it's the starting point toward entirely new approaches for treating a wide range of diseases."

Everyone has numerous antibodies circulating in the blood, each programmed by the immune system to latch onto and mark for destruction specific bacteria, viruses, allergens (like plant pollen) and other material ― termed antigens ― that the body recognizes as foreign. The body makes these antibodies as people are exposed to microbes and allergens in the environment.

However, researchers don't know why people have antibodies against some structures, like the 2,4-dinitrophenyl (DNP) epitope, which is similar to ingredients found in certain pesticides and agricultural chemicals. It could be due to environmental exposures, but researchers also think the body could have made these antibodies when exposed to some other substance that resembles DNP.

Antibodies against DNP are what Spiegel's team at Yale University is using in one strategy to make the immune system target various cancers and HIV, the virus that causes AIDS.

Most of the medications in use today, from aspirin to cancer chemotherapy drugs, fall into that small-molecule category, just like ARMs.

"These ARMs don't kill HIV directly," Spiegel explained. "Instead, they just trick the body into targeting HIV for destruction by its normal immune mechanisms."

ARMs for cancer work well in laboratory mice, which are stand-ins for humans in these types of experiments, and such tests for anti-HIV ARMs are currently ongoing. Spiegel said that ARMs could also be designed to treat other conditions, such as autoimmune diseases like rheumatoid arthritis.

The team is using another approach against Staph infections. It involves tricking bacteria into the equivalent of painting a "bull's eye" on themselves, in effect inviting attack by the immune system. It represents the first time that scientists have been able to actually put small molecules into the surface of Staphylococcus aureus, which is becoming more and more resistant to traditional antibiotics. Spiegel said that this method also might work on other types of bacteria, such as Streptococcus microbes that cause pneumonia and strep throat.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
215-418-2056 (Philadelphia Press Center, Aug. 17-23)
202-872-6042

Michael Woods
m_woods@acs.org
215-418-2056 (Philadelphia Press Center, Aug. 17-23)
202-872-6293
American Chemical Society


Source:Eurekalert

Related medicine news :

1. Toward new drugs for the human and non-human cells in people
2. Drive toward a viable City of the Future
3. New report describes 7 essential steps toward an AIDS-free generation
4. Working toward an AIDS-free generation
5. A further step towards preventing diabetes
6. BioMed Central presents Challenges in Malaria Research: Progress Towards Elimination
7. Attitudes toward outdoor smoking ban at moffitt Cancer Center evaluated
8. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
9. DNA Testing Finds Allergens, Toxins in Traditional Chinese Medicines
10. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
11. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica ... Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs ... Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. ... his M.D from the David Geffen School of Medicine at UCLA. He trained in ... to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
Breaking Medicine Technology: