Navigation Links
Toward fixing damaged hearts through tissue engineering
Date:1/22/2014

In the U.S., someone suffers a heart attack every 34 seconds their heart is starved of oxygen and suffers irreparable damage. Engineering new heart tissue in the laboratory that could eventually be implanted into patients could help, and scientists are reporting a promising approach tested with rat cells. They published their results on growing cardiac muscle using a scaffold containing carbon nanofibers in the ACS journal Biomacromolecules.

Gordana Vunjak-Novakovic, Rui L. Reis, Ana Martins and colleagues point out that when damaged, adult heart tissue can't heal itself very well. The only way to fix an injured heart is with a transplant. But within the past decade, interest in regenerating just the lost tissue has surged. The trick is to find materials that, among other things, are nontoxic, won't get attacked by the body's immune system and allow for muscle cells to pass the electrical signals necessary for the heart to beat. Previous research has found that chitosan, which is obtained from shrimp and other crustacean shells, nearly fits the bill. In lab tests, scientists have used it as a scaffold for growing heart cells. But it doesn't transmit electrical signals well. Vunjak-Novakovic's team decided to build on the chitosan development and coax it to function more like a real heart.

To the chitosan, they added carbon nanofibers, which can conduct electricity, and grew neonatal rat heart cells on the resulting scaffold. After two weeks, cells had filled all the pores and showed far better metabolic and electrical activity than with a chitosan scaffold alone. The cells on the chitosan/carbon scaffold also expressed cardiac genes at higher levels.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related medicine news :

1. A Priceless Resolution: Take That First Step Toward Financial Security
2. Athletes “Toward Injury Prevention in Sports” TIPS Gets Going in Las Vegas
3. Toward lowering titaniums cost and environment
4. Diet Doc Hormone Diets & Weight Loss Plans Launches Monthly Diet Newsletter Geared Toward Keeping Patients Informed with Interesting Health News, Diet Tips & Recipe Ideas
5. Considerable gender, racial and sexuality differences in attitudes toward bisexuality
6. Shifting Toward Preventative Healthcare Models in the United States
7. PharmaFocus: HIV - R&D Strategies towards Cure and Prevention
8. Federal Grant of $275,000 Funds Study of Young Adult Attitudes Toward Flavored Tobacco
9. Federal grant of $275,000 funds study of young adult attitudes toward flavored tobacco
10. New Obamacare Standards and the Lure of Federally Compliant Wellness Incentives are Guiding Business Owners Towards Orriant
11. Current Progress Towards ANDA Approval of Hydroxyprogesterone Caproate Injection, USP
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... September 19, 2017 , ... Trusted debt-reduction firm CreditAssociates, LLC has announced two ... in excess of $835 million in resolved debt for its clients. , Credit card ... of the categories of debt settled by the company. With more than a decade ...
(Date:9/19/2017)... ... September 19, 2017 , ... Arizona-based ... as the President of its HealthBI division. McFarland will grow the organization’s ... , “Scott is a utility player who balances his day as a ...
(Date:9/19/2017)... Hill, CT (PRWEB) , ... September 19, 2017 ... ... support, today announced the winners of the Entrepreneur Innovation Awards (EIA), held this ... all of whom are Connecticut-based companies and entrepreneurs, presented their innovative project ideas ...
(Date:9/19/2017)... ... September 19, 2017 , ... MelaKids, a Laredo-based company, has introduced a new ... we’re born, Nature gives us a full supply of melanin – in the back ... this natural glare-reducing pigment; however, around the age of thirty, we develop a yellow-brown ...
(Date:9/19/2017)... ... September 19, 2017 , ... Presenting its annual ... (SPBA) hosted “Expanding Your Success” with an educational emphasis. , The three-day ... best practices for third party administrators (TPAs) related to health plan management and ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... , Sept. 5, 2017 Oramed Pharmaceuticals Inc. ... ), a clinical-stage pharmaceutical company focused on the development ... has successfully concluded its meeting with the U.S. Food ... oral insulin formulation. ... the regulatory pathway for submission of ORMD-0801, would be ...
(Date:9/1/2017)...  Bayer will present the latest research from across its ... (ESMO) 2017 Congress, September 8-12 in Madrid, Spain ... clinical data on Bayer,s marketed portfolio and late-stage compounds as ... "We value the opportunity to ... at ESMO," said Carsten Brunn , Head of Pharmaceuticals, ...
(Date:8/29/2017)... 29, 2017 In a move that promises ... compliance for veterinary practices of all sizes, Cubex LLC ... that makes TITAN,s expertise in physical security, drug diversion ... clients nationally. ... controlled substances is at risk today," said TITAN founder ...
Breaking Medicine Technology: