Navigation Links
Toward medicines that recruit the body's natural disease-fighting proteins
Date:8/22/2012

PHILADELPHIA, Aug. 22, 2012 Like recruiters pitching military service to a throng of people, scientists are developing drugs to recruit disease-fighting proteins present naturally in everyone's blood in medicine's war on infections, cancer and a range of other diseases. They reported on the latest advances in this new approach here today at the 244th National Meeting & Exposition of the American Chemical Society, the world's largest scientific society.

David Spiegel, M.D., Ph.D., who heads one of the major research teams developing "antibody-recruiting molecules" (or ARMs), said that the approach is a response to the old and seemingly impossible dream of identifying "magic bullets" for wide-ranging diseases. Antibodies are components of the immune defense system that latch onto microbes and other foreign material in the body and mark them for destruction.

"Antibodies have been wonderful drugs for autoimmune diseases and cancer," Spiegel explained. "But, like other protein-based drugs, they cannot be given in a pill, and must be injected. They can also cause life-threatening allergic or immune reactions. We are developing a work-around ― antibody-recruiting medicines that can be taken orally and induce a patient's own antibodies to fight disease. They would be less expensive and easier to make. We hope it's the starting point toward entirely new approaches for treating a wide range of diseases."

Everyone has numerous antibodies circulating in the blood, each programmed by the immune system to latch onto and mark for destruction specific bacteria, viruses, allergens (like plant pollen) and other material ― termed antigens ― that the body recognizes as foreign. The body makes these antibodies as people are exposed to microbes and allergens in the environment.

However, researchers don't know why people have antibodies against some structures, like the 2,4-dinitrophenyl (DNP) epitope, which is similar to ingredients found in certain pesticides and agricultural chemicals. It could be due to environmental exposures, but researchers also think the body could have made these antibodies when exposed to some other substance that resembles DNP.

Antibodies against DNP are what Spiegel's team at Yale University is using in one strategy to make the immune system target various cancers and HIV, the virus that causes AIDS.

Most of the medications in use today, from aspirin to cancer chemotherapy drugs, fall into that small-molecule category, just like ARMs.

"These ARMs don't kill HIV directly," Spiegel explained. "Instead, they just trick the body into targeting HIV for destruction by its normal immune mechanisms."

ARMs for cancer work well in laboratory mice, which are stand-ins for humans in these types of experiments, and such tests for anti-HIV ARMs are currently ongoing. Spiegel said that ARMs could also be designed to treat other conditions, such as autoimmune diseases like rheumatoid arthritis.

The team is using another approach against Staph infections. It involves tricking bacteria into the equivalent of painting a "bull's eye" on themselves, in effect inviting attack by the immune system. It represents the first time that scientists have been able to actually put small molecules into the surface of Staphylococcus aureus, which is becoming more and more resistant to traditional antibiotics. Spiegel said that this method also might work on other types of bacteria, such as Streptococcus microbes that cause pneumonia and strep throat.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
215-418-2056 (Philadelphia Press Center, Aug. 17-23)
202-872-6042

Michael Woods
m_woods@acs.org
215-418-2056 (Philadelphia Press Center, Aug. 17-23)
202-872-6293
American Chemical Society


Source:Eurekalert

Related medicine news :

1. Toward new drugs for the human and non-human cells in people
2. Drive toward a viable City of the Future
3. New report describes 7 essential steps toward an AIDS-free generation
4. Working toward an AIDS-free generation
5. A further step towards preventing diabetes
6. BioMed Central presents Challenges in Malaria Research: Progress Towards Elimination
7. Attitudes toward outdoor smoking ban at moffitt Cancer Center evaluated
8. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
9. DNA Testing Finds Allergens, Toxins in Traditional Chinese Medicines
10. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
11. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... 2016 , ... More than a third of American adults are considered obese, ... has received increased attention in recent years, as an article published May ... loss, most people are familiar with the basic requirements of maintaining a healthy diet ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... W.S. ... products, announced today that it has been recognized as one of the best small ... Badger was named as one of nine small businesses providing progressive benefits to new ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... This ... of a stroke, which we as a society can control and change. , As ... occurs nearly every 40 seconds within the United States. Plus, with an estimated 129,000 ...
(Date:5/27/2016)... ... ... Beleza Medspa has initiated a new program to assist active ... time that Coolsculpting is being used for for more than just cosmetic purposes. ... the prescribed body-fat standard, measured by the circumference-based tape method. The tape-test is ...
(Date:5/27/2016)... Wis. (PRWEB) , ... May 27, 2016 , ... ... $90,000 in scholarships to students studying complementary medicine. Allison Outerbridge is this year’s ... accepted her award on May 18 at the university’s Student Leadership Awards ceremony. ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... 2016"market research report that provides an overview on ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
(Date:5/24/2016)... May 24, 2016 Cirujanos holandeses ... ayudar a los médicos a compartir sus mejores prácticas ... escala mundial. Profesionales médicos de Europa, África, ... apuntado a la aplicación, que combina la transmisión en ... totalmente seguro. Educación   "Imagine un ...
(Date:5/24/2016)... May 24, 2016   , ... non-inferiority in overall bowel cleansing and superiority in ... leansing of the ... ) , Norgine B.V. today announced new positive data ... and ascorbate bowel preparation) versus standard 2 litre PEG with ascorbate. ...
Breaking Medicine Technology: